1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Product Name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
CAS No.: 196597-78-1
Chemical Name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
Synonyms: 6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-one;RaMelteon I;8H-Indeno[5;Ramelteon-1;7-tetrahydro-;4-b]furan-8-one;Ramelteon Imputiry A;Ramelteon Intermediate 1;7-Tetrahydro-8H-indeno[5;tetrahydroindenobfuranone
CBNumber: CB71175443
Molecular Formula: C11H10O2
Formula Weight: 174.2
MOL File: 196597-78-1.mol

More

Less

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Property

Melting point:: 149-1510C
Boiling point:: 334.2±42.0 °C(Predicted)
Density: 1.288±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1S/C11H10O2/c12-9-3-1-7-2-4-10-8(11(7)9)5-6-13-10/h2,4H,1,3,5-6H2
InChIKey: ZZUIZMWFNOKNLN-UHFFFAOYSA-N
SMILES: O1CCC2=C3C(CCC3=O)=CC=C12
CAS DataBase Reference: 196597-78-1(CAS DataBase Reference)

More

Less

Safety

HS Code: 2932.99.7000
HazardClass: IRRITANT

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: D5069
Product name: 6,7-Dihydro-1H-indeno[5,4-b]furan-8(2H)-one
Purity: >98.0%(GC)
Packaging: 200mg
Price: $90
Updated: 2025/07/31

TCI Chemical

Product number: D5069
Product name: 6,7-Dihydro-1H-indeno[5,4-b]furan-8(2H)-one
Purity: >98.0%(GC)
Packaging: 1g
Price: $271
Updated: 2025/07/31

TRC

Product number: T293700
Product name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
Packaging: 500mg
Price: $280
Updated: 2021/12/16

TRC

Product number: T293700
Product name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
Packaging: 50mg
Price: $120
Updated: 2021/12/16

TRC

Product number: T293700
Product name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
Packaging: 250mg
Price: $215
Updated: 2021/12/16

More

Less

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A tricyclic indan derivative as receptor agonist; a therapeutic agent for sleep disorders.

Synthesis

196597-77-0

196597-78-1

4,5-Dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one (280 kg, 843 mol) was used as a raw material, mixed with anhydrous sodium acetate (173 kg, 2109 mol) and methanol (6384 L). After the reaction system was replaced with nitrogen, 10% Pd/C catalyst (30.8 kg, dry weight) was added. Subsequently, the reaction mixture was pressurized to 0.29 to 0.49 MPa under a hydrogen atmosphere and catalytically reduced for 8 hours at about 40°C with a stirring rate such that the total gas-liquid mass transfer coefficient, KLa (1/hr), was about 15. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. Water was added to the concentrated residue, concentrated again under reduced pressure to displace the solvent, cooled and stirred for 1 hour to mature the crystals. The crystallized solution was filtered to give wet 1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one crystals (dry weight 127 kg, yield 86.6%). The amount of dimer in the wet crystals was less than 0.1 wt%.

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 19, p. 4222 - 4239
[2] Patent: EP1199304, 2002, A1. Location in patent: Referential example 18
[3] Patent: EP1792899, 2007, A1. Location in patent: Page/Page column 13
[4] Patent: CN103570651, 2016, B. Location in patent: Paragraph 0063; 0064
[5] Patent: US6348485, 2002, B1

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Suppliers

Americas 1 Canada 2 China 230 China Hong Kong 1 Europe 1 Germany 2 India 23 Japan 1 United Kingdom 2 United States 12 Global 275

Beijing Whale Technology Corporation Ltd.

Tel: 010-83694934 13671295325
Email: sales@whalecorporation.com
Country: China
ProdList: 109
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
Fax: QQ:115820162
Email: zwchem@163.com
Country: China
ProdList: 617
Advantage: 61

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

More

Less

View Lastest Price from 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one 196597-78-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-01-24

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Ramelteon Imputiry A 196597-78-1
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2024-05-27

Shaanxi Dideu Medichem Co. Ltd

Product: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one 196597-78-1
Price: US $5876.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1T
Release date: 2020-06-28

196597-78-1, 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-oneRelated Search:

Ninhydrine, ozone friendly ready to use spray for TLC chromatography Furan Ninhydrin hydrate (R)-Ramelteon Acetonitrile, (1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)-, (2E)- 4,5-Dibromo-1,2,6,7-tertahydro-8H-indeno[5,4-b]furan-8-one Ramelteon Impurity 10 (R)-2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)acetic acid Ramelteon Impurity 6 4-Acetyl RaMelteon Ramelteon 2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate (R,R)-1,2-bis(methanesulfonyloxymethyl)cyclohexane 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE 7-METHYL-1-INDANONE 6 ETHOXY-1-INDANONE 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

1,2,6,7-Tetrahydro-8H-indeno[5,4-β]furan-8-one

RaMelteon I

4-b]furan-8-one

7-tetrahydro-

8H-Indeno[5

1,2,6,7-tetrahydroindeno[5,4-b]furan-8-one

Ramelteon Intermediate 1

8H-Indeno[5,4-b]furan-8-one, 1,2,6,7-tetrahydro-

6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-one

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan...

1,2,6,7-Tetrahydro-8H-indenofuran-8-one

(S)-N-[2-(1,6,7,8-Tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethylamine

1,2,6,7-tetrahydrocyclopenta[e][1]benzofuran-8-one

6,7-Dihydro-1H-indeno[5,4-b]furan-8(2H)-one

ethyl 3-(2,3-dihydrobenzofuran-4-yl)propanoate

tetrahydroindenobfuranone

Ramelteon Imputiry A

Ramelteon-1

1,2,6,7-tetrahydrocyclopenta[e]benzofuran-8-one

7-Tetrahydro-8H-indeno[5

1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-

1,2,6,7-Tetrahydro-8H-indeno[5,4-d]furan-8-one

1,2,6,7-tetrahydroindeno[5,4-b]furan-8-one, 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

196597-78-1

Heterocycles

Aromatics Compounds

Aromatics