Nitrefazole
- Product Name
- Nitrefazole
- CAS No.
- 21721-92-6
- Chemical Name
- Nitrefazole
- Synonyms
- bt-985;ALTIMOL;EMD 15700;NITREFAZOLE;1-(4-NITROPHENYL)-2-METHYL-4-NITROIMIDAZOLE;2-methyl-4-nitro-1-(p-nitrophenyl)-imidazol;2-methyl-4-nitro-1-(4-nitrophenyl)imidazole;2-methyl-4-nitro-1-(4-nitrophenyl)-1h-imidazol;2-Methyl-4-nitro-1-(4-nitrophenyl)-1H-imidazole;1H-Imidazole,2-methyl-4-nitro-1-(4-nitrophenyl)-
- CBNumber
- CB3356045
- Molecular Formula
- C10H8N4O4
- Formula Weight
- 248.19
- MOL File
- 21721-92-6.mol
Nitrefazole Property
- Melting point:
- 185-187°
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- color
- Light Yellow to Yellow
N-Bromosuccinimide Price
- Product number
- N490125
- Product name
- Nitrefazole
- Packaging
- 2.5g
- Price
- $1060
- Updated
- 2021/12/16
- Product number
- 60642
- Product name
- Nitrefazole
- Packaging
- 1g
- Price
- $640
- Updated
- 2021/12/16
- Product number
- API0001431
- Product name
- ALTIMOL
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $641.55
- Updated
- 2021/12/16
Nitrefazole Chemical Properties,Usage,Production
Description
Nitrefazole is an inhibitor of aldehyde dehydrogenase useful in the management of alcoholism. Cited advantages over disulfiram include longer duration of action, higher specificity (no inhibition of dopamine β-hydroxylase) and fewer side effects. It is generally recognized that the efficacy of such agents with respect to permanent abstinence is low. However, temporary abstinence and/or controlled drinking may facilitate supportive psychotherapy and/or delay the onset of severe alcoholic diseases.
Originator
E. Merck (W. Germany)
Uses
Nitrefazole is a nitroimidazole derivative with the ability to inhibit aldehyde dehydrogenase, and enzyme crucial to the metabolism of alcohol. This compound is suitable for aldehyde dehydrogenase (ALDH) related research.
Definition
ChEBI: Nitrefazole is a member of imidazoles.
brand name
ALTIMOL
World Health Organization (WHO)
Nitrefazole, which is used in the treatment of alcoholism, was introduced in the early 1980s. By 1984 its use had been associated with hepatotoxic reactions, some of which were fatal. This led to its withdrawal in at least two countries. WHO has no information to suggest that preparations containing nitrefazole remain commercially available.
Nitrefazole Preparation Products And Raw materials
Raw materials
Preparation Products
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