2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE

Product Name: 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE
CAS No.: 209256-42-8
Chemical Name: 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE
Synonyms: Tasimelteon INT;Tasimelteon intermediate;2,3-DIHYDRO-BENZOFURAN-4-CARBALDEHYDE;2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE;2,3-dihydro-1-benzofuran-4-carbaldehyde;4-Benzofurancarboxaldehyde, 2,3-dihydro-;4-Benzofurancarboxaldehyde, 2,3-dihydro- (9CI)
CBNumber: CB3368204
Molecular Formula: C9H8O2
Formula Weight: 148.16
MOL File: 209256-42-8.mol

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2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Property

Boiling point:: 276℃
Density: 1.222
Flash point:: 132℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D446965
Product name: 2,3-Dihydrobenzofuran-4-carbaldehyde
Packaging: 250mg
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: 0701AB
Product name: 2,3-Dihydrobenzofuran-4-carbaldehyde
Packaging: 250mg
Price: $143
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD139110
Product name: 2,3-Dihydro-4-benzofurancarboxaldehyde
Packaging: 500mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD139110
Product name: 2,3-Dihydro-4-benzofurancarboxaldehyde
Packaging: 250mg
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: 0701AB
Product name: 2,3-Dihydrobenzofuran-4-carbaldehyde
Packaging: 100mg
Price: $126
Updated: 2021/12/16

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2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Chemical Properties,Usage,Production

Uses

2,3-Dihydrobenzofuran-4-carbaldehyde is used in the synthesis of macroline derivatives as inhibitors of mycobacterium tuberculosis protein tyrosine phosphatase B.

Synthesis

209256-41-7

209256-42-8

The general procedure for the synthesis of 2,3-dihydrobenzofuran-4-carbaldehyde from 4-hydroxymethyl-benzodihydrofuran was as follows: a dichloromethane solution (40 mL, 2 M) of oxalyl chloride was stirred at -78 °C and DMSO (8.10 mL, 114 mmol) was slowly added. Subsequently, a dichloromethane solution (35 mL) of 4-hydroxymethyl-benzodihydrofuran (8.53 g, 56.9 mmol) was added dropwise and stirring was continued for 30 min at -78 °C. Upon completion of the reaction, triethylamine (33 mL, 228 mmol) was carefully added to quench the reaction. The resulting suspension was stirred at room temperature for 30 min and then diluted with dichloromethane (100 mL). The organic layer was washed three times with water and twice with brine sequentially, and finally concentrated by vacuum to give 2,3-dihydrobenzofuran-4-carbaldehyde as an oil (8.42 g, 100%), which could be used for subsequent reactions without further purification.

References

[1] Patent: EP1041980, 2005, B1. Location in patent: Page 17
[2] Patent: EP1027043, 2004, B1. Location in patent: Page/Page column 17

2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Suppliers

China 70 Europe 1 France 1 Germany 1 India 1 Ukraine 1 United Kingdom 1 United States 15 Global 91

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Beijing Yisiyan Technology Research Center

Tel: 010-56645598 13366904824
Fax: 01062230033
Email: bjkaida@163.com
Country: China
ProdList: 1618
Advantage: 59

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Wuhan Chemduro Pharm Tech Co. Ltd.

Tel: 18040571231/1402788087
Fax: sales@chemduro.com
Country: China
ProdList: 1973
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Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
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Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
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JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12000
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Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
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Advantage: 65

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
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View Lastest Price from 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE manufacturers

PNP Biotech Co. Ltd

Product: Tasimelteon INT 209256-42-8
Price: US $0.00/KG
Min. Order: 25KG
Purity: 95%
Supply Ability: Inquiry
Release date: 2023-03-30

Career Henan Chemical Co

Product: 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE 209256-42-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-02

209256-42-8, 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDERelated Search:

RIFAMYCIN 2,3-dihydrobenzofuran-4-carboxylic acid 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE 10-ketonaltrexone 4-Formyl-2,3,6,7-Tetrahydrobenzo[1,2-B:4,5-B']Difuran kanglemycin A RIFAMPIN QUINONE (50 MG) 10-Oxo Morphine 2,3-Dihydro-5-benzofurancarboxaldehyde 1-(2-METHYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-ETHANONE 1-(3-ETHYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-ETHANONE GRANATIN B Rifamycin S Sodium RIFAMYCIN S-SODIUM SALT (4-FORMYL-2,3-DIHYDRO-BENZOFURAN-3-YL)-ACETIC ACID METHYL ESTER 3-METHYL-2,3-DIHYDRO-BENZOFURAN-4-CARBALDEHYDE 1-(3-METHYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-ETHANONE

2,3-DIHYDRO-BENZOFURAN-4-CARBALDEHYDE

2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE

4-Benzofurancarboxaldehyde, 2,3-dihydro- (9CI)

4-Benzofurancarboxaldehyde, 2,3-dihydro-

Tasimelteon INT

2,3-dihydro-1-benzofuran-4-carbaldehyde

Tasimelteon intermediate

209256-42-8

C9H8NO2

ALDEHYDE