4-CHLOROBENZHYDRAZIDE
- Product Name
- 4-CHLOROBENZHYDRAZIDE
- CAS No.
- 536-40-3
- Chemical Name
- 4-CHLOROBENZHYDRAZIDE
- Synonyms
- INHd 15;NSC 54990;AKOS 92880;AKOS BBS-00004505;TIMTEC-BB SBB003853;4-CHLOROBENZHYDRAZIDE;p-Chlorobenzhydrazide;4-CHLOROBENZOHYDRAZIDE;P-CHLOROBENZOHYDRAZIDE;LABOTEST-BB LT00053515
- CBNumber
- CB3419164
- Molecular Formula
- C7H7ClN2O
- Formula Weight
- 170.6
- MOL File
- 536-40-3.mol
4-CHLOROBENZHYDRAZIDE Property
- Melting point:
- 162-165 °C (lit.)
- Boiling point:
- 170.60°C
- Density
- 1.323
- refractive index
- 1.5618 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 12.09±0.10(Predicted)
- color
- White to Almost white
- BRN
- 511154
- InChI
- InChI=1S/C7H7ClN2O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,9H2,(H,10,11)
- InChIKey
- PKBGHORNUFQAAW-UHFFFAOYSA-N
- SMILES
- C(NN)(=O)C1=CC=C(Cl)C=C1
- CAS DataBase Reference
- 536-40-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 259616
- Product name
- 4-Chlorobenzhydrazide
- Purity
- 98%
- Packaging
- 5g
- Price
- $31.7
- Updated
- 2025/07/31
- Product number
- C2060
- Product name
- 4-Chlorobenzohydrazide
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- C2060
- Product name
- 4-Chlorobenzohydrazide
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $200
- Updated
- 2025/07/31
- Product number
- C427653
- Product name
- 4-Chlorobenzohydrazide
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 269291
- Product name
- 4-Chlorobenzhydrazide
- Packaging
- 10g
- Price
- $207
- Updated
- 2021/12/16
4-CHLOROBENZHYDRAZIDE Chemical Properties,Usage,Production
Chemical Properties
white to light beige crystals, flakes or
Uses
4-Chlorobenzhydrazide has been used in preparation of:
- rod-shaped mesogenic hydrazide derivatives via Schotten-Baumann reaction with 4-n-alkoxybenzoyl chloride
- 4-methoxybenzaldehyde-4-chlorophenyl-1-carbonyl hydrazone
- 4-hydroxybenzaldehyde-4-chlorophenyl-1-carbonylhydrazone
- 2-nitrobenzaldehyde-4-chlorophenyl-1-carbonylhydrazone
- benzaldehyde-4-chlorophenyl-1-carbonylhydrazone
General Description
Effect of acidic catalyst on the reaction of 4-chlorobenzhydrazide and β-naphthol in water has been investigated.
Synthesis
7335-27-5
536-40-3
General procedure for the synthesis of 4-chlorobenzoyl hydrazine from ethyl p-chlorobenzoate: hydrazine was synthesized conventionally using the one-pot method (30-58% yield). 10 mmol of ethyl p-chlorobenzoate was dissolved in 20 mL of ethanol. 2 mL of 3N sulfuric acid was added to the solution and the reaction mixture was refluxed for 6 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was neutralized with solid NaHCO3 and filtered to remove excess NaHCO3. To the neutralized reaction mixture, 1.5 mL (3 mmol) of hydrazine monohydrate was added and refluxing was continued for 3-6 h to ensure complete reaction. The ethanol and unreacted hydrazine were evaporated to 1/3 of the original volume by distillation.The reaction mixture was cooled to room temperature, the product was collected by filtration and recrystallized from methanol to give pure 4-chlorobenzhydrazide crystals (see Supporting Information for specific data).
Purification Methods
Crystallise it from H2O. [Beilstein 9 III 1368.]
References
[1] Medicinal Chemistry Research, 2013, vol. 22, # 6, p. 2755 - 2767
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 6014 - 6024
[3] Patent: CN106008390, 2016, A. Location in patent: Paragraph 0015
[4] Journal of Heterocyclic Chemistry, 1992, vol. 29, # 5, p. 1101 - 1109
[5] Oriental Journal of Chemistry, 2017, vol. 33, # 2, p. 971 - 978
4-CHLOROBENZHYDRAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLOROBENZHYDRAZIDE manufacturers
- Product
- 4-Chlorobenzhydrazide 536-40-3
- Price
- US $220.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 500g;1kg;5kg;10kg;100kg;
- Release date
- 2019-04-15
- Product
- 4-CHLOROBENZHYDRAZIDE 536-40-3
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-13