4-Bromophenylboronic acid
- Product Name
- 4-Bromophenylboronic acid
- CAS No.
- 5467-74-3
- Chemical Name
- 4-Bromophenylboronic acid
- Synonyms
- 4-bromophenylboric acid;4-BROMOBENZENEBORONIC ACID;p-BBBA;NSC 25407;AKOS BRN-0005;RARECHEM AH PB 0075;4-Bromophenylboronic;p-bromophenylboricacid;Flortaucipir Impurity 25;4-BROMOPHENYLBORONIC ACID
- CBNumber
- CB3361760
- Molecular Formula
- C6H6BBrO2
- Formula Weight
- 200.83
- MOL File
- 5467-74-3.mol
4-Bromophenylboronic acid Property
- Melting point:
- 284-288 °C (lit.)
- Boiling point:
- 315.0±44.0 °C(Predicted)
- Density
- 1.67±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Crystalline Powder
- pka
- 8.32±0.10(Predicted)
- color
- Off-white to light beige
- Water Solubility
- Soluble in methanol. Insoluble in water.
- BRN
- 2936347
- InChI
- InChI=1S/C6H6BBrO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H
- InChIKey
- QBLFZIBJXUQVRF-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(Br)C=C1)(O)O
- CAS DataBase Reference
- 5467-74-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- CY8650000
- TSCA
- T
- HazardClass
- IRRITANT
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B75956
- Product name
- 4-Bromophenylboronic acid
- Purity
- ≥95.0%
- Packaging
- 5g
- Price
- $88.2
- Updated
- 2025/07/31
- Product number
- B1858
- Product name
- 4-Bromophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- B1858
- Product name
- 4-Bromophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $51
- Updated
- 2025/07/31
- Product number
- B1858
- Product name
- 4-Bromophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $143
- Updated
- 2025/07/31
- Product number
- B686545
- Product name
- 4-Bromophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 100g
- Price
- $1075
- Updated
- 2021/12/16
4-Bromophenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
suzuki reaction
Uses
4-Bromobenzeneboronic acid is a reagent used for Palladium catalyzed Suzuki-Miyaura cross-couplings, Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation sequence. It is also used in the preparation of Protein modulators and enzymatic and kinase inhibitors, Gallate-based obovatol analogs with potential anti-tumor activity. It is used as a reagent for Copper-mediated ligandless aerobic fluoroalkylation of arylboronic acids with fluoroalkyl iodides, Pd-catalyzed arylative cyclization of alkyne-tethered enals or enones via carbopalladation of alkynes, Copper-catalyzed cross-couplings.
Uses
Labelled 4-Bromophenylboronic Acid (B686545). 4-Bromophenylboric acid is used in the preparation of arylboronates as inhibitors of fatty acid amide hydrolase.
Synthesis
106-40-1
5467-74-3
GENERAL METHOD: 4-Bromoaniline (0.5 mmol, 1.0 eq.) was dissolved in methanol (1.0 mL), hydrochloric acid (0.5 mL, 1.5 mmol, 3.0 eq.) and water (0.5 mL) were added. The reaction mixture was stirred for 2 min and then sodium nitrite solution (0.25 mL, prepared by dissolving 35 mg of sodium nitrite in 0.25 mL of water) was added. Stir at 0-5 °C for 30 min, followed by the addition of hydrochloric acid (135 mg, 1.5 mmol, 3.0 equiv) in methanol (1.0 mL). Stirring was continued for 60 min. After completion of the reaction, it was diluted with water (10 mL) and extracted with dichloromethane (50 mL, 3 times). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 4-bromophenylboronic acid.
References
[1] Synlett, 2014, vol. 25, # 11, p. 1577 - 1584
[2] Chemistry - A European Journal, 2014, vol. 20, # 22, p. 6608 - 6612
4-Bromophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromophenylboronic acid Suppliers
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View Lastest Price from 4-Bromophenylboronic acid manufacturers
- Product
- 4-Bromophenylboronic acid 5467-74-3
- Price
- US $1.50/g
- Min. Order
- 1g
- Purity
- 99.0% Min
- Supply Ability
- 10 Tons
- Release date
- 2025-06-24
- Product
- 4-Bromophenylboronic acid 5467-74-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-25
- Product
- 4-Bromophenylboronic acid 5467-74-3
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2024-08-21