2'-AMINOACETANILIDE
- Product Name
- 2'-AMINOACETANILIDE
- CAS No.
- 34801-09-7
- Chemical Name
- 2'-AMINOACETANILIDE
- Synonyms
- 2-AMinoactanilide;O-AMINOACETANILIDE;2-AMINOACETANILIDE;2'-Acetamidoaniline;2'-Aminoacetanilide;Trametinib Impurity 27;2'-Aminoacetanilide 98%;2'-Aminoacetanilide >2'-Aminoacetanilide ,98%;N-(2-aminophenyl)ethanamide
- CBNumber
- CB3389151
- Molecular Formula
- C8H10N2O
- Formula Weight
- 150.18
- MOL File
- 34801-09-7.mol
2'-AMINOACETANILIDE Property
- Melting point:
- 133-137 °C(lit.)
- Boiling point:
- 271.72°C (rough estimate)
- Density
- 1.1392 (rough estimate)
- refractive index
- 1.6180 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystalline
- pka
- 14.73±0.70(Predicted)
- color
- Light orange to Light red
- Water Solubility
- 107.5g/L(22 ºC)
- InChI
- 1S/C8H10N2O/c1-6(11)10-8-5-3-2-4-7(8)9/h2-5H,9H2,1H3,(H,10,11)
- InChIKey
- MPXAYYWSDIKNTP-UHFFFAOYSA-N
- SMILES
- CC(=O)Nc1ccccc1N
- CAS DataBase Reference
- 34801-09-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 549606
- Product name
- 2′-Aminoacetanilide
- Purity
- 98%
- Packaging
- 5g
- Price
- $68.1
- Updated
- 2022/05/15
- Product number
- 549606
- Product name
- 2′-Aminoacetanilide
- Purity
- 98%
- Packaging
- 25g
- Price
- $223
- Updated
- 2022/05/15
- Product number
- A2426
- Product name
- 2'-Aminoacetanilide
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $70
- Updated
- 2025/07/31
- Product number
- A2426
- Product name
- 2'-Aminoacetanilide
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $249
- Updated
- 2024/03/01
- Product number
- A580013
- Product name
- 2''-Aminoacetanilide
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
2'-AMINOACETANILIDE Chemical Properties,Usage,Production
Chemical Properties
White Powder
Uses
2′-Aminoacetanilide may be used in the preparation of:
- 2-Methylbenzimidazole.
- N-(2-(1,3-Dimethyl-2,4-dioxo-5-phenyl-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)phenyl)-5-methylfuran-2-carboxamide, a potent cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor.
- Azobenzothiazole dyes, N-[2-(6-nitrobenzothiazol-2-ylazo)phenyl]acetamide and N-[2-(benzothiazol-2-ylazo)phenyl]acetamide.
General Description
2′-Aminoacetanilide (2-aminoacetanilide, o-aminoacetanilide) can be prepared by the catalytic hydrogenation of 2-nitroacetanilide using 10%Pd/C (palladium/carbon).
Synthesis
552-32-9
34801-09-7
The general procedure for the synthesis of 2'-aminoacetanilide from 2-nitroacetanilide was as follows: first, 2-nitroacetanilide (1.0 g, 5.6 mmol) was dissolved in ethanol (EtOH) and the solution was purged with nitrogen to remove oxygen. Subsequently, palladium hydroxide (Pd(OH)2, 20% by weight, carbon carrier, 200 mg) was added to the solution as a catalyst. The reaction mixture was shaken under hydrogen (H2, 20 psi) atmosphere for 2 hours. Upon completion of the reaction, it was filtered through a 0.22 μm cellulose acetate membrane (Corning) to remove the catalyst. The filtrate was concentrated under vacuum to afford the white crystalline solid product 2'-aminoacetanilide (800 mg, 96% yield). The structure of the product was confirmed by 1H NMR (300 MHz, d6-DMSO) and LRMS (ES pos.): 1H NMR δ: 9.12 (s, 1H), 7.14 (dd, J = 7.8,1.3 Hz, 1H), 6.88 (dt, J = 7.6,1.5 Hz, 1H), 6.70 (dd, J = 8.0,1.3 Hz, 1H), 6.52 (dt, J = 7.5,1.4 Hz, 1H), 4.85 (br s, 2H), 2.03 (s, 3H); LRMS (ES pos.) m/z = 151 (M + 1).
References
[1] Journal of Organic Chemistry, 2008, vol. 73, # 23, p. 9235 - 9244
[2] Patent: US6667300, 2003, B2. Location in patent: Page column 98
[3] Chemistry - A European Journal, 2015, vol. 21, # 26, p. 9493 - 9504
[4] Russian Journal of Organic Chemistry, 1997, vol. 33, # 11, p. 1676 - 1677
[5] Russian Journal of Organic Chemistry, 1997, vol. 33, # 11, p. 1676 - 1677
2'-AMINOACETANILIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2'-AMINOACETANILIDE manufacturers
- Product
- 2'-AMINOACETANILIDE 34801-09-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11