5,5-Dimethyloxazolidine-2,4-dione Property

Melting point:

77-80 °C (lit.)

Boiling point:

137 °C / 6mmHg

Density 

1.3816 (rough estimate)

refractive index 

1.4220 (estimate)

storage temp. 

2-8°C

solubility 

Chloroform, Ethyl Acetate

form 

Crystalline Powder

pka

6.13(at 37℃)

color 

White

Merck 

14,3213

BRN 

113541

InChIKey

JYJFNDQBESEHJQ-UHFFFAOYSA-N

CAS DataBase Reference

695-53-4(CAS DataBase Reference)

NIST Chemistry Reference

5,5-Dimethyloxazolidine-2,4-dione(695-53-4)

EPA Substance Registry System

2,4-Oxazolidinedione, 5,5-dimethyl- (695-53-4)

Safety

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-40-33-36/37/38

Safety Statements 

22-36-24/25-23-36/37-26

WGK Germany 

3

RTECS 

RP9100000

TSCA 

Yes

HS Code 

29349990

Toxicity

LD50 i.v. in mice: 450 mg/kg (Stoughton)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

5,5-Dimethyloxazolidine-2,4-dione Chemical Properties,Usage,Production

Chemical Properties

5,5-Dimethyloxazolidine-2,4-dione is white crystalline powder

Uses

5,5-Dimethyloxazolidine-2,4-dione is in vivo measurement of intracellular pH.

Uses

Reactant involved in:• ;Synthesis of nickel benzoannulated or naphthoannulated β-oxatetraazachlorin complex1• ;Being used as a cathepsin K inhibitor2Molecule involved in pharmacological studies including:• ;Identification of bioequivalent generic substitute for antiepileptic drugs3• ;Screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis4• ;Dissolving protein plugs in patients with choledochal cyst / pancreaticobiliary maljunctions5

Uses

anticonvulsant

Definition

ChEBI: 5,5-dimethyloxazolidine-2,4-dione is an oxazolidinone.

Safety Profile

Moderately toxic by intraperitoneal and intravenous routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx. Used as an anticonvulsant.