6(5H)-Phenanthridone
- Product Name
- 6(5H)-Phenanthridone
- CAS No.
- 1015-89-0
- Chemical Name
- 6(5H)-Phenanthridone
- Synonyms
- PJ 97A;NSC 11021;NSC 40943;NSC 61083;WD 99-004344;Phenantridone;PHENANTHRIDONE;PHENANTHRIDINONE;6-Phenanthridone;6-Phenanthridinol
- CBNumber
- CB3386736
- Molecular Formula
- C13H9NO
- Formula Weight
- 195.22
- MOL File
- 1015-89-0.mol
6(5H)-Phenanthridone Property
- Melting point:
- 290-292 °C(lit.)
- Boiling point:
- 435 °C
- Density
- 1.230±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMF: 1mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16mg/mL
- pka
- 13.27±0.20(Predicted)
- form
- powder to crystal
- color
- White to Light yellow to Light orange
- Water Solubility
- Soluble in DMSO (5 mg/ml). Insoluble in water.
- λmax
- 338nm(EtOH)(lit.)
- BRN
- 140641
- CAS DataBase Reference
- 1015-89-0(CAS DataBase Reference)
- NIST Chemistry Reference
- 6(5H)-phenanthridinone(1015-89-0)
- EPA Substance Registry System
- 6-Phenanthridinone (1015-89-0)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- SG0370000
- HS Code
- 29337900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 299634
- Product name
- 6-(5H)-Phenanthridinone
- Purity
- technical grade
- Packaging
- 1g
- Price
- $25.72
- Updated
- 2024/03/01
- Product number
- P1998
- Product name
- 6(5H)-Phenanthridinone
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $34
- Updated
- 2024/03/01
- Product number
- P1998
- Product name
- 6(5H)-Phenanthridinone
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $115
- Updated
- 2024/03/01
- Product number
- B25187
- Product name
- 6(5H)-Phenanthridinone, 96%
- Packaging
- 1g
- Price
- $37.65
- Updated
- 2024/03/01
- Product number
- B25187
- Product name
- 6(5H)-Phenanthridinone, 96%
- Packaging
- 5g
- Price
- $126.65
- Updated
- 2024/03/01
6(5H)-Phenanthridone Chemical Properties,Usage,Production
Uses
6-Phenanthridone is a poly(ADP-ribose) polymerase (PARP) inhibitor with immunosuppressive effects. 6-Phenanthridone has been shown to inhibit concanavalin A-induced lymphocyte proliferation.
Uses
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.
Definition
ChEBI: A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.
Synthesis Reference(s)
Canadian Journal of Chemistry, 35, p. 180, 1957 DOI: 10.1139/v57-027
Journal of the American Chemical Society, 79, p. 1245, 1957 DOI: 10.1021/ja01562a054
General Description
6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.
6(5H)-Phenanthridone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6(5H)-Phenanthridone manufacturers
- Product
- Phenanthridin-6(5H)-one 1015-89-0
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 6(5H)-Phenanthridone 1015-89-0
- Price
- US $44.00-593.00/g
- Min. Order
- 25g
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2023-12-11
- Product
- 6(5H)-Phenanthridone 1015-89-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-10-16