4-Nonylphenylboronic acid
- Product Name
- 4-Nonylphenylboronic acid
- CAS No.
- 256383-45-6
- Chemical Name
- 4-Nonylphenylboronic acid
- Synonyms
- AKOS BRN-0129;FAAH/MAGL-IN-4;Nonylbenzeneboronic acid;(4-nonylphenyl)boronicaci;4-Nonylphenylboronic acid;4-N-nonylphenylbronic acid;4-N-NONYLPHENYLBORONIC ACID;1-Borono-4-(non-1-yl)benzene;4-N-NONYLBENZENEBORONIC ACID;4-(Non-1-yl)benzeneboronic acid
- CBNumber
- CB3346668
- Molecular Formula
- C15H25BO2
- Formula Weight
- 248.17
- MOL File
- 256383-45-6.mol
4-Nonylphenylboronic acid Property
- Melting point:
- 82-85°C
- Boiling point:
- 385.3±35.0 °C(Predicted)
- Density
- 0.97±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 30 mg/ml)
- pka
- 8.72±0.16(Predicted)
- form
- solid
- color
- White
- Water Solubility
- Insoluble in water.
- BRN
- 8215118
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- CAS DataBase Reference
- 256383-45-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 13140
- Product name
- 4-(n-nonyl) Benzeneboronic Acid
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $19
- Updated
- 2024/03/01
- Product number
- 13140
- Product name
- 4-(n-nonyl) Benzeneboronic Acid
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $111
- Updated
- 2024/03/01
- Product number
- 13140
- Product name
- 4-(n-nonyl) Benzeneboronic Acid
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $39
- Updated
- 2024/03/01
- Product number
- 13140
- Product name
- 4-(n-nonyl) Benzeneboronic Acid
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- B185293
- Product name
- 4-(N-Nonyl)BenzeneboronicAcid
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
4-Nonylphenylboronic acid Chemical Properties,Usage,Production
Description
Nonylbenzeneboronic acid (CAS 256383-45-6) is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH, the enzyme which hydrolyzes and deactivates anandamide), IC50=9.1 nM1. Also inhibits monoacylglycerol lipase (MAGL, the enzyme which hydrolyzes 2-arachidonoyl-glycerol), IC50=7.9 μM.1
Uses
4-n-Nonylbenzeneboronic acid is a potent inhibitor of fatty acid amide hydrolase. It is also able to inhibit monoacylglycerol lipase (MAGL), which hydrolyzes 2-arachidonoyl glycerol (2-AG).
in vitro
4-(n-nonyl) benzeneboronic acid was synthezed as a potent inhibitor of faah, with an ic50 of 9.1 nm. 4-(n-nonyl) benzeneboronic acid was also found to be able to inhibit magl, which could hydrolyze 2-arachidonoyl glycerol, but at around 1000-fold higher concentration. moreover, it was found that as the most potent para-substituted compound, 4-(n-nonyl) benzeneboronic acid showed rather high pka of 9.1. in addition, the molecular docking was utilized to gain insight on the faah binding mode of 4-(n-nonyl) benzeneboronic acid and a putative binding mode was observed [1].
IC 50
9.1 nm
References
[1] ANNA MINKKILÄ*. Discovery of Boronic Acids as Novel and Potent Inhibitors of Fatty Acid Amide Hydrolase[J]. Journal of Medicinal Chemistry, 2008, 51 22: 7057-7060. DOI:10.1021/jm801051t
4-Nonylphenylboronic acid Preparation Products And Raw materials
Raw materials
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