4-BETA-HYDROXYCHOLESTEROL

Product Name: 4-BETA-HYDROXYCHOLESTEROL
CAS No.: 17320-10-4
Chemical Name: 4-BETA-HYDROXYCHOLESTEROL
Synonyms: 4-Hydroxy Cholesterol;4--Hydroxy Cholestrol;cholest-5-ene-3,4-diol;4β-Hydroxy Cholesterol;Cholesterol Impurity 30;5-CHOLESTEN-3β, 4β-DIOL;4-BETA-HYDROXYCHOLESTEROL;4β-Hydroxycholesterol-[d4];4β-Hydroxycholesterol-[d5];2H4]-4β-Hydroxycholesterol
CBNumber: CB3417069
Molecular Formula: C27H46O2
Formula Weight: 402.65
MOL File: 17320-10-4.mol

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4-BETA-HYDROXYCHOLESTEROL Property

Melting point:: 172-174°C
Boiling point:: 500.2±30.0 °C(Predicted)
Density: 1.03±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 14.32±0.70(Predicted)
color: White to Pale Beige

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Safety

HS Code: 9999999999

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R208795
Product name: CHOLEST-5-ENE-3-BETA,4-BETA-DIOL
Purity: AldrichCPR
Packaging: 1MG
Price: $29.8
Updated: 2024/03/01

Cayman Chemical

Product number: 19518
Product name: 4β-hydroxy Cholesterol
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19518
Product name: 4β-hydroxy Cholesterol
Purity: ≥98%
Packaging: 5mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 19518
Product name: 4β-hydroxy Cholesterol
Purity: ≥98%
Packaging: 10mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 19518
Product name: 4β-hydroxy Cholesterol
Purity: ≥98%
Packaging: 25mg
Price: $283
Updated: 2024/03/01

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4-BETA-HYDROXYCHOLESTEROL Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.

Definition

ChEBI: A oxysterol that is cholesterol in which the hydrogen at the 4beta position has been replaced by a hydroxy group. A metabolite of cholesterol formed by the drug-metabolizing enzyme cytochrome P450 3A4, it is one of the major oxysterols in he human circulation.

Biological Activity

4β-hydroxy cholesterol is an endogenous marker for cyp3a4/5 activity [1].cytochome p450 3a4 (cyp3a4) and cyp3a5 are important drug-metabolizing enzymes that oxidize small foreign organic molecules, such as toxins or drugs, and remove them from the body. they exhibit a large variation in hepatic expression and biological activity between different individuals. patients treated with drugs known to be strong inducers of cyp3a4/5 have highly elevated levels of 4β-hydroxycholesterol in the circulation [1].4β-hydroxy cholesterol, an endogenous oxysterol found in human circulation, is formed from cholesterol by cytochrome p450 (cyp) 3a4 and cyp3a5. in 12 different occasions during a 3-month period, the cvs for 4β-hydroxycholesterol ranged from 4.8 to 13.2% with an average cv of 7.1% at an average concentration of 30.8 ng/ml. in 24 volunteers treated with rifampicin, a strong cyp3a4/5 inducer, 4β-hydroxycholesterol increased in a dose-dependent way, while the isomer 4α-hydroycholesterol was not influenced by rifampicin treatment. these results suggested that 4β-hydroxy cholesterol is an endogenous marker for cyp3a4/5 activity [1].

References

[1]. diczfalusy u, kanebratt kp, bredberg e, et al. 4beta-hydroxycholesterol as an endogenous marker for cyp3a4/5 activity. stability and half-life of elimination after induction with rifampicin. br j clin pharmacol. 2009 jan;67(1):38-43.

4-BETA-HYDROXYCHOLESTEROL Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BETA-HYDROXYCHOLESTEROL Suppliers

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17320-10-4, 4-BETA-HYDROXYCHOLESTEROLRelated Search:

5-CHOLESTEN-3-BETA, 4-BETA-DIOL DIACETATE 4-BETA-HYDROXYCHOLESTEROL

4-BETA-HYDROXYCHOLESTEROL

5-CHOLESTEN-3-BETA, 4-BETA-DIOL

cholest-5-ene-3,4-diol

4-Hydroxy Cholesterol

(3beta,4beta)-Cholest-5-ene-3,4-diol

Cholest-5-ene-3,4-diol, (3beta,4beta)-

Cholest-5-ene-3beta,4beta-diol

cis-3,4-Dihydroxy-delta5-cholestene

cis-delta5-Cholestene-3,4-diol

3beta,4beta-Dihydroxycholest-5-ene

Cholest-5-ene-3,4-diol, (3b,4b)-

4--Hydroxy Cholestrol

4β-Hydroxycholesterol-[d4]

4β-Hydroxy Cholesterol

4β-Hydroxycholesterol-[d5]

Cholesterol Impurity 30

2H4]-4β-Hydroxycholesterol

Cholest-5-ene-3,4-diol, (3β,4β)-

5-CHOLESTEN-3β, 4β-DIOL

Monostearin Impurity 15 (Ethyl Stearate)

17320-10-4

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Steroids