N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
- Product Name
- N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
- CAS No.
- 393121-74-9
- Chemical Name
- N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
- Synonyms
- AA147 (AA 147;AA147 >=98% (HPLC);ATF6-activator-147;ATF6-activator-147 (AA147);ATF6 agonist compound A147;N-(2-Hydroxy-5-methylphenyl)benzenepropanamide;N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide;Benzenepropanamide, N-(2-hydroxy-5-methylphenyl)-;neurodegenerative disorders,SMA,AA147,ATF6,BPAEC,NRF2,AA 147,Inhibitor,AA-147,inhibit,ROS
- CBNumber
- CB33545952
- Molecular Formula
- C16H17NO2
- Formula Weight
- 255.31
- MOL File
- 393121-74-9.mol
N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide Property
- Boiling point:
- 460.8±40.0 °C(Predicted)
- Density
- 1.190±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml); ethanol (>25 mg/mL)
- form
- solid
- pka
- 9.68±0.48(Predicted)
- color
- Beige to pale orange
- Stability:
- Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- CHM0196190
- Product name
- N-(2-HYDROXY-5-METHYLPHENYL)-3-PHENYLPROPANAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.06
- Updated
- 2021/12/16
- Product number
- DC21979
- Product name
- ATF6agonistcompoundA147
- Purity
- >98%
- Packaging
- 1g
- Price
- $1800
- Updated
- 2021/12/16
N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide Chemical Properties,Usage,Production
Description
AA147 (393121-74-9) is a preferential activator of the ER stress sensing protein ATF6.1 It was able to selectively reduce secretion and extracellular aggregation of destabilized amyloidogenic variants of TTR and LC proteins. AA147-dependent ATF6 activation proceeds via metabolic activation to a reactive electrophile that selectively modifies ER proteins including multiple protein disulfide isomerases.2? AA147 suppressed pluripotency and promoted human stem cell differentiation toward a mesodermal lineage via ER expansion.3? It protected the heart against ischemia/reperfusion (I/R) injury in a mouse model of acute myocardial infarction in an ATF6-dependent manner.4 Brain, kidney, and liver tissue was also protected from I/R damage and impaired proteostasis. AA147 reduced infection of multiple strains of dengue and Zika viruses in an ATF6-independent manner.5 Protects against glutamate-induced cell death is a neuronal-derived cell culture model.6 See companion inhibitor 10-3974.
storage
Store at +4°C
References
Plate et al. (2016), Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation; Elife 5 e15550 Paxman et al. (2018), Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum, proteins; Elife 7 e37168 Kroeger et al. (2018), The unfolded protein response regulator ATF6 promotes mesodermal differentiation; Sci. Signal. 11 eaan5785 Blackwood et al. (2019), Pharmacological ATF6 activation confers global protection in widespread disease models by reprogramming cellular proteostasis; Nat. Commun. 10 187 Almasy et al. (2021), Small molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections; Proc. Natl. Acad. Sci. USA 118 e2012209118 Rosardo et al. (2021), Metabolically Activated Proteostasis Regulators against Glutamate Toxicity by Activating NRF2; ACS Chem. Biol. 16 2852
N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide Suppliers
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 4418
- Advantage
- 55
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44808
- Advantage
- 58
- Tel
- 15865264761
- 486064515@qq.com
- Country
- China
- ProdList
- 3632
- Advantage
- 58
- Tel
- 18130062233
- 3362556465@qq.com
- Country
- China
- ProdList
- 7999
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62163
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24647
- Advantage
- 58
- Tel
- 025-58851786 17714337195
- sales@tybiochem.com
- Country
- China
- ProdList
- 6813
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48461
- Advantage
- 58
- Tel
- 18122215013
- 780229652@qq.com
- Country
- China
- ProdList
- 1143
- Advantage
- 58
- Tel
- 13915962545
- 2881759498@qq.com
- Country
- China
- ProdList
- 2013
- Advantage
- 58
- Tel
- +8618327326525
- masar@topule.com
- Country
- China
- ProdList
- 8467
- Advantage
- 58