ChemicalBook > CAS DataBase List > 6(5H)-Phenanthridone

6(5H)-Phenanthridone

Product Name
6(5H)-Phenanthridone
CAS No.
1015-89-0
Chemical Name
6(5H)-Phenanthridone
Synonyms
PJ 97A;NSC 11021;NSC 40943;NSC 61083;WD 99-004344;Phenantridone;PHENANTHRIDONE;PHENANTHRIDINONE;6-Phenanthridone;6-Phenanthridinol
CBNumber
CB3386736
Molecular Formula
C13H9NO
Formula Weight
195.22
MOL File
1015-89-0.mol
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6(5H)-Phenanthridone Property

Melting point:
290-292 °C(lit.)
Boiling point:
435 °C
Density 
1.230±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMF: 1mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16mg/mL
pka
13.27±0.20(Predicted)
form 
powder to crystal
color 
White to Light yellow to Light orange
Water Solubility 
Soluble in DMSO (5 mg/ml). Insoluble in water.
λmax
338nm(EtOH)(lit.)
BRN 
140641
CAS DataBase Reference
1015-89-0(CAS DataBase Reference)
NIST Chemistry Reference
6(5H)-phenanthridinone(1015-89-0)
EPA Substance Registry System
6-Phenanthridinone (1015-89-0)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
SG0370000
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
299634
Product name
6-(5H)-Phenanthridinone
Purity
technical grade
Packaging
1g
Price
$25.72
Updated
2024/03/01
TCI Chemical
Product number
P1998
Product name
6(5H)-Phenanthridinone
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
P1998
Product name
6(5H)-Phenanthridinone
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$115
Updated
2024/03/01
Alfa Aesar
Product number
B25187
Product name
6(5H)-Phenanthridinone, 96%
Packaging
1g
Price
$37.65
Updated
2024/03/01
Alfa Aesar
Product number
B25187
Product name
6(5H)-Phenanthridinone, 96%
Packaging
5g
Price
$126.65
Updated
2024/03/01
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6(5H)-Phenanthridone Chemical Properties,Usage,Production

Uses

6-Phenanthridone is a poly(ADP-ribose) polymerase (PARP) inhibitor with immunosuppressive effects. 6-Phenanthridone has been shown to inhibit concanavalin A-induced lymphocyte proliferation.

Uses

6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.

Definition

ChEBI: A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.

Synthesis Reference(s)

Canadian Journal of Chemistry, 35, p. 180, 1957 DOI: 10.1139/v57-027
Journal of the American Chemical Society, 79, p. 1245, 1957 DOI: 10.1021/ja01562a054

General Description

6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.

6(5H)-Phenanthridone Preparation Products And Raw materials

Raw materials

Preparation Products

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6(5H)-Phenanthridone Suppliers

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View Lastest Price from 6(5H)-Phenanthridone manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
6(5H)-Phenanthridone 1015-89-0
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-04
Shanghai UCHEM Inc.
Product
6(5H)-Phenanthridone 1015-89-0
Price
US $44.00-593.00/g
Min. Order
25g
Purity
0.98
Supply Ability
25kg
Release date
2023-12-11
Hebei Chuanghai Biotechnology Co,.LTD
Product
6(5H)-Phenanthridone 1015-89-0
Price
US $10.70/kg
Min. Order
10kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-20

1015-89-0, 6(5H)-PhenanthridoneRelated Search:

2,8-DICHLORO-QUINOLINE-3-CARBALDEHYDE 2-Chloro-5-fluorobenzonitrile N-PHENYLETHYLENEDIAMINE Isoquinoline, 6-chloro- (6CI,9CI) Norethindrone Phenanthridine Fanthridone PJ-34 6(5H)-Phenanthridone ISOMETAMIDIUM N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N DIMETHYLACETAMIDE HYDROCHLORIDE HYDRATE 4H-CYCLOPENTA[LMN]PHENANTHRIDINE 5,9-DIONE 6(5H)-PHENANTHRIDINONE, 1,3,8,9-TETRAMETHOXY- 6(5H)-PHENANTHRIDINONE, 1,3,8,9-TETRAMETHOXY-5-METHYL- 6(5H)-PHENANTHRIDINONE, 8,9-DIMETHOXY- 2,3-DIMETHOXY-12-METHYL-12H-[1,3]DIOXOLO-[4',5':4,5]BENZO[1,2-C]PHENANTHRIDIN-13-ONE 6(5H)-PHENANTHRIDINONE, 3,8,9-TRIMETHOXY- 6(5H)-PHENANTHRIDINONE, 3,8,9-TRIMETHOXY-5-METHYL-

  • PHENANTHRIDINONE
  • PHENANTHRIDONE
  • 6(5H)-Phenantridinone
  • 6-Phenanthridinol
  • 6-Phenanthridone
  • Phenantridone
  • 2H-BENZ[C]ISOQUINOLIN-1-ONE
  • phenanthridin-6(5H)-one
  • 3,7-DIAMINO-2-METHOXYFLUOREN 98%
  • 6(5H)-PHENANTHRIDINONE 97%
  • 6-PHENANTHRIDINONE
  • 5,6-Dihydrophenanthridin-6-one
  • 5,6-Dihydrophenanthridine-6-one
  • Benzo[c]quinoline-6(5H)-one
  • 5H-phenanthridin-6-one
  • NSC 11021
  • NSC 40943
  • NSC 61083
  • PJ 97A
  • WD 99-004344
  • phenantridine-6(5H)-one
  • Phenanthridone (misnomer)
  • 6(5H)-PHENANTHRIDINONE
  • 6(5H)-PHENANTHRIDONE
  • 6-(5H)-Phenanthridinone, 97%+
  • 6(5H)-Phenanthridinone&gt
  • Quetiapine Impurity 56
  • Phenanthridine ketone
  • 1015-89-0
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  • N-Containing
  • Pyrazoles
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