SANGUINARINE CHLORIDE
- Product Name
- SANGUINARINE CHLORIDE
- CAS No.
- 5578-73-4
- Chemical Name
- SANGUINARINE CHLORIDE
- Synonyms
- viadent;Sanguinarium;SANGUINARINE HCL;SANGUINARINE(SH);PSEUDOCHELERYTHRINE;SPECIOCILIATINE(SH);sanguinariumchloride;SANGUINARINE CHLORIDE;SANGUINARINE HCl hplc;Sanguinarine Choloride
- CBNumber
- CB4228826
- Molecular Formula
- C20H14ClNO4
- Formula Weight
- 367.78
- MOL File
- 5578-73-4.mol
SANGUINARINE CHLORIDE Property
- Melting point:
- 281-285°C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- methanol: 20 mg/mL, clear, orange
- form
- Orange solid.
- color
- Orange to Dark Orange
- Stability:
- Hygroscopic, Light Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S5890
- Product name
- Sanguinarine chloride hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- S5890
- Product name
- Sanguinarine chloride hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $685
- Updated
- 2024/03/01
- Product number
- 16951
- Product name
- Sanguinarine (chloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 16951
- Product name
- Sanguinarine (chloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 16951
- Product name
- Sanguinarine (chloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
SANGUINARINE CHLORIDE Chemical Properties,Usage,Production
Uses
Sanguinarium Chloride is a natural product with antimicrobial, anti-inflammatory, and anti-oxidant properties. Sanguinarium Chloride has antiproliferative, pro-apoptosis effects in some cancer cell lines.
Uses
antineoplastic, antiplaque agent
Uses
Sanguinarine chloride hydrate was tested for anti-schistosomal activities against Schistosoma mansoni.9 It was tested for anti-lipase activity against Candida rugosa lipase.10
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
sanguinarine chloride is a potent and specific inhibitor of pp2c with ki value of 0.68 μm, and is also a selective and cell-active inhibitor of mkp-1 with ic50 value of 10 μm. sanguinarine is also an allosteric activator of ampk [1][2][3].protein phosphatase 2c (pp2c) is a serine/threonine-specific phosphatase, the activity of which is dependent on mg2+ or mn2+. pp2c dephosphorylates a number of substrates such as cyclin-dependent kinase, mitogen-activated kinase (mapk) and bad. mitogen-activated protein kinase phosphatase-1 (mkp-1) is a dual specificity phosphatase. amp-activated protein kinase (ampk) plays an important role in the regulation of cellular metabolism [1][2][3].sanguinarine chloride is an inhibitor of pp2c and mkp-1, and also an allosteric activator of ampk with antibiotic and antitumor activity. sanguinarine competed with α-casein to inhibit pp2c and exhibited selectivity for pp2c as compared with pp1, pp2a and pp2b. in human promyelocytic leukemia cell line hl60, sanguinarine exhibited cytotoxicity with ic50 value of 0.37 μm and induced apoptosis via a caspase-3/7-dependent mechanism involving the phosphorylation of p38, a pp2c substrate [1]. sanguinarine inhibited mkp-1 and mkp-l with ic50 values of 17.3 and 12.5 μm. in panc-1 human pancreatic cancer cells, sanguinarine increased erk and jnk/sapk phosphorylation [2]. in the mda mb-231 cell line, sanguinarine caused ampk and the downstream acetyl-coa carboxylase (acc) phosphorylation [3]. in lncap and du145 cells, sanguinarine inhibited cell growth, induced g0/g1 phase arrest and apoptosis [4].
Biochem/physiol Actions
Sanguinarine is a benzophenanthridine alkaloid isolated from plants belonging to the family Papaveracea. It exhibits anti-bacterial, anti-fungal, anti-inflammatory and anti-cancer properties. It induces cell cycle arrest and sensitizes cancer cells to apoptosis by activating TNF-related apoptosis inducing ligand.6,7 It inhibits STAT3, MMP-2, MMP-9, interacts with glutathione, induces generation of ROS, disrupts the microtubule assembly and causes DNA damage resulting the death of the cancer cells.6,7,8
storage
Store at +4°C
References
[1]. aburai n, yoshida m, ohnishi m, et al. sanguinarine as a potent and specific inhibitor of protein phosphatase 2c in vitro and induces apoptosis via phosphorylation of p38 in hl60 cells. biosci biotechnol biochem, 2010, 74(3): 548-552.
[2]. vogt a, tamewitz a, skoko j, et al. the benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1. j biol chem, 2005, 280(19): 19078-19086.
[3]. choi j, he n, sung mk, et al. sanguinarine is an allosteric activator of amp-activated protein kinase. biochem biophys res commun, 2011, 413(2): 259-263.
[4]. adhami vm, aziz mh, reagan-shaw sr, et al. sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. mol cancer ther, 2004, 3(8): 933-940.
SANGUINARINE CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SANGUINARINE CHLORIDE manufacturers
- Product
- Sanguinarine chloride 5578-73-4
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-12-04
- Product
- Sanguinarine Chloride 5578-73-4 5578-73-4
- Price
- US $15.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-17
- Product
- SANGUINARINE CHLORIDE 5578-73-4
- Price
- US $1.00-1.00/kg
- Min. Order
- 1 mg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-25