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4-Formyl-2-methylthiazole

Product Name
4-Formyl-2-methylthiazole
CAS No.
20949-84-2
Chemical Name
4-Formyl-2-methylthiazole
Synonyms
IFLAB-BB F2124-0689;4-FORMYL-2-METHYLTHIAZOLE;2-Methyl-4-forMylthiazole;4-Formyl-2-methyl-1,3-thiazole;2-Methyl-4-thiazolecarbaldehyde;2-Methylthiazole-4-carboxaldehyde;2-Methyl-4-thiazolecarboxaldehyde;4-THIAZOLECARBOXALDEHYDE, 2-METHYL-;2-METHYL-1,3-THIAZOLE-4-CARBALDEHYDE;2-Methyl-1,3-thiazole-4-carboxaldehyde
CBNumber
CB3378469
Molecular Formula
C5H5NOS
Formula Weight
127.16
MOL File
20949-84-2.mol
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4-Formyl-2-methylthiazole Property

Melting point:
56-58
Boiling point:
219.0±13.0 °C(Predicted)
Density 
1.270±0.06 g/cm3(Predicted)
Flash point:
110℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
1.22±0.10(Predicted)
Appearance
Off-white to yellow Solid
InChI
InChI=1S/C5H5NOS/c1-4-6-5(2-7)3-8-4/h2-3H,1H3
InChIKey
AEHWVNPVEUVPMT-UHFFFAOYSA-N
SMILES
S1C=C(C=O)N=C1C
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
Hazard Note 
Harmful
HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
717231
Product name
2-Methylthiazole-4-carboxaldehyde
Purity
97%
Packaging
500mg
Price
$124
Updated
2023/06/20
TRC
Product number
F701245
Product name
4-Formyl-2-methylthiazole
Packaging
250mg
Price
$70
Updated
2021/12/16
Apolloscientific
Product number
OR5201
Product name
2-Methyl-1,3-thiazole-4-carboxaldehyde
Purity
97%
Packaging
250mg
Price
$25
Updated
2021/12/16
Matrix Scientific
Product number
069422
Product name
4-Formyl-2-methylthiazole
Purity
96%
Packaging
5g
Price
$438
Updated
2021/12/16
Matrix Scientific
Product number
069422
Product name
4-Formyl-2-methylthiazole
Purity
96%
Packaging
1g
Price
$145
Updated
2021/12/16
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4-Formyl-2-methylthiazole Chemical Properties,Usage,Production

Chemical Properties

Yellow Powder

Synthesis

6436-59-5

20949-84-2

The general procedure for the synthesis of 2-methyl-4-thiazolecarboxaldehyde using ethyl 2-methylthiazole-4-carboxylate as starting material was as follows: to a solution of ethyl 2-methylthiazole-4-carboxylate (1.00 g, 5.8 mmol) in toluene (18 mL) was slowly added dropwise to a solution of diisobutylaluminum hydroxide in dichloromethane (11.1 mL, 1 M) at -78 °C. After the dropwise addition was completed, the reaction system was kept at -78 °C and stirring was continued for 4 hours. Subsequently, the reaction was quenched by the addition of acetic acid (0.46 mL) and concentrated by slowly warming the reaction mixture to 25 °C. The concentrated residue was treated with dichloromethane and Rochelle's salt with vigorous stirring until a clarified two-phase solution was formed (about 10 min). The organic and aqueous layers were separated, and the organic layer was washed sequentially with 10% NaHCO3 solution and saturated saline, then dried with anhydrous Na2SO4, filtered and concentrated. Finally, the residue was purified by silica gel column chromatography, using 14% ethyl acetate in hexane solution as eluent, to obtain the target product 2-methyl-4-thiazolecarboxaldehyde (0.28 g, 38% yield).

References

[1] Organic Letters, 2008, vol. 10, # 8, p. 1565 - 1568
[2] Angewandte Chemie - International Edition in English, 1997, vol. 36, # 1-2, p. 166 - 168
[3] Journal of the American Chemical Society, 1997, vol. 119, # 34, p. 7974 - 7991
[4] Organic Letters, 2012, vol. 14, # 24, p. 6354 - 6357
[5] Angewandte Chemie - International Edition, 2000, vol. 39, # 1, p. 209 - 213

4-Formyl-2-methylthiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Formyl-2-methylthiazole Suppliers

Belgium 1 Canada 1 China 116 Germany 3 India 2 Ukraine 2 United Kingdom 4 United States 18 Global 147
UkrOrgSynthesis Ltd.
Tel
--
Fax
--
Email
y.barysheva@ukrorgsynth.com
Country
Ukraine
ProdList
6230
Advantage
38
Enamine
Tel
--
Fax
--
Email
enamine@enamine.net
Country
Ukraine
ProdList
6216
Advantage
67
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View Lastest Price from 4-Formyl-2-methylthiazole manufacturers

Career Henan Chemical Co
Product
4-FORMYL-2-METHYLTHIAZOLE 20949-84-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

20949-84-2, 4-Formyl-2-methylthiazoleRelated Search:

2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID 2-PHENYL-1,3-THIAZOLE-4-CARBOXYLIC ACID ETHYL 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLATE THIOSTREPTON 1-(2-PHENYL-1,3-THIAZOL-4-YL)ETHAN-1-ONE 4-METHYL-1,3-THIAZOLE-2-CARBALDEHYDE 5-FORMYL-4-METHYLTHIAZOLE 2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBALDEHYDE Thiazole-4-carboxaldehyde 1-(2-[(2-PYRIDYLSULFONYL)METHYL]-1,3-THIAZOL-4-YL)ETHAN-1-ONE ETHYL 2-[(4,5-DICHLORO-1H-IMIDAZOL-1-YL)METHYL]-1,3-THIAZOLE-4-CARBOXYLATE 2-(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)-1,3-THIAZOLE-4-CARBOXYLIC ACID, 90%+ 2-PYRIDIN-3-YL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER ETHYL 2-(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)-1,3-THIAZOLE-4-CARBOXYLATE 2-PHENYL-1,3-THIAZOLE-4,5-DICARBOXYLIC ACID DIETHYL ESTER ETHYL 2-(2,3-DICHLOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLATE 5-methyl-1,3-thiazole-2-carbaldehyde 2-METHYL-1,3-THIAZOLE-5-CARBALDEHYDE

  • IFLAB-BB F2124-0689
  • 4-FORMYL-2-METHYLTHIAZOLE
  • 4-THIAZOLECARBOXALDEHYDE, 2-METHYL-
  • 2-Methyl-1,3-thiazole-4-carboxaldehyde
  • 2-Methyl-1,3-thiazole-4-carboxaldehyde 97%
  • 4-Formyl-2-methyl-1,3-thiazole
  • 2-METHYL-1,3-THIAZOLE-4-CARBALDEHYDE
  • 2-Methyl-4-thiazolecarboxaldehyde
  • 2-Methylthiazole-4-carboxaldehyde
  • 2-Methyl-4-forMylthiazole
  • 2-<WBR>Methylthiazole-<WBR>4-<WBR>carboxaldehyde
  • 2-Methyl-4-thiazolecarbaldehyde
  • 2-Methyl-1,3-thiazole-4-carboxaldehyde97%
  • 20949-84-2
  • Building Blocks
  • Thiazole