3-Fluoro-4-methylbenzonitrile
- Product Name
- 3-Fluoro-4-methylbenzonitrile
- CAS No.
- 170572-49-3
- Chemical Name
- 3-Fluoro-4-methylbenzonitrile
- Synonyms
- 3-Fluoro-4-methylben;3-FLUORO-P-TOLUNITRILE;4-CYANO-2-FLUOROTOLUENE;2-Fluoro-4-cyanotoluene;3-Fluoro-p-tolunitrile>Fluoro-4-methylbenzonitrile;3-Fluoro-p-tolunitrile (CN=1);3-FLUORO-4-METHYLBENZONITRILE;4-METHYL-3-FLUOROBENZONITRILE;4-Cyano-2-fluoro-1-methylbenzene
- CBNumber
- CB3402607
- Molecular Formula
- C8H6FN
- Formula Weight
- 135.14
- MOL File
- 170572-49-3.mol
3-Fluoro-4-methylbenzonitrile Property
- Melting point:
- 47-51 °C
- Boiling point:
- 204°C
- Density
- 1.11±0.1 g/cm3(Predicted)
- Flash point:
- 182 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Orange to Green
- BRN
- 7700177
- InChI
- InChI=1S/C8H6FN/c1-6-2-3-7(5-10)4-8(6)9/h2-4H,1H3
- InChIKey
- KUQQONVKIURIQU-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(C)C(F)=C1
- CAS DataBase Reference
- 170572-49-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 664030
- Product name
- 3-Fluoro-4-methylbenzonitrile
- Purity
- 97%
- Packaging
- 25g
- Price
- $108.5
- Updated
- 2025/07/31
- Product number
- 664030
- Product name
- 3-Fluoro-4-methylbenzonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $51.6
- Updated
- 2023/06/20
- Product number
- F0424
- Product name
- 3-Fluoro-p-tolunitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $49
- Updated
- 2025/07/31
- Product number
- F597788
- Product name
- 3-Fluoro-4-methylbenzonitrile
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-W002443
- Product name
- 3-Fluoro-4-methylbenzonitrile
- Packaging
- 100g
- Price
- $90
- Updated
- 2021/12/16
3-Fluoro-4-methylbenzonitrile Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
3-Fluoro-4-methylbenzonitrile is a nitrile derivative that can be used as a pharmaceutical intermediate.
Synthesis
942282-44-2
170572-49-3
General procedure for the synthesis of 3-fluoro-4-methylbenzonitrile from methyl 2-(4-cyano-2-fluorophenyl)acetate: 1.0 g of methyl 2-(4-cyano-2-fluorophenyl)acetate was added to a 50 mL four-necked flask, followed by the addition of 0.19 g of water, 1.15 g of 95% anhydrous calcium chloride and 15 g of N,N-dimethylacetamide. The mixture was stirred and heated to 140°C to 145°C and the reaction was carried out for 20 to 24 hours (the progress of the reaction was monitored by HPLC to ensure >99% conversion). Upon completion of the reaction, the mixture was cooled to 60°C to 70°C and subsequently concentrated under reduced pressure. Finally, the product was purified by column chromatography to afford 0.62 g of 3-fluoro-4-methylbenzonitrile as a light yellow solid in 89.0% yield.
References
[1] Patent: CN107673994, 2018, A. Location in patent: Paragraph 0063; 0064; 0065
3-Fluoro-4-methylbenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
3-Fluoro-4-methylbenzonitrile Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 3-Fluoro-4-methylbenzonitrile manufacturers
- Product
- 3-Fluoro-4-methylbenzonitrile 170572-49-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-13
- Product
- 3-Fluoro-4-methylbenzonitrile 170572-49-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04