1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE
- Product Name
- 1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE
- CAS No.
- 5279-32-3
- Chemical Name
- 1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE
- Synonyms
- 5,6-Dibromobenzo[d][1,3]dioxole;5,6-DIBROMO-1,3-BENZODIOXOLE;5,6-DIBROMO-BENZO(1,3)DIOXOLE;1,3-Benzodioxole, 5,6-dibromo-;3-(trifluoromethyl)sulphanylaniline;4,5-Methylenedioxy-1,2-dibromobenzene;4,5-Dibromo-1,2-methylenedioxybenzene;1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE;5,6-Dibromo-1,3-benzodioxole~4,5-Methylenedioxy-1,2-dibromobenzene
- CBNumber
- CB3351828
- Molecular Formula
- C7H4Br2O2
- Formula Weight
- 279.91
- MOL File
- 5279-32-3.mol
1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE Property
- Melting point:
- 83-85°C
- Boiling point:
- 294.7±40.0 °C(Predicted)
- Density
- 2.104±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 10 mg/ml
- form
- A crystalline solid
- color
- Off-white to light brown
- BRN
- 145633
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- S53598
- Product name
- 5,6-DIBROMO-BENZO(1,3)DIOXOLE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
- Product number
- S53598
- Product name
- 5,6-DIBROMO-BENZO(1,3)DIOXOLE
- Purity
- Aldrich
- Packaging
- 100mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- D4737
- Product name
- 5,6-Dibromo-1,3-benzodioxole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- D4737
- Product name
- 5,6-Dibromo-1,3-benzodioxole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $113
- Updated
- 2025/07/31
- Product number
- 26357
- Product name
- 1,2-Dibromo-4,5-methylenedioxybenzene
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE Chemical Properties,Usage,Production
Uses
1,2-Dibromo-4,5-methylenedioxybenzene is an impurity in the synthesis of amphetamines[1].
Synthesis
75-09-2
2563-26-0
5279-32-3
Dichloromethane (762 μL, 11.94 mmol) was added dropwise to a stirred solution of 4,5-dibromobenzene-1,2-diol (2.00 g, 7.46 mmol) and cesium carbonate (3.89 g, 11.94 mmol) in N,N-dimethylformamide (DMF, 75 mL), and the reaction was carried out at room temperature. Subsequently, the reaction mixture was heated to 120 °C and maintained for 2 h, after which it was cooled to room temperature. Upon completion of the reaction, the reaction was quenched by the addition of water (150 mL), and the resulting solution was extracted several times with ethyl acetate (EtOAc, 5 × 100 mL). The organic phases were combined, washed sequentially with water (5×150 mL) and saturated brine (2×150 mL), dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to remove the solvent. Finally, the product was purified by silica gel column chromatography eluting with a gradient of petroleum ether (PET)/ethyl ether (Et2O) (100:0 to 95:5) to afford 5,6-dibromobenzo[d][1,3]dioxole (1.54 g, 5.50 mmol, 74% yield) as a white crystalline solid.
References
[1] Heather E, et al. Organic impurity profiling of 3,4-methylenedioxymethamphetamine (MDMA) synthesised from catechol. Forensic Sci Int. 2015 Mar;248:140-7. DOI:10.1016/j.forsciint.2014.12.021
1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE manufacturers
- Product
- 1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE 5279-32-3
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02