ChemicalBook > CAS DataBase List > Periodic acid

Periodic acid

Product Name
Periodic acid
CAS No.
10450-60-9
Chemical Name
Periodic acid
Synonyms
ORTHOPERIODIC ACID;Periodate;periodic;Periodic acid, ACS, 99.01-101.0%;PERIODIC ACI;Periodic acid;PeriodicAcide;PeriodicAcidGr;PeriodicAcid50%;Periodic Acid, ACS
CBNumber
CB3405103
Molecular Formula
H5IO6
Formula Weight
227.94057
MOL File
10450-60-9.mol
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Periodic acid Property

Melting point:
122 °C (lit.)
Boiling point:
140°C
Density 
d417 1.3875; d 1.42
bulk density
1400kg/m3
vapor pressure 
7.6Pa at 25℃
RTECS 
NN1269700
Flash point:
140°C
storage temp. 
Store at +15°C to +25°C.
solubility 
soluble in Methanol, Water
form 
Solid
color 
White to slightly yellow
PH
1.2 (100g/l, H2O, 20℃)
Water Solubility 
Soluble in water and alcohols.
Sensitive 
Moisture & Light Sensitive
Merck 
14,7171
Stability:
Stable, but strong oxidizer. Contact with combustible material may cause fire. Hygroscopic. Incompatible with organic materials, strong reducing agents.
InChIKey
TWLXDPFBEPBAQB-UHFFFAOYSA-N
CAS DataBase Reference
10450-60-9(CAS DataBase Reference)
EPA Substance Registry System
Periodic acid (H5IO6) (10450-60-9)
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Safety

Hazard Codes 
C,O
Risk Statements 
8-34
Safety Statements 
26-27-36/37/39-45-17-36
RIDADR 
UN 3264 8/PG 2
WGK Germany 
3
F 
3-8
TSCA 
Yes
HS Code 
2811 19 80
HazardClass 
5.1
PackingGroup 
II
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H271May cause fire or explosion; strong oxidiser

H314Causes severe skin burns and eye damage

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.22288
Product name
Periodic acid
Purity
for synthesis
Packaging
100g
Price
$149
Updated
2025/07/31
Sigma-Aldrich
Product number
8.22288
Product name
Periodic acid
Purity
for synthesis
Packaging
500g
Price
$438
Updated
2025/07/31
Sigma-Aldrich
Product number
375810
Product name
Periodic acid
Purity
ACS reagent, 99%
Packaging
25g
Price
$133
Updated
2025/07/31
Sigma-Aldrich
Product number
375810
Product name
Periodic acid
Purity
ACS reagent, 99%
Packaging
100g
Price
$359
Updated
2025/07/31
Sigma-Aldrich
Product number
1.00524
Product name
Periodic acid
Purity
for analysis EMSURE?
Packaging
25g
Price
$225
Updated
2025/07/31
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Periodic acid Chemical Properties,Usage,Production

Chemical Properties

Periodic acid exists as colorless crystals, soluble in water and ethanol but slightly soluble in ether. Upon dehydration, it forms metaperiodic acid (HIO₄). Further dehydration leads to decomposition, ultimately yielding iodine pentoxide (I₂O₅).

Physical properties

In dilute solution, periodic acid exists as H+ and IO4-. When more concentrated, orthoperiodic acid, H5IO6, is formed. Note that this compound is essentially a dihydrate, HIO4·2H2O. This can be obtained as a crystalline solid. O-periodic acid can be dehydrated to metaperiodic acid, m-HIO4. Further heating gives di-iodine pentoxide (I2O5) and O2. The anhydride di-iodine heptoxide, i.e. I2O7, does not exist in nature but can be formed synthetically.

Uses

Periodic acid is used as a component for glycoprotein stains. It serves as a pharmaceutical and synthetic intermediate and is used in silk screen printing. It acts as an oxidizing agent especially the cleavage of 1,2 diols to prepare dialdehydes. It has selective oxidation powers which makes it an ideal reagent for the reclamation of silk screens in the printing industry. It finds application in life sciences for the analysis of intracellular polysaccharides like glycogen, starch and cellulose. Furthermore, it is used in the oxidation reactions converting sulfides into sulfones, catalyzed by chromium(VI) oxide and oxidation reactions converting alcohols to aldehydes and ketones.

Uses

PERIODIC ACID is used as an oxidiser and in the determination of manganese.

Uses

In organic synthesis.

Definition

ChEBI: Orthoperiodic acid is an iodine oxoacid. It is a conjugate acid of an orthoperiodate(1-).

Production Methods

A 100 g quantity of Ba₃H₄(IO₆)₂ is moistened with 75 mL of H₂O and treated with 200 mL of colorless nitric acid (HNO₃). The mixture is agitated, heated to 60–70 °C for 1 h, and then cooled to 30–40 °C. The precipitated Ba(NO₃)₂ is filtered off using a glass frit filter. The residue is washed free of periodate by stirring with concentrated HNO₃. The combined filtrate is evaporated at 60–70 °C under aspirator vacuum (if additional Ba(NO₃)₂ precipitates, it is removed by filtration, and evaporation continues) until H₅IO₆ begins to crystallize. After cooling, colorless, glistening crystals of periodic acid (H₅IO₆) form. Due to the tendency of the solution to become supersaturated, prolonged waiting may be required. The crystals are collected by filtration and dried under vacuum at 50 °C. A second crop of crystals may be obtained by further evaporating the mother liquor.

Reactions

Paraperiodic acid H5IO6, is obtained from sodium paraperiodate, formed by action of chlorine upon a NaOH solution containing I2. On vacuum drying, paraperiodic acid yields metaperiodic acid, HIO4, and dimesoperiodic acid, H4I2O9; which form heteropoly acids with a number of oxides and acids. The periodic acids and their salts are strong oxidizing agents both with inorganic and organic compounds.

General Description

Periodic acid (H5IO6) is an oxoacid of iodine. It is commonly used as an oxidizing agent in organic synthesis for the preparation of useful chemical intermediates. Periodic acid is also used in oxidative cleavage reactions.

Flammability and Explosibility

Not classified

reaction suitability

reagent type: oxidant

References

[1] JACKSON E. Periodic Acid Oxidation[J]. Organic Reactions, 2011, 104 1: 341-375. DOI:10.1002/0471264180.OR002.08.
[2] FATIADI A J. Periodic Acid, a Novel Oxidant of Polycyclic, Aromatic Hydrocarbons.[J]. Journal of Research of the National Bureau of Standards. Section A, Physics and Chemistry, 1968, 72A 4: 341-350. DOI:10.6028/jres.072A.030.
[3] MAHDIEH TABATABAEI SHAFIEI. Detecting glycogen in peripheral blood mononuclear cells with periodic acid schiff staining.[J]. Jove-Journal of Visualized Experiments, 2014, 94. DOI:10.3791/52199.
[4] ZACHARY J WOLNER Benjamin K S Danielle E Mustin. Preordering Periodic Acid-Schiff Staining: A Quality Improvement Study.[J]. American Journal of Dermatopathology, 2023: 825-827. DOI:10.1097/DAD.0000000000002570.
[5] SH. N. ZHURAKULOV. Oxidation of Quinoline Alkaloids Bucharaine, Foliosidine, Evoxine, and Dubinidine by Periodic Acid[J]. Chemistry of Natural Compounds, 2024, 60 4: 676-682. DOI:10.1007/s10600-024-04410-7.

Periodic acid Preparation Products And Raw materials

Raw materials

Hydrochloric acid Sodium periodate Sodium hydroxide Sulfuric acid

Preparation Products

2-FLUORO-3-IODO-5-NITROPYRIDINE S-METHYL-S-(4-METHOXYPHENYL) SULFOXIMINE S-METHYL-S-(5-METHYLFURAN-2-YL) SULFOXIMINE S-METHYL-S-(4-HYDROXYPHENYL) SULFOXIMINE 2-Fluoropyridine-5-boronic acid S-METHYL-S-(2-THIAZYL) SULFOXIMINE S-METHYL-S-(2-FLUOROYPHENYL) SULFOXIMINE S-METHYL-S-(4-CHLOROPHENYL) SULFOXIMINE Ammonium periodate S-METHYL-S-(3-ACETAMIDOPHENYL) SULFOXIMINE S-METHYL-S-(4-METHYLPHENYL) SULFOXIMINE S-ETHYL-S-PHENYL SULFOXIMINE Potassium periodate Sodium periodate DIBENZYL SULFOXIDE 2-Fluoro-5-iodopyridine S-METHYL-S-BENZYL SULFOXIMINE 2-METHOXY-6-METHYLBENZOIC ACID ETHYL ESTER 5-IODOCYTOSINE 2-Chloro-5-iodopyridine S-METHYL-S-(4-FLUOROPHENYL) SULFOXIMINE
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View Lastest Price from Periodic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
PERIODIC ACID 10450-60-9
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-22
Hebei Yanxi Chemical Co., Ltd.
Product
PERIODIC ACID 10450-60-9
Price
US $30.00-2.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
30 tons
Release date
2023-09-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Periodic Acid 10450-60-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

10450-60-9, Periodic acidRelated Search:

Lead dioxide Sodium fluoride SODIUM BISMUTHATE Sodium iodate Iodic acid Sodium periodate Periodic acid LITHIUM PERIODATE Ammonium periodate Tetrabutylammonium periodate Potassium periodate BARIUM PERIODATE PERIODIC ACID SODIUM PARAPERIODATE POTASSIUM NICKEL(IV) PARAPERIODATE TRIS[TRINITRATOCERIUM(IV)] PARAPERIODATE SILVER PERIODATE Potassium paraperiodate

  • Periodic acid, ACS, 99.01-101.0%
  • Periodate
  • Periodic Acid, ACS
  • PERIODIC ACID FOR ANALYSIS EMSURE
  • Periodic acid SynonyMs Orthoperiodic acid
  • Periodic acid 99.999% trace metals basis
  • Periodic acid puriss. p.a., ACS reagent, for oxidimetric titration, crystallized, >=99.0% (RT)
  • Periodic acid ReagentPlus(R), >=99.0%
  • Periodic acid, ACS, 99.0-101.0%
  • PERIODIC ACID, 99%, A.C.S. REA
  • Periodic acidACS reagent, 99.0-101.0% (Assay)
  • Iodine(VII)pentahydoxideoxide
  • Periodic acid
  • Pentahydroxy-l5-iodane oxide
  • PERIODIC ACID, DIHYDRATE
  • ORTHOPERIODIC ACID
  • PARA-PERIODIC ACID
  • DNTP MIXTURE 10 MM BIOTECHNOLOGY GRADE
  • periodic
  • periodicacid(h5io6)
  • Periodicacidwwaqsoln
  • PERIODIC ACI
  • PERIODIC ACID, REAGENTPLUS TM >= 99.0%
  • PERIODIC ACID, CRYSTALLIZED
  • PERIODIC ACID, 99.999%
  • PERIODIC ACID SOLUTION
  • PERIODIC ACID, 99%, A.C.S. REAGENT
  • PERIODIC ACID SIGMAULTRA
  • PERIODIC ACID ACS REAGENT
  • PERIODIC ACID REAGENT GRADE 98%
  • PERIODIC ACID, ACS, CRYSTALLIZED
  • ORTHO-PERIODIC ACID PURE
  • PeriodicAcidGr
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  • PeriodicAcid50%
  • Periodic acid, 34% w/w aq. soln.
  • PeriodicAcide
  • Periodic acid, 99+%
  • PERIODIC ACID REAGENT (ACS)
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  • PERIODIC ACID: 34% W/W AQUEOUS SOLUTION
  • PERIODIC ACID, 99.99+%PERIODIC ACID, 99.99+%PERIODIC ACID, 99.99+%PERIODIC ACID, 99.99+%
  • PERIODIC ACID, REAGENT (ACS)PERIODIC ACID, REAGENT (ACS)PERIODIC ACID, REAGENT (ACS)PERIODIC ACID, REAGENT (ACS)
  • PERIODIC ACID, SOLUTION, 50%PERIODIC ACID, SOLUTION, 50%PERIODIC ACID, SOLUTION, 50%PERIODIC ACID, SOLUTION, 50%
  • PERIODIC ACID FOR SYNTHESIS 100 G
  • PERIODIC ACID FOR SYNTHESIS 500 G
  • PERIODIC ACID ISO 9001：2015 REACH
  • Periodic acid AR 25GM
  • Periodic acid AR 100GM
  • Periodic acid AR 99%
  • Periodic acid, GR 99%+
  • pentahydroxy(oxo)-
  • Periodic Acid, Certified AR for Analysis, Fisher Chemical
  • Periodic Acid extrapure, 99%
  • Pentahydroxy-λ5-iodane oxide
  • PERIODIC ACID 99.5%
  • Periodic Acid 99% For Synthesis
  • 10450-60-9