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SANGUINARINE

Description Sources
Product Name
SANGUINARINE
CAS No.
2447-54-3
Chemical Name
SANGUINARINE
Synonyms
C06162;Sangrovit;SANGUINARIN;SANGUINARINE;Free sanguinarine;PSEUDOCHELERYTHRINE;SANGUINARINE, 40+% BY UV;SANGUINARINE, 98+% BY HPLC;dimethylenedioxybenzphenanthridine;Sanguinarine/Macleaya cordata extract
CBNumber
CB3395590
Molecular Formula
C20H14NO4+
Formula Weight
332.33
MOL File
2447-54-3.mol
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SANGUINARINE Property

Melting point:
205-215°C
Boiling point:
483.53°C (rough estimate)
Density 
1.3463 (rough estimate)
refractive index 
1.5180 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
color 
White
LogP
-0.653 (est)
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Safety

Risk Statements 
25
Safety Statements 
13-45
RIDADR 
1544
Toxicity
LD50 oral in rat: 1660mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FS40153
Product name
Sanguinarine
Packaging
10mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FS40153
Product name
Sanguinarine
Packaging
25mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FS40153
Product name
Sanguinarine
Packaging
50mg
Price
$150
Updated
2021/12/16
ApexBio Technology
Product number
N1338
Product name
Sanguinarine
Packaging
20mg
Price
$150
Updated
2021/12/16
Biorbyt Ltd
Product number
orb594267
Product name
Sanguinarine
Packaging
20mg
Price
$306
Updated
2021/12/16
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SANGUINARINE Chemical Properties,Usage,Production

Description

Sanguinarine, a DNA intercalator extracted from the bloodroot plant of the poppy family, was used by Native Americans for warts and as a blood purifier. In modern use, although banned by the FDA for its association with epidemic dropsy and other toxic effects, it has shown potential as a treatment for cancer, with modes of action including inhibition of metastasis and angiogenesis, and promotion of apoptosis. It also has anti-inflammatory, anti-oxidant, and anti-microbial properties, and several applications in veterinary medicine.

Sources

https://en.wikipedia.org/wiki/Sanguinarine
https://pubchem.ncbi.nlm.nih.gov/compound/sanguinarine#section=Human-Metabolite-Information
https://www.essense-of-life.com/healthtopics/A-513/Sanguinarine-Health-Topic.html
https://www.caymanchem.com/product/16951
https://www.sciencedirect.com/topics/nursing-and-health-professions/sanguinarine

Description

A naphthoisoquinoline alkaloid, this base occurs in the roots of Chelidonium majus L., Glaucium fimbrilligerum and Sanguinaria canadensis L. The alkaloid was stated by Schmidt, Konig and Tietz to crystallize from EtOH or AcOEt as colourless needles, m.p. 213°C but this low melting point was found to be due to the presence of chelerythrine as an impurity. Once this is removed as the pseudocyanide, the base crystallizes from Et20 and has the above melting point or 242-3°C on slow heating. Obtained from EtOH it forms the alcoholate, m.p. 195-7°C. The hydrochloride forms long, slender, bloodred needles. On distillation with Zn dust, the alkaloid furnishes a-naphthaphenanthridine and the structure given above has been further confirmed by synthesis.

Uses

Sanguinarium induces HO-1 expression thus inhibiting MMP-9 and COX-2 expression in TPA-induced breast cancer cells.

Definition

Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadendid. Limited available evidence indicates that it may be used to prevent and treat UV-induced skin damage. Specifically, topical application of sanguinarine on the skin of SKH-1 hairless mice before or after UVB irradiation resulted in significantly lower UVB-mediated skin edema, skin hyperplasia and infiltration of leukocytes, and markers of oxidative stress (e.g., H2O2).

References

Dana., Mag. Pharm., 23, 125 (1829)
Bruchhausen, Bersch., Ber., 63, 2520 (1930)
Spath, Kuffner., ibid, 64, 370, 1123, 2034 (1931)
Synthesis:
Dyke, Moon, Sainsbury., Tetrahedron Lett., 3933 (1968)

SANGUINARINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SANGUINARINE manufacturers

Shanghai Affida new material science and technology center
Product
Sanguinarine 2447-54-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000 tons
Release date
2024-04-16
Shaanxi Haibo Biotechnology Co., Ltd
Product
Plumepoppy Extract 2447-54-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-08
Shanghai Standard Technology Co., Ltd.
Product
Sanguinarine 2447-54-3
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC
Supply Ability
100 g
Release date
2020-08-18

2447-54-3, SANGUINARINERelated Search:

JATRORRHIZINE HCL(RG) Coptisine chloride CUCURBITACIN IIA Berberine Ferulic Acid Celastrus angulatus Spatholobi Caulis Capillary Wormwood Herb Extract Sanguinarine citrate chelerythrine chloride-sanguinarine chloride mixt. SANGUINARINE HCl hplc,SANGUINARINE(SH),SANGUINARINE CHLORIDE,SANGUINARINE HCL SANGUINARINE CHLORIDE(RG) Ethoxysanguinarine DIHYDROSANGUINARINE(P) SANGUINARINE NITRATE,SANGUINARINE NITRATE(RG) SANGUINARINE CHLORIDE HYDRATE SANGUINARINE SULFATE SANGUINARINE HCL DIHYDRATE

  • 13-Methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium
  • C06162
  • PSEUDOCHELERYTHRINE
  • SANGUINARIN
  • SANGUINARINE
  • 3)-benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium,13-methyl-(
  • dimethylenedioxybenzphenanthridine
  • SANGUINARINE CHLORIDE ISOLATED FROM MACL EAY
  • SANGUINARINE, 98+% BY HPLC
  • SANGUINARINE, 40+% BY UV
  • Sangrovit
  • Sanguinarine/Macleaya cordata extract
  • Sanguinarium DISCONTINUED. Please see S112500.
  • 13-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium
  • Free sanguinarine
  • 2447-54-3
  • C20H14NO4
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Inhibitors
  • natural product
  • Alkaloids