1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Product Name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
CAS No.: 196597-78-1
Chemical Name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
Synonyms: 6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-one;RaMelteon I;8H-Indeno[5;Ramelteon-1;7-tetrahydro-;4-b]furan-8-one;Ramelteon Imputiry A;Ramelteon Intermediate 1;7-Tetrahydro-8H-indeno[5;tetrahydroindenobfuranone
CBNumber: CB71175443
Molecular Formula: C11H10O2
Formula Weight: 174.2
MOL File: 196597-78-1.mol

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1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Property

Melting point:: 149-1510C
Boiling point:: 334.2±42.0 °C(Predicted)
Density: 1.288±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1S/C11H10O2/c12-9-3-1-7-2-4-10-8(11(7)9)5-6-13-10/h2,4H,1,3,5-6H2
InChIKey: ZZUIZMWFNOKNLN-UHFFFAOYSA-N
SMILES: O1CCC2=C3C(CCC3=O)=CC=C12
CAS DataBase Reference: 196597-78-1(CAS DataBase Reference)

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Safety

HS Code: 2932.99.7000
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5069
Product name: 6,7-Dihydro-1H-indeno[5,4-b]furan-8(2H)-one
Purity: >98.0%(GC)
Packaging: 200mg
Price: $90
Updated: 2025/07/31

TCI Chemical

Product number: D5069
Product name: 6,7-Dihydro-1H-indeno[5,4-b]furan-8(2H)-one
Purity: >98.0%(GC)
Packaging: 1g
Price: $271
Updated: 2025/07/31

TRC

Product number: T293700
Product name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
Packaging: 50mg
Price: $120
Updated: 2021/12/16

TRC

Product number: T293700
Product name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
Packaging: 250mg
Price: $215
Updated: 2021/12/16

TRC

Product number: T293700
Product name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
Packaging: 500mg
Price: $280
Updated: 2021/12/16

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1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A tricyclic indan derivative as receptor agonist; a therapeutic agent for sleep disorders.

Synthesis

196597-77-0

196597-78-1

4,5-Dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one (280 kg, 843 mol) was used as a raw material, mixed with anhydrous sodium acetate (173 kg, 2109 mol) and methanol (6384 L). After the reaction system was replaced with nitrogen, 10% Pd/C catalyst (30.8 kg, dry weight) was added. Subsequently, the reaction mixture was pressurized to 0.29 to 0.49 MPa under a hydrogen atmosphere and catalytically reduced for 8 hours at about 40°C with a stirring rate such that the total gas-liquid mass transfer coefficient, KLa (1/hr), was about 15. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. Water was added to the concentrated residue, concentrated again under reduced pressure to displace the solvent, cooled and stirred for 1 hour to mature the crystals. The crystallized solution was filtered to give wet 1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one crystals (dry weight 127 kg, yield 86.6%). The amount of dimer in the wet crystals was less than 0.1 wt%.

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 19, p. 4222 - 4239
[2] Patent: EP1199304, 2002, A1. Location in patent: Referential example 18
[3] Patent: EP1792899, 2007, A1. Location in patent: Page/Page column 13
[4] Patent: CN103570651, 2016, B. Location in patent: Paragraph 0063; 0064
[5] Patent: US6348485, 2002, B1

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Suppliers

Americas 1 Canada 2 China 231 China Hong Kong 1 Europe 1 Germany 2 India 23 Japan 1 United Kingdom 2 United States 12 Global 276

BTC pharm India

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View Lastest Price from 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one 196597-78-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-01-24

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Ramelteon Imputiry A 196597-78-1
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2024-05-27

Shaanxi Dideu Medichem Co. Ltd

Product: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one 196597-78-1
Price: US $5876.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1T
Release date: 2020-06-28

196597-78-1, 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-oneRelated Search:

Ninhydrine, ozone friendly ready to use spray for TLC chromatography Furan Ninhydrin hydrate (R)-Ramelteon Acetonitrile, (1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)-, (2E)- 4,5-Dibromo-1,2,6,7-tertahydro-8H-indeno[5,4-b]furan-8-one Ramelteon Impurity 10 (R)-2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)acetic acid Ramelteon Impurity 6 4-Acetyl RaMelteon Ramelteon 2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate (R,R)-1,2-bis(methanesulfonyloxymethyl)cyclohexane 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE 7-METHYL-1-INDANONE 6 ETHOXY-1-INDANONE 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

1,2,6,7-Tetrahydro-8H-indeno[5,4-β]furan-8-one

RaMelteon I

4-b]furan-8-one

7-tetrahydro-

8H-Indeno[5

1,2,6,7-tetrahydroindeno[5,4-b]furan-8-one

Ramelteon Intermediate 1

8H-Indeno[5,4-b]furan-8-one, 1,2,6,7-tetrahydro-

6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-one

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan...

1,2,6,7-Tetrahydro-8H-indenofuran-8-one

(S)-N-[2-(1,6,7,8-Tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethylamine

1,2,6,7-tetrahydrocyclopenta[e][1]benzofuran-8-one

6,7-Dihydro-1H-indeno[5,4-b]furan-8(2H)-one

ethyl 3-(2,3-dihydrobenzofuran-4-yl)propanoate

tetrahydroindenobfuranone

Ramelteon Imputiry A

Ramelteon-1

1,2,6,7-tetrahydrocyclopenta[e]benzofuran-8-one

7-Tetrahydro-8H-indeno[5

1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-

1,2,6,7-Tetrahydro-8H-indeno[5,4-d]furan-8-one

1,2,6,7-tetrahydroindeno[5,4-b]furan-8-one, 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

196597-78-1

Heterocycles

Aromatics Compounds

Aromatics