ChemicalBook > CAS DataBase List > GLYCINE ANHYDRIDE

GLYCINE ANHYDRIDE

Product Name
GLYCINE ANHYDRIDE
CAS No.
106-57-0
Chemical Name
GLYCINE ANHYDRIDE
Synonyms
c(Gly-Gly);Oxiracetam-1;Cyclodiglycine;Glycinanhydrid;CYCLO(-GLY-GLY);GLYCINANHYDRIDE;ycine anhydride;Diglycolydiamide;Diketopiperazine;Glycerinanhydrid
CBNumber
CB3356030
Molecular Formula
C4H6N2O2
Formula Weight
114.1
MOL File
106-57-0.mol
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GLYCINE ANHYDRIDE Property

Melting point:
>300 °C (lit.)
Boiling point:
213.59°C (rough estimate)
Density 
1.3565 (rough estimate)
refractive index 
1.4487 (estimate)
storage temp. 
Store below +30°C.
solubility 
142g/l
pka
12.88±0.20(Predicted)
form 
Crystalline Powder
color 
White to slightly yellow
Water Solubility 
Soluble in water (142mg/L).
Merck 
14,7466
BRN 
112112
InChIKey
BXRNXXXXHLBUKK-UHFFFAOYSA-N
CAS DataBase Reference
106-57-0(CAS DataBase Reference)
EPA Substance Registry System
2,5-Piperazinedione (106-57-0)
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Safety

Safety Statements 
24/25
WGK Germany 
3
RTECS 
TL6325250
TSCA 
Yes
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G7251
Product name
Glycine anhydride
Purity
cyclic dipeptide
Packaging
25g
Price
$85.7
Updated
2025/07/31
Sigma-Aldrich
Product number
G7251
Product name
Glycine anhydride
Purity
cyclic dipeptide
Packaging
1kg
Price
$1070
Updated
2025/07/31
Sigma-Aldrich
Product number
8.14160
Product name
2,5-Piperazinedione
Purity
for synthesis
Packaging
25G
Price
$151
Updated
2025/07/31
TCI Chemical
Product number
G0100
Product name
Glycine Anhydride
Purity
>98.0%(N)
Packaging
25g
Price
$94
Updated
2025/07/31
TCI Chemical
Product number
G0100
Product name
Glycine Anhydride
Purity
>98.0%(N)
Packaging
500g
Price
$746
Updated
2025/07/31
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GLYCINE ANHYDRIDE Chemical Properties,Usage,Production

Chemical Properties

white to slightly yellow crystalline powder

Uses

2,5-Piperazinedione, can be used as an intermediate in the preparation of various pharmaceutical and biologically active compounds. It can be used in the synthesis of dipeptide isosteres by cross-metathesis.

Definition

ChEBI: A cyclic peptide that is piperazine in which the hydrogens at positions 2 and 5 are replaced by oxo groups.

Synthesis Reference(s)

Journal of the American Chemical Society, 87, p. 4646, 1965 DOI: 10.1021/ja00948a047

Purification Methods

Recrystallise glycine anhydride from H2O (plates) and it can be sublimed (slowly) at 260o or at 140-170o/0.5mm. The dihydrochloride has m 129-130o and is prepared by dissolving it in conc HCl and adding EtOH to crystallisation point; dry it in a vacuum. The bis-1-naphthylurethane has m 232o(dec), and the diperchlorate has m 117o (hygroscopic). [MS: Johnstone J Chem Soc, Perkin Trans 1 1297 1975, NMR: Blaha & Samek Collect Czech Chem Commun 32 3780 1967, Sauborn J Phys Chem 36 179 1932, Corey J Am Chem Soc 60 1599 1938, Beilstein 24 IV 1070.]

GLYCINE ANHYDRIDE Preparation Products And Raw materials

Raw materials

Preparation Products

4-CHLORO-ALPHA-(METHYLAMINO)BENZENE ACETIC ACID
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GLYCINE ANHYDRIDE Suppliers

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View Lastest Price from GLYCINE ANHYDRIDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
GLYCINE ANHYDRIDE 106-57-0
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-12
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
Glycine anhydride 106-57-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2 MTs
Release date
2024-08-06
Career Henan Chemical Co
Product
GLYCINE ANHYDRIDE 106-57-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-24

106-57-0, GLYCINE ANHYDRIDERelated Search:

(S)-3-Isopropyl-2,5-piperazinedione CYCLO(-GLY-SER) CYCLO(-GLY-HIS) CYCLO(-GLY-TRP) cyclo(Gly-Ile) cyclo(Gly-Met) cyclo(Gly-Lys) cyclo(Gly-Arg) cyclo(Gly-Thr) cyclo(Gly-Asn) DL-2-AMINOPROPIONIC ANHYDRIDE GLYCINE ANHYDRIDE 1,4-DIACETYL-2,5-DIKETOPIPERAZINE 1,4-DIMETHYL-2,5-DIKETOPIPERAZINE,Sarcosine diketopiperazine VERRUCULOGEN AMPICILLIN IMP. C (EP):*) AMPICILLIN DIKETOPIPERAZINE MM(CRM STANDARD) Lisinopril R,S,S-Diketopiperazine GLYCINE ANHYDRIDE,2,5-DIKETOPIPERAZINE

  • PIPERAZINE-2,5-DIONE
  • Glycine EP Impurity B
  • Oxiracetam-1
  • 2,5-Dioxopiperazin
  • 2,5-Dioxopiperazine lactam
  • 2,5-Piperazindion
  • alpha,gamma-Diacipiperazine
  • Cyclic(glycylglycyl)
  • Cyclo(glycylglycyl)
  • Cyclodiglycine
  • Diglycolydiamide
  • Diketopiperazine
  • Glycerinanhydrid
  • Glycinanhydrid
  • Glycine, bimol. cyclic peptide
  • 2,5-PIPERAZINE-1,4-DIONE
  • 2,5-Piperazinedione, Cyclo(-Gly-Gly)
  • 2,5-Diketopiperazine, 2,5-Piperazinedione
  • α,γ-piperazinedione
  • Glycine anhydride,98%
  • 2,5-Dioxopiperazine, Glycine anhydride
  • Glycine anhydride, 98% 100GR
  • Glycine anhydride, 98% 25GR
  • Glycine anhydride, 98% 5GR
  • oxiracetaM related substance ISF3890
  • 2,5-Diketopiperazine 2,5-Dioxopiperazine Glycocoll Anhydride 2,5-Piperazinedione
  • 2,5-Piperazinedione, Glycine anhydride, 2,5-Diketopiperazine
  • 2,5-PIPERAZINEDIONE FOR SYNTHESIS
  • Glycine anhydride cyclic dipeptide
  • OxiracetaM IMp. ISF3890
  • Glycine Anhydride (2,5-Piperazinedione)
  • Oxiracetam impurity F
  • Glycine Impurity 2(Glycine EP Impurity B)
  • Oxiracetam impurity ISF3890 (glycine anhydride)
  • AMINOACETIC ACID ANHYDRIDE
  • A-G-DIACIPIPERAZINE
  • CYCLOGLYCYLGLYCINE
  • CYCLO(-GLY-GLY)
  • DIGLYCOLYLDIAMIDE
  • GLYCINANHYDRIDE
  • GLYCOCOLL ANHYDRIDE
  • GLYCINE ANHYDRIDE
  • GLYCYLGLYCINE LACTAM
  • 2,5-DIKETOPIPERAZINE
  • 2,5-DIOXOPIPERAZINE
  • 2,5-PIPERAZINEDIONE
  • Dioxo Piperazine
  • Glycine, N-glycyl-, cyclic peptide
  • Glycylglycinelacton
  • GlycineAnhydride&gt
  • Oxiracetam Related Compound A
  • ycine anhydride
  • GLYCINE ANHYDRIDE USP/EP/BP
  • Piperazine-2,5-dione (Oxiracetam Impurity)
  • 2,5-Piperazinodione
  • Busulfan Impurity1704
  • Oxiracetam impurities1716
  • Glycine Impurity B