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Z-TRP-OBZL

Product Name
Z-TRP-OBZL
CAS No.
69876-37-5
Chemical Name
Z-TRP-OBZL
Synonyms
Z-TRP-OBZL;Cbz-Trp-OBzl;Z-L-Trp-OBzl;Z-L-TRYPTOPHAN BENZYL ESTER;N-a-Z-L-tryptophanbenzylester;Nα-Z-L-tryptophan benzyl ester;N-α-Z-L-tryptophan benzyl ester;N-cbz-L-tryptophan benzyl ester;N-.ALPHA.-CBZ-L-TRYPTOPHAN BENZYL ESTER;N-Carbobenzyloxy-L-tryptphan benzyl ester
CBNumber
CB3358438
Molecular Formula
C26H24N2O4
Formula Weight
428.48
MOL File
69876-37-5.mol
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Z-TRP-OBZL Property

Melting point:
105-108℃
Boiling point:
656.7±55.0 °C(Predicted)
Density 
1.266±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
form 
Powder
pka
10.93±0.46(Predicted)
color 
White to off-white
optical activity
7.70°(C=0.01g/mL, CHCL3, 20°C, 589nm)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Activate Scientific
Product number
AS91250
Product name
Nalpha-Cbz-L-tryptophan Benzyl Ester
Purity
97+% ee
Packaging
25g
Price
$221
Updated
2021/12/16
ChemPep
Product number
411802
Product name
Z-Trp-OBzl
Purity
≥98%
Packaging
5g
Price
$293
Updated
2021/12/16
AK Scientific
Product number
V0756
Product name
Z-Trp-OBzl
Packaging
5g
Price
$54
Updated
2021/12/16
Chem-Impex
Product number
06627
Product name
Nα-Z-L-tryptophanbenzylester,99%(HPLC)
Purity
99%(HPLC)
Packaging
25G
Price
$358.4
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0001790
Product name
Z-TRP-OBZL
Purity
95.00%
Packaging
1G
Price
$560
Updated
2021/12/16
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Z-TRP-OBZL Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Synthesis

100-51-6

7432-21-5

69876-37-5

GENERAL STEPS: To a stirred suspension of (S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid (2.45 g, 7.2 mmol) in 10 mL of anhydrous dichloromethane, 4-dimethylaminopyridine (DMAP, 88 mg, 0.72 mmol) and benzyl alcohol (1.28 g, 11.8 mmol) were added. A 5 mL solution of N,N'-dicyclohexylcarbodiimide (DCC, 1.48 g, 7.2 mmol) in dichloromethane was slowly added at 0 °C. The reaction was carried out at 0 °C with the addition of N,N'-dicyclohexylcarbodiimide (DCC, 1.48 g, 7.2 mmol). The reaction mixture was slowly warmed to room temperature and stirred overnight. The white precipitate was removed by filtration and the solvent was subsequently removed by distillation under reduced pressure to afford the colorless oily product Cbz-L-tryptophan benzyl ester (3 g, 98%). The product had a rotativity of [α]D20 = +50 (c = 1.0, CHCl3, 365 nm). Thin layer chromatography (TLC) showed Rf = 0.29 (ethyl acetate:hexane = 1:2).1H NMR (400 MHz, CDCl3) δ: 8.26 (br, 1H), 7.56 (d, J = 8.0 Hz, 1H), 7.41-7.33 (m, 9H), 7.26-7.20 (m, 3H), 7.12 (t, J = 8.0 Hz , 1H), 6.76 (d, J = 2.0 Hz, 1H), 5.47 (d, J = 8.0 Hz, 1H), 5.18-5.10 (m, 4H), 4.82 (q, J = 8.0 Hz, 1H), 3.34 (d, J = 5.1 Hz, 2H).13C NMR (100 MHz, CDCl3) δ: 171.8, 155.8 , 136.1, 136.0, 135.1, 128.5, 128.4, 128.3, 128.0, 127.5, 127.4, 126.9, 122.9, 122.0, 119.5, 118.5, 111.2, 109.4, 67.1, 66.8, 54.6, 27.8.Fourier transform infrared (FTIR) spectroscopy ( FTIR, pure sample) showed absorption peaks located at 3395, 3343, 1742, 1458, 1377, 721 cm-1. High resolution mass spectrometry (HRMS, ESI) calculated value of C20H20O4N2 [M + H]+ was 429.1814 and measured value was 429.1821.

References

[1] Patent: US2011/269972, 2011, A1. Location in patent: Page/Page column 20

Z-TRP-OBZL Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-TRP-OBZL Suppliers

China 80 Germany 2 India 2 Japan 1 Switzerland 1 United Kingdom 3 United States 8 Global 97
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from Z-TRP-OBZL manufacturers

Career Henan Chemical Co
Product
Z-TRP-OBZL 69876-37-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2018-08-09
Career Henan Chemical Co
Product
Z-TRP-OBZL 69876-37-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15

69876-37-5, Z-TRP-OBZLRelated Search:

N-Cbz-L-Tryptophan Z-TRP-NH2 Z-TRP-OME Z-VAL-TRP-OH Z-TRP-OSU Z-TRP(BOC)-OH DCHA Z-PHE-ALA-OH Z-TRP-TRP-OH Z-PHE-TRP-OH Z-SER-NHNH2 Z-TRP-ONP Z-TRP(FOR)-OH Z-Trp(For)-OH.DCHA Z-Trp-Lys(Boc)-NH2 tert-butyl N-[(5S)-6-amino-5-[[(2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]-6-oxohexyl]carbamate N-Cbz-O-tert-butyl-L-serine Z-TYR(TBU)-OH Z-LYS-SBZL HCL

  • N-.ALPHA.-CBZ-L-TRYPTOPHAN BENZYL ESTER
  • N-Carbobenzyloxy-L-tryptphan benzyl ester
  • (S)-benzyl 2-(benzyloxycarbonylamino)-3-(1H-indol-3-yl)propanoate
  • Benzyl (S)-2-(benzyloxycarbonylamino)-3-(1H-indol-3-yl)propanoate
  • N-[(Phenylmethoxy)carbonyl]-L-tryptophan phenylmethyl ester
  • N-ALPHA-CARBOBENZOXY-L-TRYPTOPHAN ALPHA-BENZYL ESTER
  • Z-L-TRYPTOPHAN BENZYL ESTER
  • Z-TRP-OBZL
  • Cbz-Trp-OBzl
  • N-α-Z-L-tryptophan benzyl ester
  • N-a-Z-L-tryptophanbenzylester
  • Nα-Z-L-tryptophan benzyl ester≥ 99% (HPLC)
  • Z-L-Trp-OBzl
  • N-Benzyloxycarbonyl-L-tryptophan benzyl ester
  • benzyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-(1H-indol-3-yl)propanoate
  • L-Tryptophan, N-[(phenylmethoxy)carbonyl]-, phenylmethyl ester
  • Nα-Z-L-tryptophan benzyl ester
  • benzyl (2S)-2-(benzyloxycarbonylamino)-3-(1H-indol-3-yl)prop...
  • N-cbz-L-tryptophan benzyl ester
  • Benzyl N-[(benzyloxy)carbonyl]-L-tryptophanate
  • 69876-37-5
  • C26H24N2O4
  • Tryptophan [Trp, W]
  • Z-Amino Acids and Derivatives
  • Z-Amino acid series