2-Chloroethylamine hydrochloride Property

Melting point:

140-150 °C(lit.)

storage temp. 

Store below +30°C.

solubility 

5666g/l

form 

Crystalline Powder

color 

White to light beige

PH

2-3 (5666g/l, H2O, 20℃)

Water Solubility 

SOLUBLE

Sensitive 

Hygroscopic

BRN 

3590304

InChI

InChI=1S/C2H6ClN.ClH/c3-1-2-4;/h1-2,4H2;1H

InChIKey

ONRREFWJTRBDRA-UHFFFAOYSA-N

SMILES

NCCCl.[H]Cl

CAS DataBase Reference

870-24-6(CAS DataBase Reference)

EPA Substance Registry System

2-Chloroethylamine hydrochloride (870-24-6)

Safety

Hazard Codes 

Xi,C

Risk Statements 

36/37/38-68-34

Safety Statements 

26-36-37/39-45-36/37/39

RIDADR 

UN3261

WGK Germany 

3

RTECS 

KR1800000

F 

3-10-34

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29211980

Toxicity

LD50 orally in Rabbit: > 2000 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

H341Suspected of causing genetic defects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-Chloroethylamine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

2-Chloroethylamine hydrochloride (C2H7Cl2N, CAS registry No. 870-24-6) is a white to light beige crystalline powder. It is soluble in water and stable at room temperature in closed containers under normal storage and handling conditions. It should store in a tightly closed container, in a cool, dry, well-ventilated area away from incompatible substances and should be protected from moisture.

Application

2-Chloroethylamine hydrochloride is an important fine chemical intermediate. It can be used for the synthesis of fluvoxamine maleate, which is an important antidepressant drug. 2-Chloroethylamine hydrochloride can also be used as the substrate to synthesize 2-(2'-Aminoaryl)oxazolines and their derivatives, which have been studied as ligands for a variety of metal chelates and are known to possess biological activity in both free ligand and chelated forms. Meanwhile, 2-chloroethylamine hydrochloride can be used for chemical modification of chitosan to improve the biological activity of chitosan.
2-Chloroethylamine hydrochloride can also react with hydroxypropyl starch (HPS) to form aminoethyl hydroxypropyl starch (AEHPS), which can react with collagen peptide (COP) by using microbial transglutaminase (MTGase) as biocatalyst to synthesize aminoethyl hydroxypropyl starch collagen peptide (AEHPS-COP). The AEHPS-COP showed a promising potential application in cosmetic, biomedical and pharmaceutical fields with improved in vitro antioxidant activities.

Chemical Properties

WHITE TO LIGHT BEIGE CRYSTALLINE POWDER

Uses

2-chloroethylamine hydrochloride is used as an intermediate in active pharmaceutical ingredients and dyes. It is also used in organic synthesis. Further, it is employed as a derivatizing reagent for amino acids, dipeptides and nucleotides.

Uses

2-Chloroethylamine hydrochloride can be used in the preparation of novel Schiff base ligands. These ligands, when immobilized on silica gels, form inexpensive materials for the removal of metal ions such as Ni²⁺ and Co²⁺ ions from contaminated water.
Other applications:

• Alginate derivatization via aminoethylation to form aminoethyl alginate.
• Synthesis of N-(2-chloroethyl)-benzaldimine.
• Derivatization of starch to form aminoethyl (AE-St) starch derivatives.