2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Product Name: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate
CAS No.: 160969-03-9
Chemical Name: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate
Synonyms: Silodosin KSM-2;Silodosin Impurty 1;Silodosin side chain;Silodosin Impurity 35;Silodosin Impurity 44;Silodosin Intermediate 1;2-(2-(2,2,2-Trifluoroethoxy);2-(2-TRIFLUOROETHOXYPHENOXY)ETHYLMETHANESULFONATE;2-[2-(2,2,2-Trifluoro-ethoxy)phenoxy]-ethyl mesylate;2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfote
CBNumber: CB82470982
Molecular Formula: C11H13F3O5S
Formula Weight: 314.28
MOL File: 160969-03-9.mol

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2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate Property

Melting point:: 52.0 to 56.0 °C
Boiling point:: 396.4±42.0 °C(Predicted)
Density: 1.362
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1S/C11H13F3O5S/c1-20(15,16)19-7-6-17-9-4-2-3-5-10(9)18-8-11(12,13)14/h2-5H,6-8H2,1H3
InChIKey: HOJMCBMXHWZNKX-UHFFFAOYSA-N
SMILES: C(OS(C)(=O)=O)COC1=CC=CC=C1OCC(F)(F)F

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Safety

HS Code: 2909.30.6000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T3505
Product name: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate
Purity: >98.0%(GC)
Packaging: 1g
Price: $19
Updated: 2026/03/19

TCI Chemical

Product number: T3505
Product name: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate
Purity: >98.0%(GC)
Packaging: 5g
Price: $61
Updated: 2026/03/19

TRC

Product number: T790290
Product name: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate
Packaging: 2.5g
Price: $460
Updated: 2021/12/16

AK Scientific

Product number: J98381
Product name: 2-[2-Trifluoroethoxyphenoxy]ethylmethanesulfonate
Packaging: 10g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 090861
Product name: 2-(2-(2,2,2-Trifluoroethoxy)phenoxy)-ethyl methanesulfonate
Purity: 95+%
Packaging: 250mg
Price: $288
Updated: 2021/12/16

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2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate Chemical Properties,Usage,Production

Uses

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate is an intermediate of Silodosin (S465000) which is an α1a-adrenoceptor antagonist and used in the treatment of benign prostatic hypertophy.

Synthesis

Anhydrous AlCl3 ( 165 g, 1 .24 mol) and 200 mL of anhydrous dichloromethane were mixed, cooled to -5 under nitrogen protection, methane sulfonyl chloride was added dropwise with stirring, and then stirred at room temperature for 30 min after the dropwise addition, a solution of 2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanol ( 100 g, 0.62 mol) in dichloromethane ( 70 mL) was added dropwise with stirring at room temperature after the dropwise addition, and the internal temperature was not more than 5 . The internal temperature was not more than 5 , and the reaction progress was detected by thin-layer chromatography after the dropwise addition and stirring at room temperature for 30 h. The reaction solution was slowly poured into 800 mL of ice water with stirring, and the organic layer was separated, the aqueous layer was extracted with dichloromethane (6 120 mL), and the organic layers were combined, washed with saturated brine, saturated sodium bicarbonate solution and dried with anhydrous sodium sulfate, and then filtered, and the filtrate was concentrated. Ethyl acetate. The target compound 2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl methanesulfonate.

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate Suppliers

China 241 India 17 Japan 1 United Kingdom 1 United States 9 Global 269

Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd

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ProdList: 94
Advantage: 58

Suzhou Daolan Biomedical Technology Co., Ltd.

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JinYan Chemicals(ShangHai) Co.,Ltd.

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Nanjing Chemlin Chemical Co., Ltd

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XiaoGan ShenYuan ChemPharm co,ltd

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Nanjing Chemipioneer Pharma& Tech Co., LTD

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Syntechem Co.,Ltd

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View Lastest Price from 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate manufacturers

Moxin Chemicals

Product: Ezetimibe Impurity94 160969-03-9
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 99%+ HPLC
Supply Ability: 1000
Release date: 2025-06-27

Shaanxi Dideu New Materials Co. Ltd

Product: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethanol1-methanesulfonate 160969-03-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-14

Shaanxi Dideu Medichem Co. Ltd

Product: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate 160969-03-9
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20000KG
Release date: 2020-01-09

160969-03-9, 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonateRelated Search:

Silodosin Impurity 26 PSI-6130 derivative Pyrazine-2,5-dicarboxylic acid (1s-trans)-2-[(phenylmethoxy)methyl]-3-cyclopenten-1-ol ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate (R)-(+)-1-(1-Naphthyl)ethylamine Pregabalin 5-Fluoro-2-nitroanisole 5-Aminolevulinic acid hydrochloride Clopidogrel hydrogen sulfate Ethyl (3R)-piperidine-3-carboxylate 4-Hydroxypiperidine (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one 4,5-Dimethoxy-1-cyanobenzocyclobutane (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Silodosin 5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Silodosin Intermediate 1

2-[2-(2,2,2-trifluoroethoxy)phenoxy]-ethanol-1-Methanesulfonate

2-(2-TRIFLUOROETHOXYPHENOXY)ETHYLMETHANESULFONATE

Ethanol,2-[2-(2,2,2-trifluoroethoxy)phenoxy]-, 1-Methanesulfonate

2-(2-(2,2,2-Trifluoroethoxy)

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfote

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate(for Silodoxin)

methanesulfonic acid 2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl ester

Silodosin Impurty 1

Silodosin Impurity 35

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate(For export only)

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate [160969-03-9]

Silodosin Impurity 44

Silodosin KSM-2

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonateQ: What is 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate Q: What is the CAS Number of 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate Q: What is the storage condition of 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate Q: What are the applications of 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate (Silodosin Intermediate)

2[2(2,2,2Trifluoroethoxy)phenoxy]ethyl methanesulfonate,2 [2 (2,2,2 Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Silodosin side chain

2-[2-(2,2,2-Trifluoroethoxy)phenoxyJethyl methanesulfonate

2- [2- (2,2,2-trifluoroethoxy) phenoxy] ethyl methanesulfonate (Siloxacin A)

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate, 10 mM in DMSO

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethylmethanesulfonate(SilodosinIntermediateA)

2-[2-(2,2,2-Trifluoro-ethoxy)phenoxy]-ethyl mesylate

160969-03-9

60969-03-9

C11H13F3O5S