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SANGUINARINE CHLORIDE

Product Name
SANGUINARINE CHLORIDE
CAS No.
5578-73-4
Chemical Name
SANGUINARINE CHLORIDE
Synonyms
viadent;Sanguinarium;SANGUINARINE HCL;SANGUINARINE(SH);PSEUDOCHELERYTHRINE;SPECIOCILIATINE(SH);sanguinariumchloride;SANGUINARINE CHLORIDE;SANGUINARINE HCl hplc;Sanguinarine Choloride
CBNumber
CB4228826
Molecular Formula
C20H14ClNO4
Formula Weight
367.78
MOL File
5578-73-4.mol
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SANGUINARINE CHLORIDE Property

Melting point:
281-285°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
methanol: 20 mg/mL, clear, orange
form 
Orange solid.
color 
Orange to Dark Orange
Water Solubility 
H2O: slightly soluble <0.3mg/mL
methanol: 3.8mg/mL
Stability:
Hygroscopic, Light Sensitive
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36-26
WGK Germany 
3
RTECS 
VP5220000
F 
10
HS Code 
29399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S5890
Product name
Sanguinarine chloride hydrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$172
Updated
2024/03/01
Sigma-Aldrich
Product number
S5890
Product name
Sanguinarine chloride hydrate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$685
Updated
2024/03/01
Cayman Chemical
Product number
16951
Product name
Sanguinarine (chloride)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16951
Product name
Sanguinarine (chloride)
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
16951
Product name
Sanguinarine (chloride)
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
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SANGUINARINE CHLORIDE Chemical Properties,Usage,Production

Uses

Sanguinarium Chloride is a natural product with antimicrobial, anti-inflammatory, and anti-oxidant properties. Sanguinarium Chloride has antiproliferative, pro-apoptosis effects in some cancer cell lines.

Uses

antineoplastic, antiplaque agent

Uses

Sanguinarine chloride hydrate was tested for anti-schistosomal activities against Schistosoma mansoni.9 It was tested for anti-lipase activity against Candida rugosa lipase.10

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

sanguinarine chloride is a potent and specific inhibitor of pp2c with ki value of 0.68 μm, and is also a selective and cell-active inhibitor of mkp-1 with ic50 value of 10 μm. sanguinarine is also an allosteric activator of ampk [1][2][3].protein phosphatase 2c (pp2c) is a serine/threonine-specific phosphatase, the activity of which is dependent on mg2+ or mn2+. pp2c dephosphorylates a number of substrates such as cyclin-dependent kinase, mitogen-activated kinase (mapk) and bad. mitogen-activated protein kinase phosphatase-1 (mkp-1) is a dual specificity phosphatase. amp-activated protein kinase (ampk) plays an important role in the regulation of cellular metabolism [1][2][3].sanguinarine chloride is an inhibitor of pp2c and mkp-1, and also an allosteric activator of ampk with antibiotic and antitumor activity. sanguinarine competed with α-casein to inhibit pp2c and exhibited selectivity for pp2c as compared with pp1, pp2a and pp2b. in human promyelocytic leukemia cell line hl60, sanguinarine exhibited cytotoxicity with ic50 value of 0.37 μm and induced apoptosis via a caspase-3/7-dependent mechanism involving the phosphorylation of p38, a pp2c substrate [1]. sanguinarine inhibited mkp-1 and mkp-l with ic50 values of 17.3 and 12.5 μm. in panc-1 human pancreatic cancer cells, sanguinarine increased erk and jnk/sapk phosphorylation [2]. in the mda mb-231 cell line, sanguinarine caused ampk and the downstream acetyl-coa carboxylase (acc) phosphorylation [3]. in lncap and du145 cells, sanguinarine inhibited cell growth, induced g0/g1 phase arrest and apoptosis [4].

Biochem/physiol Actions

Sanguinarine is a benzophenanthridine alkaloid isolated from plants belonging to the family Papaveracea. It exhibits anti-bacterial, anti-fungal, anti-inflammatory and anti-cancer properties. It induces cell cycle arrest and sensitizes cancer cells to apoptosis by activating TNF-related apoptosis inducing ligand.6,7 It inhibits STAT3, MMP-2, MMP-9, interacts with glutathione, induces generation of ROS, disrupts the microtubule assembly and causes DNA damage resulting the death of the cancer cells.6,7,8

storage

Store at +4°C

References

[1]. aburai n, yoshida m, ohnishi m, et al. sanguinarine as a potent and specific inhibitor of protein phosphatase 2c in vitro and induces apoptosis via phosphorylation of p38 in hl60 cells. biosci biotechnol biochem, 2010, 74(3): 548-552.
[2]. vogt a, tamewitz a, skoko j, et al. the benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1. j biol chem, 2005, 280(19): 19078-19086.
[3]. choi j, he n, sung mk, et al. sanguinarine is an allosteric activator of amp-activated protein kinase. biochem biophys res commun, 2011, 413(2): 259-263.
[4]. adhami vm, aziz mh, reagan-shaw sr, et al. sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. mol cancer ther, 2004, 3(8): 933-940.

SANGUINARINE CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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SANGUINARINE CHLORIDE Suppliers

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View Lastest Price from SANGUINARINE CHLORIDE manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Sanguinarine chloride 5578-73-4
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-12-04
NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Sanguinarine Chloride 5578-73-4 5578-73-4
Price
US $15.00/mg
Min. Order
20mg
Purity
≥98%
Supply Ability
1000.00 kgs
Release date
2019-07-17
Career Henan Chemical Co
Product
SANGUINARINE CHLORIDE 5578-73-4
Price
US $1.00/kg
Min. Order
1 mg
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

5578-73-4, SANGUINARINE CHLORIDERelated Search:

SANGUINARINE CHLORIDE(RG) DIHYDROSANGUINARINE(P) SANGUINARINE CHLORIDE ISOLATED FROM MACL EAY SANGUINARINE NITRATE 1-Methylpyridinium chloride 7-Hydroxyisoquinoline 2-Methoxynaphthalene quinoline,hydrochloride 2,3-Dihydroxynaphthalene 8-Isoquinolinol SANGUINARINE CHLORIDE 7-METHOXY-ISOQUINOLINE 8-Methoxyisoquinoline 7,8-BENZOQUINOLINE Isoquinoline Phenanthridine Sanguinarine citrate Ethoxysanguinarine

  • SANGUINARINE CHLORIDE
  • SANGUINARINE HCL
  • PSEUDOCHELERYTHRINE
  • PSEUDOCHELERYTHRINE CHLORIDE
  • 13-METHYL-[1,3]BENZODIOXOLO[5,6-C]-1,3-DIOXOLO[4,5-I] PHENANTHRIDINIUM CHLORIDE
  • Sanguinarine chloride, froM Macleaya cordata
  • [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium,13-methyl-, chloride (1:1)
  • 3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium,13-methyl-(chlo
  • sanguinarinehydrochloride
  • sanguinariumchloride
  • Sanguinarine chloride hydrate, ≥98%(HPLC)
  • Sanguinarine Chloride 5578-73-4
  • Sanguinarine chloride, 98%, from Macleaya cordata
  • viadent
  • SANGUINARIN-CHLORID 97%
  • Sanguinarium
  • SANGUINARINE(SH)
  • SANGUINARINE HCl hplc
  • SPECIOCILIATINE(SH)
  • Sanguinarine chloride, 98%, from Macleaya cordata (Willd.) R. Br.
  • 13-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium chloride
  • Sanguinarine Choloride
  • Sanguinarine Chloride(AS)
  • Sanguinarine chloride-RM
  • Sanguinarine chloride, PP2C inhibitor
  • Sanguinarine chloride, 10 mM in DMSO
  • 5578-73-4
  • C20H14ClNO4
  • C20H14NO4Cl
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