5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL Property

Melting point:

240-242°C

alpha 

D20 +27.4° (c = 0.7 in alc)

Boiling point:

399.39°C (rough estimate)

Density 

1.1500

refractive index 

27 ° (C=0.5, EtOH)

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)

form 

Solid

pka

15.05±0.20(Predicted)

color 

White to Off-White

Merck 

7727

Safety

RTECS 

TU4157113

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Progesterone metabolite

Uses

5β-Pregnane-3α,20α-diol is a metabolite of Progesterone (P755900).

Uses

Labelled 5β-Pregnane-3α,20α-diol, a metabolite of Progesterone (P755900).

Definition

ChEBI: Pregnanediol is a corticosteroid hormone. It is a tautomer of a 5beta-pregnane-3beta,20alpha-diol.

Purification Methods

Crystallise the diol from acetone. The diacetate [1174-69-2] crystallises from pet ether with m 180o (also 182183o) and [] D 20 +35o (c 1.1, CHCl3). [Marian Biochem J 23 1090 1929, Fish et al. J Biol Chem 143 716 1942, Hieschmann J Biol Chem 140 797 1941, Johnson et al. J Chem Soc 1302 1954, Glick et al. J Org Chem 27 3121 1962, Beillstein 6 III 4778, 6 IV 6111.]