Alendronic acid

Product Name: Alendronic acid
CAS No.: 66376-36-1
Chemical Name: Alendronic acid
Synonyms: ALENDRONATE;Bisphosphonate;Alendronate Sodium Hydrate;ABDP;R3-RM2;Onclast;Aledronate;alendronicaci;ALENDRONIC ACID;Alendronic Acid >
CBNumber: CB3380835
Molecular Formula: C4H13NO7P2
Formula Weight: 249.1
MOL File: 66376-36-1.mol

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Alendronic acid Property

Melting point:: 230-235°C
Boiling point:: 616.7±65.0 °C(Predicted)
Density: 1.857±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
Water Solubility: Insoluble in water
solubility: Aqueous Base (Sparingly), Methanol (Slightly), Water (Very Slightly)
form: powder to crystal
pka: pK1 2.72 ±0.05; pK2 8.73 ±0.05; pK3 10.5 ±0.1; pK4 11.6 ±0.1 at 25°, (0.1M KCl)
color: White to Light yellow
Merck: 14,229
Stability:: Hygroscopic
EPA Substance Registry System: Phosphonic acid, P,P'-(4-amino-1-hydroxybutylidene)bis- (66376-36-1)

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Safety

RIDADR: 1759
RTECS: SZ6521833
HS Code: 2931.90.9051
HazardClass: 8
PackingGroup: III
Hazardous Substances Data: 66376-36-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2120
Product name: Alendronic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $67
Updated: 2024/03/01

TCI Chemical

Product number: A2120
Product name: Alendronic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $199
Updated: 2024/03/01

Matrix Scientific

Product number: 099914
Product name: (4-Amino-1-hydroxybutane-1,1-diyl)diphosphonic acid
Purity: 95+%
Packaging: 5g
Price: $49
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA38407
Product name: Alendronic acid
Packaging: 25g
Price: $60
Updated: 2021/12/16

Chem-Impex

Product number: 37567
Product name: Alendronicacid,98%(Assaybytitration)
Purity: 98%(Assaybytitration)
Packaging: 5G
Price: $62.72
Updated: 2021/12/16

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Alendronic acid Chemical Properties,Usage,Production

Originator

Adronat ,Neopharmed ,Italy

Uses

Alendronate acid is an inhibitor of FDPS.

Definition

ChEBI: A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.

Manufacturing Process

4-Amino-1-hydroxybutylidene-1,1-diphosphonic acid (ABDT).
Orthosphophorous acid (102.7 g; 1.25 moles) is introduced into a 2 liter-flask with condenser, stirrer and dropping funnel, placed on a thermostatized bath; the air is then removed with a nitrogen stream which is continued during all the reaction. The acid is melted by heating the bath to 95°C. When melting is complete, 4-aminobutyric acid (103.3; 1 mole) is added under stirring which is continued till obtaining a doughy fluid. Phosphorous trihalide (176 ml; 2 moles) is added dropwise causing the mixture to boil and evolution of gaseous hydrochloric acid which is damped by means of a suitable trap. The addition rate is adjusted so as to keep a constant reflux for about 60 minutes. When the addition is nearly over, the mixture swells, slowly hardening. Stirring is continued as long as possible, whereafter the mixture is heated for further 3 hours. Without cooling, but removing the bath, water (300 ml) is added, first slowly and then quickly. Heating and stirring are started again. Decolorizing charcoal is added and the mixture is boiled for about 5 minutes, then hotfiltered on paper and the filtrate is refluxed for 6 hours. After cooling is slowly poured in stirred methanol (1500 ml) causing thereby the separation of a white solid which collected and dried (161 g; 64.6%). The structure of ABDT is confirmed by IR spectrum, proton magnetic and nuclear magnetic resonance spectrum and elemental analysis.
The sodium salt of this acid may be prepared by adding of equivalent of sodium hydroxide.

Therapeutic Function

Antiosteoporotic

Hazard

A reproductive hazard.

Clinical Use

Bisphosphonate:
Treatment and prophylaxis of osteoporosis

Drug interactions

Potentially hazardous interactions with other drugs
Calcium salts: reduced absorption of alendronate.

Metabolism

Alendronate transiently distributes to soft tissues but is then rapidly redistributed to bone or excreted in the urine. There is no evidence that alendronate is metabolised in animals or humans. Following a single intravenous dose of [14C]-alendronate, approximately 50% of the radioactivity was excreted in the urine within 72 hours and little or no radioactivity was recovered in the faeces.

Alendronic acid Preparation Products And Raw materials

Raw materials

4-Aminobutyric acid Phosphoric acid

Preparation Products

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Alendronic acid Suppliers

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View Lastest Price from Alendronic acid manufacturers

Dideu Industries Group Limited

Product: Alendronic acid 66376-36-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-28

Shaanxi Dideu Medichem Co. Ltd

Product: Alendronic acid 66376-36-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 600 Tons
Release date: 2020-05-03

Career Henan Chemical Co

Product: Alendronic acid 66376-36-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-31

66376-36-1, Alendronic acidRelated Search:

Repaglinide Voglibose Elcatonin Alendronate sodium SMCC crosslinker Phosphonic acid, P,P'-[4-[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]amino]-1-hydroxybutylidene]bis- Alendronic acid Alendronic acid monosodium salt,ALENDRONIC ACID, MONOSODIUM SALT, TRIHYDRATE Alendronic Acid-D6 (Major) N-Trifluoroacetyl Alendronic Acid alendronate，ALD Alendronic Acid-d6 ALENDRONIC ACID DEUTERATED N-T-BOC-GLYCYLALENDRONIC ACID, SODIUM SALT, [ALENDRONATE-4-14C]- GLYCYLALENDRONIC ACID, SODIUM SALT, [ALENDRONATE-4-14C]- ALENDRONATE, SODIUM SALT, [4-14C]-

4-AMINO-1-HYDROXY-1,1-BUTYLIDINEDIPHOSPHONIC ACID

(4-AMINO-1-HYDROXY-1-PHOSPHONOBUTYL)PHOSPHONIC ACID

(4-AMINO-1-HYDROXYBUTYLIDENE)-BIS-(PHOSPHONIC ACID)

(4-AMINO-1-HYDROXYBUTYLIDENE)DIPHOSPHONIC ACID

ALENDRONATE

ALENDRONIC ACID

(4-amino-1-hydroxybutylidene)bis-phosphonicaci

4-amino-1-hydroxybutylidene-1,1-bis(phosphonicacid)

4-Amino-1-hydroxybutane-1,1-diphosphonic Acid

ABDP

Onclast

AlendronateSodium/AlendronicAcid

1-Hydroxy-4-aminobutylidenebisphosphonic acid

4-Amino-1-hydroxy-1,1-butanediylbisphosphonic acid

4-Amino-1-hydroxybutane-1,1-diylbis(phosphonic acid)

Bisphosphonate

Alendronate Sodium Hydrate

Aledronate

Phosphonic acid, (4-aMino-1-hydroxybutylidene)bis-

(4-aMino-1-hydroxybutane-1,1-diyl)diphosphonic acid

Phosphonic acid,P,P'-(4-aMino-1-hydroxybutylidene)bis-

Alendronic Acid &gt

alendronicaci

Alendronic acid USP/EP/BP

R3-RM2

Alendronic AcidQ: What is Alendronic Acid Q: What is the CAS Number of Alendronic Acid Q: What is the storage condition of Alendronic Acid Q: What are the applications of Alendronic Acid

(4-amino-1-hydroxybutylidene)bis- phosphonic aci 4-amino-1-hydroxybutylidene- 1,1-bis(phosphonic acid) alendronate alendronic acid

66376-36-1

66736-36-1

C4H13NO7P2

Miscellaneous Biochemicals

(intermediate of alendronate sodium)