2-Methoxypyridine
- Product Name
- 2-Methoxypyridine
- CAS No.
- 1628-89-3
- Chemical Name
- 2-Methoxypyridine
- Synonyms
- 2-METHOXYPYRIDINE;2-Methoxyl pyridine;2-Methoxypyridine>2-Methoxypyridine98%;2-Methoxypyridine 99%;2-Pyridol methyl ether;METHYL 2-PYRIDYL ETHER;Methyl pyridin-2-yl ether;2-METHOXY PYRIDINE FEMA NO.--------;2-Methoxypyridine ISO 9001：2015 REACH
- CBNumber
- CB3396719
- Molecular Formula
- C6H7NO
- Formula Weight
- 109.13
- MOL File
- 1628-89-3.mol
2-Methoxypyridine Property
- Boiling point:
- 142 °C (lit.)
- Density
- 1.038 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.503(lit.)
- FEMA
- 4639 | 2-METHOXYPYRIDINE
- Flash point:
- 90 °F
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Liquid
- pka
- 3.28(at 20℃)
- color
- Clear colorless to slightly yellow
- Odor
- at 0.10?%?in?propylene glycol. green fermented tea
- Appearance
- Colorless to Light yellow clear liquid
- Water Solubility
- INSOLUBLE
- JECFA Number
- 2156
- BRN
- 108189
- InChIKey
- IWTFOFMTUOBLHG-UHFFFAOYSA-N
- LogP
- 1.32
- CAS DataBase Reference
- 1628-89-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyridine, 2-methoxy-(1628-89-3)
Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 10-36/37/38
- Safety Statements
- 26-36-16
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- W463901
- Product name
- 2-Methoxypyridine
- Purity
- ≥98%
- Packaging
- 100G
- Price
- $109
- Updated
- 2025/07/31
- Product number
- W463901
- Product name
- 2-Methoxypyridine
- Purity
- ≥98%
- Packaging
- 1 unit
- Price
- $174
- Updated
- 2025/07/31
- Product number
- W463901
- Product name
- 2-Methoxypyridine
- Purity
- ≥98%
- Packaging
- 1 unit
- Price
- $174
- Updated
- 2025/07/31
- Product number
- W463901
- Product name
- 2-Methoxypyridine
- Purity
- ≥98%
- Packaging
- 1KG
- Price
- $428
- Updated
- 2025/07/31
- Product number
- M25406
- Product name
- 2-Methoxypyridine
- Purity
- 98%
- Packaging
- 25g
- Price
- $41.9
- Updated
- 2025/07/31
2-Methoxypyridine Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to slightly yellow liquid
Uses
2-Methoxypyridine can be used as an intermediate to synthesize 2-methoxy-3-pyridinesulfonyl chloride which is patented as a reactant used to prepare erythromycin macrolide antibiotics as antibacterial and antiprotozoal agents. It can also be used to prepare bicyclic iminopyrimidinones as Beta Amyloid Cleaving Enzyme-1 (BACE1) inhibitors.
Synthesis
CsSO4F may be used to fluorinate pyridine directly, but the reaction is very sensitive to the solvents employed. When solvents such as pentane and diethyl ether were used, 2-fluoropyridine was the major product, but use of nucleophilic solvents, such as methanol gave 2-methoxypyridine.
References
[1] DAI W, LIU S, ZHANG Z, et al. Conformational preferences and isomerization upon excitation/ionization of 2-methoxypyridine and 2-N-methylaminopyridine†[J]. Physical Chemistry Chemical Physics, 2018, 9: 6211-6226. DOI:10.1039/C7CP07854D.
[2] Singh, Avtar, et al. "Synthesis of C-6 and C-3 substituted chalcogen derivatives of 2-methoxypyridine through lithiation of 2-methoxypyridine: An experimental and quantum chemical study." Inorganica Chimica Acta 432 (2015): 109-114.
[3] Trécourt, F., et al. "Catalyzed metalation applied to 2-methoxypyridine." The Journal of Organic Chemistry 53.7 (1988): 1367-1371.
[4] Ahipa, T. N., and Airody Vasudeva Adhikari. "2-Methoxypyridine derivatives: synthesis, liquid crystalline and photo-physical properties." New Journal of Chemistry 38.10 (2014): 5018-5029.
[5] WANYING CHENG . Conformation and bonding of 2-methoxypyridine and its monohydrate from rotational spectra[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 239: Article 118434. DOI:10.1016/j.saa.2020.118434.
2-Methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Methoxypyridine Suppliers
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View Lastest Price from 2-Methoxypyridine manufacturers
- Product
- 2-Methoxypyridine 1628-89-3
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2025-09-09
- Product
- 2-methoxypyridine 1628-89-3
- Price
- US $0.00/gm
- Min. Order
- 100gm
- Purity
- 99%min
- Supply Ability
- 100kgs
- Release date
- 2024-09-04
- Product
- 2-Methoxypyridine 1628-89-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10ton
- Release date
- 2024-07-17