SANGUINARINE

ChemicalBook > CAS DataBase List > SANGUINARINE

Description Sources

Product Name: SANGUINARINE
CAS No.: 2447-54-3
Chemical Name: SANGUINARINE
Synonyms: C06162;Sangrovit;SANGUINARIN;SANGUINARINE;Free sanguinarine;PSEUDOCHELERYTHRINE;SANGUINARINE, 40+% BY UV;SANGUINARINE, 98+% BY HPLC;Sanguinarin|||Pseudochelerythrine;dimethylenedioxybenzphenanthridine
CBNumber: CB3395590
Molecular Formula: C20H14NO4
Formula Weight: 332.33
MOL File: 2447-54-3.mol

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SANGUINARINE Property

Melting point:: 205-215°C
Boiling point:: 483.53°C (rough estimate)
Density: 1.3463 (rough estimate)
refractive index: 1.5180 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly)
form: Solid
color: White
LogP: -0.653 (est)

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Safety

Risk Statements: 25
Safety Statements: 13-45
RIDADR: 1544
Toxicity: LD50 oral in rat: 1660mg/kg

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FS40153
Product name: Sanguinarine
Packaging: 10mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS40153
Product name: Sanguinarine
Packaging: 25mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS40153
Product name: Sanguinarine
Packaging: 50mg
Price: $150
Updated: 2021/12/16

ApexBio Technology

Product number: N1338
Product name: Sanguinarine
Packaging: 20mg
Price: $150
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594267
Product name: Sanguinarine
Packaging: 20mg
Price: $306
Updated: 2021/12/16

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SANGUINARINE Chemical Properties,Usage,Production

Description

Sanguinarine, a DNA intercalator extracted from the bloodroot plant of the poppy family, was used by Native Americans for warts and as a blood purifier. In modern use, although banned by the FDA for its association with epidemic dropsy and other toxic effects, it has shown potential as a treatment for cancer, with modes of action including inhibition of metastasis and angiogenesis, and promotion of apoptosis. It also has anti-inflammatory, anti-oxidant, and anti-microbial properties, and several applications in veterinary medicine.

Sources

https://en.wikipedia.org/wiki/Sanguinarine
https://pubchem.ncbi.nlm.nih.gov/compound/sanguinarine#section=Human-Metabolite-Information
https://www.essense-of-life.com/healthtopics/A-513/Sanguinarine-Health-Topic.html
https://www.caymanchem.com/product/16951
https://www.sciencedirect.com/topics/nursing-and-health-professions/sanguinarine

Description

A naphthoisoquinoline alkaloid, this base occurs in the roots of Chelidonium majus L., Glaucium fimbrilligerum and Sanguinaria canadensis L. The alkaloid was stated by Schmidt, Konig and Tietz to crystallize from EtOH or AcOEt as colourless needles, m.p. 213°C but this low melting point was found to be due to the presence of chelerythrine as an impurity. Once this is removed as the pseudocyanide, the base crystallizes from Et₂0 and has the above melting point or 242-3°C on slow heating. Obtained from EtOH it forms the alcoholate, m.p. 195-7°C. The hydrochloride forms long, slender, bloodred needles. On distillation with Zn dust, the alkaloid furnishes a-naphthaphenanthridine and the structure given above has been further confirmed by synthesis.

Uses

Sanguinarium induces HO-1 expression thus inhibiting MMP-9 and COX-2 expression in TPA-induced breast cancer cells.

Definition

Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadendid. Limited available evidence indicates that it may be used to prevent and treat UV-induced skin damage. Specifically, topical application of sanguinarine on the skin of SKH-1 hairless mice before or after UVB irradiation resulted in significantly lower UVB-mediated skin edema, skin hyperplasia and infiltration of leukocytes, and markers of oxidative stress (e.g., H2O2).

References

Dana., Mag. Pharm., 23, 125 (1829)
Bruchhausen, Bersch., Ber., 63, 2520 (1930)
Spath, Kuffner., ibid, 64, 370, 1123, 2034 (1931)
Synthesis:
Dyke, Moon, Sainsbury., Tetrahedron Lett., 3933 (1968)

SANGUINARINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SANGUINARINE manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Plumepoppy Extract 2447-54-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-09-08

Shanghai Standard Technology Co., Ltd.

Product: Sanguinarine 2447-54-3
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC
Supply Ability: 100 g
Release date: 2020-08-18

Career Henan Chemical Co

Product: SANGUINARINE 2447-54-3
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1 ton
Release date: 2018-08-20

2447-54-3, SANGUINARINERelated Search:

JATRORRHIZINE HCL(RG) Coptisine chloride CUCURBITACIN IIA Berberine Ferulic Acid Celastrus angulatus Spatholobi Caulis Capillary Wormwood Herb Extract Sanguinarine citrate chelerythrine chloride-sanguinarine chloride mixt. SANGUINARINE HCl hplc,SANGUINARINE(SH),SANGUINARINE CHLORIDE,SANGUINARINE HCL SANGUINARINE CHLORIDE(RG) Ethoxysanguinarine DIHYDROSANGUINARINE(P) SANGUINARINE NITRATE,SANGUINARINE NITRATE(RG) SANGUINARINE CHLORIDE HYDRATE SANGUINARINE SULFATE SANGUINARINE HCL DIHYDRATE

13-Methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium

C06162

PSEUDOCHELERYTHRINE

SANGUINARIN

SANGUINARINE

3)-benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium,13-methyl-(

dimethylenedioxybenzphenanthridine

SANGUINARINE CHLORIDE ISOLATED FROM MACL EAY

SANGUINARINE, 98+% BY HPLC

SANGUINARINE, 40+% BY UV

Sangrovit

Sanguinarine/Macleaya cordata extract

Sanguinarium DISCONTINUED. Please see S112500.

13-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium

Free sanguinarine

Sanguinarin|||Pseudochelerythrine

[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, 13-methyl-

13-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium

2447-54-3

C20H14NO4

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Inhibitors

natural product

Alkaloids