ChemicalBook > CAS DataBase List > 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE

2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE

Product Name
2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE
CAS No.
209256-42-8
Chemical Name
2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE
Synonyms
Tasimelteon INT;Tasimelteon intermediate;2,3-DIHYDRO-BENZOFURAN-4-CARBALDEHYDE;2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE;2,3-dihydro-1-benzofuran-4-carbaldehyde;4-Benzofurancarboxaldehyde, 2,3-dihydro-;4-Benzofurancarboxaldehyde, 2,3-dihydro- (9CI)
CBNumber
CB3368204
Molecular Formula
C9H8O2
Formula Weight
148.16
MOL File
209256-42-8.mol
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2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Property

Boiling point:
276℃
Density 
1.222
Flash point:
132℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
Light yellow to yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D446965
Product name
2,3-Dihydrobenzofuran-4-carbaldehyde
Packaging
250mg
Price
$160
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD139110
Product name
2,3-Dihydro-4-benzofurancarboxaldehyde
Packaging
250mg
Price
$100
Updated
2021/12/16
AK Scientific
Product number
0701AB
Product name
2,3-Dihydrobenzofuran-4-carbaldehyde
Packaging
100mg
Price
$126
Updated
2021/12/16
AK Scientific
Product number
0701AB
Product name
2,3-Dihydrobenzofuran-4-carbaldehyde
Packaging
250mg
Price
$143
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD139110
Product name
2,3-Dihydro-4-benzofurancarboxaldehyde
Packaging
500mg
Price
$150
Updated
2021/12/16
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2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Chemical Properties,Usage,Production

Uses

2,3-Dihydrobenzofuran-4-carbaldehyde is used in the synthesis of macroline derivatives as inhibitors of mycobacterium tuberculosis protein tyrosine phosphatase B.

Synthesis

209256-41-7

209256-42-8

The general procedure for the synthesis of 2,3-dihydrobenzofuran-4-carbaldehyde from 4-hydroxymethyl-benzodihydrofuran was as follows: a dichloromethane solution (40 mL, 2 M) of oxalyl chloride was stirred at -78 °C and DMSO (8.10 mL, 114 mmol) was slowly added. Subsequently, a dichloromethane solution (35 mL) of 4-hydroxymethyl-benzodihydrofuran (8.53 g, 56.9 mmol) was added dropwise and stirring was continued for 30 min at -78 °C. Upon completion of the reaction, triethylamine (33 mL, 228 mmol) was carefully added to quench the reaction. The resulting suspension was stirred at room temperature for 30 min and then diluted with dichloromethane (100 mL). The organic layer was washed three times with water and twice with brine sequentially, and finally concentrated by vacuum to give 2,3-dihydrobenzofuran-4-carbaldehyde as an oil (8.42 g, 100%), which could be used for subsequent reactions without further purification.

References

[1] Patent: EP1041980, 2005, B1. Location in patent: Page 17
[2] Patent: EP1027043, 2004, B1. Location in patent: Page/Page column 17

2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Suppliers

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View Lastest Price from 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE manufacturers

PNP Biotech Co. Ltd
Product
Tasimelteon INT 209256-42-8
Price
US $0.00/KG
Min. Order
25KG
Purity
95%
Supply Ability
Inquiry
Release date
2023-03-30
Career Henan Chemical Co
Product
2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE 209256-42-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-02

209256-42-8, 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDERelated Search:

RIFAMYCIN 2,3-dihydrobenzofuran-4-carboxylic acid 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE 10-ketonaltrexone 4-Formyl-2,3,6,7-Tetrahydrobenzo[1,2-B:4,5-B']Difuran kanglemycin A RIFAMPIN QUINONE (50 MG) 10-Oxo Morphine 2,3-Dihydro-5-benzofurancarboxaldehyde 1-(2-METHYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-ETHANONE 1-(3-ETHYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-ETHANONE GRANATIN B Rifamycin S Sodium RIFAMYCIN S-SODIUM SALT (4-FORMYL-2,3-DIHYDRO-BENZOFURAN-3-YL)-ACETIC ACID METHYL ESTER 3-METHYL-2,3-DIHYDRO-BENZOFURAN-4-CARBALDEHYDE 1-(3-METHYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-ETHANONE

  • 2,3-DIHYDRO-BENZOFURAN-4-CARBALDEHYDE
  • 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE
  • 4-Benzofurancarboxaldehyde, 2,3-dihydro- (9CI)
  • 4-Benzofurancarboxaldehyde, 2,3-dihydro-
  • Tasimelteon INT
  • 2,3-dihydro-1-benzofuran-4-carbaldehyde
  • Tasimelteon intermediate
  • 209256-42-8
  • C9H8NO2
  • ALDEHYDE