ChemicalBook > CAS DataBase List > Acebutolol hydrochloride

Acebutolol hydrochloride

Product Name
Acebutolol hydrochloride
CAS No.
34381-68-5
Chemical Name
Acebutolol hydrochloride
Synonyms
Neptal;Sectra;Acecor;Neptall;Acebutol;Acetanol;IL-17803A;m&b17,803a;ACEBUTOLOL HCL;M and B 17803A
CBNumber
CB3353130
Molecular Formula
C18H29ClN2O4
Formula Weight
372.89
MOL File
34381-68-5.mol
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Acebutolol hydrochloride Property

Melting point:
141-1430C
storage temp. 
2-8°C
solubility 
Freely soluble in water and in ethanol (96 per cent), very slightly soluble in acetone and in methylene chloride.
form 
Solid
color 
White to Pale Yellow
InChIKey
KTUFKADDDORSSI-UHFFFAOYSA-N
CAS DataBase Reference
34381-68-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
RTECS 
ES5235000
HS Code 
2924296000
Hazardous Substances Data
34381-68-5(Hazardous Substances Data)
Toxicity
LD50 orl-rat: 6620 mg/kg OYYAA2 20,883,80
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A3669
Product name
Acebutolol hydrochloride
Purity
analytical standard
Packaging
1g
Price
$35.8
Updated
2024/03/01
Sigma-Aldrich
Product number
A0040000
Product name
Acebutolol hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
a0040000
Price
$223
Updated
2024/03/01
Alfa Aesar
Product number
J63790
Product name
Acebutolol hydrochloride
Packaging
1g
Price
$63.65
Updated
2024/03/01
Alfa Aesar
Product number
J63790
Product name
Acebutolol hydrochloride
Packaging
5g
Price
$102.65
Updated
2024/03/01
Cayman Chemical
Product number
23393
Product name
Acebutolol (hydrochloride)
Purity
≥98%
Packaging
5g
Price
$127
Updated
2024/03/01
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Acebutolol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Originator

Sectral ,May and Baker ,UK ,1975

Uses

Cardioselective ?adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II)

Uses

Cardioselective β-adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

Uses

5-alpha-reductase inhibitor

Definition

ChEBI: The hydrochloride salt of acebutolol, prepared using equimolar amounts of acebutolol and hydrogen chloride.

Manufacturing Process

Crude 5'-butyramido-2'-(2,3-epoxypropoxy)acetophenone (16 g), isopropylamine (20 g) and ethanol (100 ml) were heated together under reflux for 4 hours. The reaction mixture was concentrated under reduced pressure and the residual oil was dissolved in N hydrochloric acid. The acid solution was extracted with ethyl acetate, the ethyl acetate layers being discarded. The acidic solution was brought to pH 11 with 2 N aqueous sodium hydroxide solution and then extracted with chloroform. The dried chloroform extracts were concentrated under reduced pressure to give an oil which was crystallized from a mixture of ethanol and diethyl ether to give 5'-butyramido- 2'-(2-hydroxy-3-isopropylaminopropoxy)acetophenone (3 g), MP 119-123°C.
Crude 5'-butyramido-2'-(2,3-epoxypropoxy)acetophenone used as starting material was prepared as follows: p-butyramidophenol (58 g; prepared according to Fierz-David and Kuster, Helv. Chim. Acta 1939,2282), acetyl chloride (25.4 g) and benzene (500 ml) were heated together under reflux until a solution formed (12 hours). This solution was cooled and treated with water. The benzene layer was separated and the aqueous layer was again extracted with benzene.
The combined benzene extracts were dried and evaporated to dryness under reduced pressure to give p-butyramidophenyl acetate (38 g) as an off-white solid, MP 102-103°C. A mixture of p-butyramidophenyl acetate (38 g), aluminum chloride (80 g) and 1,1,2,2-tetrachloroethane (250 ml) was heated at 140°C for 3 hours. The reaction mixture was cooled and treated with iced water. The tetrachloroethane layer was separated and the aqueous layer was extracted with chloroform. The combined organic layers were extracted with 2 N aqueous sodium hydroxide and the alkaline solution was acidified to pH 5 with concentrated hydrochloric acid. The acidified solution was extracted with chloroform and the chloroform extract was dried and concentrated under reduced pressure to give 5'-butyramido-2'-hydroxyacetophenone (15.6 g), MP 114-117°C. A solution of 5'-butyramido-2'-hydroxyacetophenone (15.6 g) in ethanol (100 ml) was added to an ethanolic solution of sodium ethoxide which was prepared from sodium (1.62 g) and ethanol (100 ml). The resulting solution was evaporated to dryness under reduced pressure and dimethylformamide (100 ml) was added to the solid residue. Approximately 10 ml of dimethylformamide was removed by distillation under reduced pressure. Epichlorohydrin (25 ml) was added and the solution was heated at 100°C for 4 hours. The solution was concentrated under reduced pressure to give a residual oil which was treated with water to give a solid. The solid was dissolved in ethanol and the resulting solution was treated with charcoal, filtered and concentrated under reduced pressure to give crude 5'-butyramido- 2'-(2,3-epoxypropoxy)acetophenone (16 g), MP 110-116°C.
The crude compound may be purified by recrystallization from ethyl acetate, after treatment with decolorizing charcoal, to give pure 5'-butyramido-2'-(2,3- epoxypropoxy)acetophenone, MP 136-138°C.

brand name

Sectral (Dr. Reddy’s).

Therapeutic Function

beta-Adrenergic blocker

Safety Profile

Poison by ingestion, subcutaneous,intravenous, and intraperitoneal routes. An experimentalteratogen. Other experimental reproductive effects. Whenheated to decomposition it emits toxic fumes of NOx andHCl.

Acebutolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Acebutolol hydrochloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Acebutolol hydrochloride 34381-68-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Acebutolol hydrochloride 34381-68-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Career Henan Chemical Co
Product
Acebutolol hydrochloride 34381-68-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-11

34381-68-5, Acebutolol hydrochlorideRelated Search:

N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE 3'-Acetamidoacetophenone Acebutolol hydrochloride 2-Acetyl-4-butyramidophenol Practolol 3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE, 98 Acebutolol CHEMBRDG-BB 5482082 CHEMBRDG-BB 9070438 1-METHYLAMINO-3-PHENOXY-PROPAN-2-OL AKOS BBS-00007965 1-AMINO-3-PHENOXY-PROPAN-2-OL 3-O-TOLYLOXY-PROPYLAMINE Ethanone, 1-(5-amino-2-methoxyphenyl)- (9CI) METHYL-(3-O-TOLYLOXY-PROPYL)-AMINE CHEMBRDG-BB 5623290 N-(4-propoxyphenyl)acetamide 5'-Amino-2'-hydroxyacetophenone Acebutolol Hcl

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