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Cromolyn Disodium Salt

Description References
Product Name
Cromolyn Disodium Salt
CAS No.
15826-37-6
Chemical Name
Cromolyn Disodium Salt
Synonyms
SODIUM CROMOGLYCATE;CROMOLYN SODIUM;SODIUM CROMOGLICATE;Cromoglycate;Cromoglycate Sodium;DISODIUM CROMOGLYCATE;DSCG;intal;Allergocrom;SODIUM CHROMOGLICATE
CBNumber
CB3413920
Molecular Formula
C23H17NaO11
Formula Weight
492.37
MOL File
15826-37-6.mol
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Cromolyn Disodium Salt Property

Melting point:
241-2420C (dec)
storage temp. 
2-8°C
solubility 
Soluble in water, practically insoluble in ethanol (96 per cent).
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble in water to 100mg/ml
Merck 
14,2590
Stability:
Hygroscopyc
InChIKey
VLARUOGDXDTHEH-UHFFFAOYSA-L
CAS DataBase Reference
15826-37-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
3249
WGK Germany 
2
RTECS 
DJ2380000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29329990
Toxicity
LD50 in mice, rats (mg/kg): >8000 orally (Cox)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C0399
Product name
Cromolyn sodium salt
Purity
≥95%
Packaging
1g
Price
$72.8
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2727
Product name
Cromolyn Sodium
Purity
Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 1?g
Packaging
1G
Price
$267
Updated
2024/03/01
Sigma-Aldrich
Product number
1150502
Product name
Cromolyn sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
C2521
Product name
Cromolyn Disodium Salt Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$117
Updated
2024/03/01
TCI Chemical
Product number
C2521
Product name
Cromolyn Disodium Salt Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$396
Updated
2024/03/01
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Cromolyn Disodium Salt Chemical Properties,Usage,Production

Description

Sodium cromoglycate is the sodium salt and common market from of cromoglicic acid, which is a synthetic compound, and as a mast cell stabilizer. It is capable of inhibiting the antigen-induced bronchospasms, and thus being used to treat the asthma and allergic rhinitis. It can also be applied as an ophthalmic solution for the treatment of conjunctivitis and systemic mastocytosis and ulcerative colitis. It is capable of inhibiting the degranulation of mast cells, further preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), the mediators of type I allergic reaction. It is also capable of inhibiting the release of inflammatory leukotrienes and inhibiting calcium influx.

References

https://www.drugbank.ca/drugs/DB01003
https://en.wikipedia.org/wiki/Cromoglicic_acid

Description

Disodium cromoglycateis a relatively nontoxic agent used for the long-term prevention of many types of asthma. It has no bronchodilator properties and is used in the prophylaxis of asthma. It does not play a role in the treatment of acute asthmatic attacks including severe asthma.

Chemical Properties

White Crystalline Powder

Originator

Intal,Fisons,UK,1969

Uses

Chromone complex which blocks mast cell degranulation

Uses

antiasthmatic, antiallergy

Uses

Anti Asthamatic

Definition

ChEBI: An organic sodium salt that is the disodium salt of cromoglycic acid.

Indications

Cromolyn sodium (Intal) is chemically related drugs called chromones that is used for the prophylaxis of mild or moderate asthma. It is administered by inhalation and has very good safety profiles, making them particularly useful in treating children.

Manufacturing Process

To a solution of 970 parts of 2,6-dihydroxyacetophenone and 325 parts of epichlorohydrin in 1,500 parts of hot isopropanol was added, with stirring under reflux, a solution of 233 parts of 85% KOH in 2,500 parts of isopropanol and sufficient water (ca 100 parts) to dissolve the solid. The mixture was heated, with stirring, under reflux for 48 hours. Half the solvent was then distilled off and 5,000 parts of water were added. The mixture was cooled and the solid filtered off and washed with isopropanol and ether. It was then recrystallized from 12,500 parts of isopropanol to obtain a first crop of 380 parts and a second crop, after concentration, of 300 parts of 1,3-bis(2- acetyl-3-hydroxyphenoxy)-2hydroxypropane.
4.6 parts of 1,3-bis(2-acetyl-3-hydroxyphenoxy)-2-hydroxypropane were reacted with diethyl oxalate and the product cyclized to obtain 4.4 parts of pure diethyl ester of 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane as pale yellow crystals melting between 180° and 182°C from a mixture of benzene and petrol, 4 parts of the diethyl ester of 1,3-bis(2-carboxychromon5-yloxy)-2-hydroxypropane were saponified with sodium hydroxide to obtain 3.2 parts of the disodium salt tetrahydrate as colorless crystals from aqueous alcohol.

Therapeutic Function

Bronchodilator

General Description

Cromolyn sodium, disodium 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane (Intal), isa hygroscopic, white, hydrated crystalline powder that is solublein water (1:10). It is tasteless at first but leaves a veryslightly bitter aftertaste. The pK of cromolyn is 2. It is availableas a solution for a nebulizer, an aerosol spray, a nasal solution,an ophthalmic solution, and an oral concentrate.
Nebulized and aerosol cromolyn has been used for prophylacticmanagement of bronchial asthma and prevention ofexercise-induced bronchospasm. Cromolyn nasal solution isused for the prevention and treatment of allergic rhinitis, andoral concentrate is used to treat the histaminic symptomsof mastocytosis (diarrhea, flushing, headaches, vomiting, urticaria,abdominal pain, nausea, and itching). Topical cromolyn(eye drops) is used to treat allergic conjunctivitis andkeratitis. In the treatment of asthma, cromolyn efficacy is manifestedby decreased severity of clinical symptoms, or need for concomitant therapy, or both. Long-term use is justified if thedrug significantly reduces the severity of asthma symptoms;permits a significant reduction in, or elimination of, steroiddosage; or improves management of those who have intolerableside effects to sympathomimetic agents or methylxanthines.For cromolyn to be effective, it must be administered atleast 30 minutes prior to antigen challenge and administered atregular intervals (see dosing information that follows). Wheninhaled, the powder does produce irritation in some patients.Also, overuse of cromolyn can result in tolerance.

Biochem/physiol Actions

Cromolyn blocks the release of histamine and other pro-inflammatory mediators from mast cells.

Mechanism of action

The precise mechanism or mechanisms whereby cromolyn sodium and nedocromil sodium exert their antiasthmatic activities is unknown. Early work suggested that these agents act by “stabilizing” mast cells, preventing mediator release. However, several other compounds exhibit greater potency for stabilization of mast cells yet possess no clinical efficacy in asthma.This suggests that the therapeutic activity of cromolyn sodium and nedocromil sodium in asthma is related to one or more other pharmacological mechanisms. Postulates include inhibitory effects on irritant receptors, nerves, plasma exudation, and inflammatory cells in general.

Pharmacokinetics

Cromolyn sodium is a bischromone that contains the fundamental benzopyrone moiety of khellin. The two chromone rings are necessary for activity and must be coplanar, with a linking chain of no longer than six carbons. If one changes the linking chain to positions 8 and 8′, coplanarity cannot be maintained, and the compound loses all activity. Cromolyn sodium is poorly absorbed from the lungs (~8%), insignificantly from the eye (~0.07%), and by approximately 1% from the GI tract. What little that finds its way into systemic circulation is eliminated intact in the urine and the bile. For the treatment of asthma, cromolyn sodium is available as a solution for both intranasal and inhalation administration. There also is an oral concentrate (100 mg/5 mL), which is administered as a 200-mg dose given four times a day.

Clinical Use

Cromolyn sodium is used almost exclusively for the prophylactic treatment of mild to moderate asthma and should not be used for the control of acute bronchospasm. This agent is effective in about 60 to 70% of children and adolescents with asthma. Unfortunately, there is no reliable means to predict which patients will respond.It is less effective in older patients and in patients with severe asthma. It may take up to 4 to 6 weeks of treatment for cromolyn sodium to be effective in chronic asthma, but it is effective after a single dose in exercise-induced asthma. With respect to clinical efficacy, cromolyn sodium and nedocromil sodium do not differ in a substantial way.

Side effects

Cromolyn sodium is the least toxic of available therapies for asthma. Adverse reactions are rare and generally minor. Those occurring in fewer than 1 in 10,000 patients include transient bronchospasm, cough or wheezing, dryness of throat, laryngeal edema, swollen parotid gland, angioedema, joint swelling and pain, dizziness, dysuria, nausea, headache, nasal congestion, rash, and urticaria.

storage

Store at RT

Cromolyn Disodium Salt Preparation Products And Raw materials

Raw materials

Diethyl oxalate Resorcinol Diethyl cromoglycate Epichlorohydrin Isopropyl alcohol 2',6'-Dihydroxyacetophenone

Preparation Products

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View Lastest Price from Cromolyn Disodium Salt manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Sodium Cromoglycate 15826-37-6
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-21
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cromolyn Disodium Salt 15826-37-6
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%-102%
Supply Ability
1000KGS
Release date
2021-06-24
Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
Cromolyn Disodium Salt 15826-37-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1000
Release date
2025-01-16

15826-37-6, Cromolyn Disodium SaltRelated Search:

Sodium hydroxide Sodium benzoate Sodium sulfate Ethylenediaminetetraacetic acid disodium salt Sodium chlorite Sodium bicarbonate 1-Propanol Sodium carbonate Diclofenac sodium Sodium formate Sodium silicate Sodium acetate Sodium chloride Trisodium phosphate Sodium Monofluorophosphate Sodium Cromoglicate Impurity 13 Sodium Cromoglicate Impurity 7 Sodium cromoglicate impurity 5 Cromolyn Sodium Sodium Cromoglicate

  • DSCG
  • DISODIUM CROMOGLYCATE
  • disodium 5,5'-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-4h-1-benzopyran-2-carboxylate]
  • disodium 1,3-bis(2-carboxy-5-chromonyloxy)-2-propanol
  • CROMOGLYCATE SODIUM SALT
  • CROMOGLYCIC ACID SODIUM SALT
  • CROMOLYN SODIUM
  • CROMOLYN SODIUM SALT
  • sodium 5-[3-[(2-carboxy-4-oxo-1-benzopyran-5-yl)oxy]-2-hydroxypropoxy]-4-oxo-1-benzopyran-2-carboxylic acid
  • SODIUM CROMOGLICATE
  • SODIUM CROMOGLYCATE
  • 4h-1-benzopyran-2-carboxylicacid,5,5’-((2-hydroxytrimethylene)dioxy)bis(4-oxo
  • 4H-1-Benzopyran-2-carboxylicacid,5,5’-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-,disodiumsalt
  • 4H-1-Benzopyran-2-carboxylicacid,5,5’-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-,disodiumsalt
  • 5,5’-((2-hydroxytrimethylene)dioxy)bis(4-oxo-4h-1-benzopyran-2-carboxylicaci
  • 5,5’-[2-Hydroxy-1,3-propanediyl)bis-(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylicacid]disodiumsalt
  • aarane
  • aararre
  • cromoglycatedisodium
  • Cromoglycicacidsodium
  • d)disodiumsalt
  • dinatriumsalzvon1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan
  • disodium5,5’-((2-hydroxytrimethylene)dioxy)-bis(4-oxo-4h-1-benzopyran-2-carb
  • disodium5,5’-[(2-hydroxytrimethylene)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylate]
  • disodiumchromoglycate
  • disodiumcromoglicate
  • fpl670
  • frenasma
  • inostral
  • intal
  • lomudal
  • lomudas
  • nalcrom
  • nasmil
  • natriumcromoglicat
  • oxylate)
  • rynacrom
  • sodiumcromolyn
  • 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-4h-1-benzopyran-2-carboxylic acid) disodium salt
  • SODIUM CHROMOGLICATE
  • CROMOLYN SODIUM (DISODIUM CROMOGLYCATE)
  • Disodium 5,5-[(2-hydroxytrimethylene)-bis-(oxy)]-bis[4-oxo--1-benzopyran-2
  • Cromoglycate Sodium
  • 1,3-Di-(2-carboxy-4-oxochromen-5-yloxy) propan-2-ol-disodium salt
  • Cromoglycic acid, disodium salt
  • Allergocrom
  • Alloptrex
  • Cromolyn Disodium Salt
  • Nalcro
  • CROMOLYNSODIUM,USP
  • SODIUM CHROMOGLYCATE
  • Cromoiyn Sodium
  • Sodium Cromoglycate 5,5’-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic Acid] Disodium Salt
  • Dissodium cromoglicate
  • Cromoglicate Sodium
  • Cromolyn sodium salt,Cromoglycate, Cromoglycic acid
  • Cromolyn Sodium (500 mg)
  • CroMolyn DisodiuM Salt Hydrate