ChemicalBook > CAS DataBase List > 4-Bromo-2-fluorobenzaldehyde
4-Bromo-2-fluorobenzaldehyde
- Product Name
- 4-Bromo-2-fluorobenzaldehyde
- CAS No.
- 57848-46-1
- Chemical Name
- 4-Bromo-2-fluorobenzaldehyde
- Synonyms
- 2-FLUORO-4-B;4-Bromo-2-fluoro benzelhyde;4-BROMO-2-FLUOROBENZALDEHYDE;2-FLUORO-4-BROMOBENZALEDHYDE;2-FLUORO-4-BROMOBENZALDEHYDE;Benzaldehyde, 4-bromo-2-fluoro-;4-Bromo-2-fluorobenzaldehyde98%;4-Bromo-2-fluorobenzaldehyde,96%;4-Bromo-2-fluorobenzaldehyde 98%;4-Bromo-2-fluorobenzaldehyde >
- CBNumber
- CB3377073
- Molecular Formula
- C7H4BrFO
- Formula Weight
- 203.01
- MOL File
- 57848-46-1.mol
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4-Bromo-2-fluorobenzaldehyde Property
- Melting point:
- 58-62 °C (lit.)
- Boiling point:
- 42°C 19mm
- Density
- 1.6698 (rough estimate)
- refractive index
- 1.5700 (estimate)
- Flash point:
- 42°C/19mm
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Orange to Green
- Water Solubility
- INSOLUBLE
- Sensitive
- Air Sensitive
- BRN
- 7700208
- InChI
- InChI=1S/C7H4BrFO/c8-6-2-1-5(4-10)7(9)3-6/h1-4H
- InChIKey
- UPCARQPLANFGQJ-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=C(Br)C=C1F
- CAS DataBase Reference
- 57848-46-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Fluoro-4-bromobenzaldehyde(57848-46-1)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, AIR SENSITIVE
- HS Code
- 29130000
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 465232
- Product name
- 4-Bromo-2-fluorobenzaldehyde
- Purity
- 96%
- Packaging
- 5g
- Price
- $25
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 465232
- Product name
- 4-Bromo-2-fluorobenzaldehyde
- Purity
- 96%
- Packaging
- 25g
- Price
- $119
- Updated
- 2023/06/20
TCI Chemical
- Product number
- B2002
- Product name
- 4-Bromo-2-fluorobenzaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $61
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B2002
- Product name
- 4-Bromo-2-fluorobenzaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $174
- Updated
- 2025/07/31
TRC
- Product number
- B684520
- Product name
- 4-Bromo-2-fluorobenzaldehyde
- Packaging
- 100g
- Price
- $1055
- Updated
- 2021/12/16
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4-Bromo-2-fluorobenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
lightyellowtobeigecrystal
Uses
4-Bromo-2-fluorobenzaldehyde is used in the preparation of nigeglanine hydrobromide.
Uses
4-Bromo-2-fluorobenzaldehyde has been used in the preparation of:
- 2-functionalized aromatic monoaldehydes, via reaction with different secondary amines and phenol
- fluorostilbenes
- benzyl amine-based histamine H3 antagonist having serotonin reuptake activity
- 6-bromo-2-(4-bromo-2-fluorophenyl)-2,3-dihydro-4H-chromen-4-one
Uses
4-Bromo-2-fluorobenzaldehyde is used in the synthesis of Nigeglanine hydrobromide.
Synthesis
222978-01-0
57848-46-1
General procedure for the synthesis of 4-bromo-2-fluorobenzaldehyde from 4-bromo-3-fluorobenzyl alcohol: To a solution of 4-bromo-3-fluorobenzyl alcohol (7.9 g, 38.5 mmol) in dichloromethane (160.0 mL) was added sodium acetate (940 mg, 11.5 mmol) and pyridinium chlorochromate (10.8 g, 50.0 mmol) sequentially. The reaction mixture was stirred at room temperature and protected from light for 2 hours. After completion of the reaction, the mixture was diluted with ethyl acetate (1.0 L) and filtered through a diatomaceous earth pad. The filtrate was washed sequentially with aqueous sodium bicarbonate (600 mL) and water (600 mL) and subsequently dried with anhydrous sodium sulfate. After evaporation of the solvent under reduced pressure, the resulting crude product was further purified by column chromatography to afford 4-bromo-2-fluorobenzaldehyde as a white solid (5.0 g, 63% yield).
References
[1] Patent: WO2011/21209, 2011, A1. Location in patent: Page/Page column 38; 39
[2] Patent: US2012/101099, 2012, A1. Location in patent: Page/Page column 13; 14
4-Bromo-2-fluorobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-2-fluorobenzaldehyde manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 4-Bromo-2-fluorobenzaldehyde 57848-46-1
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-03
LY Global chemicals co.,ltd .
- Product
- 4-Bromo-2-fluorobenzaldehyde 57848-46-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%Min
- Supply Ability
- 1000kg
- Release date
- 2023-03-13
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 4-Bromo-2-fluorobenzaldehyde 57848-46-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
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