Ifenprodil

Product Name: Ifenprodil
CAS No.: 23210-56-2
Chemical Name: Ifenprodil
Synonyms: IFENPRODIL;2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propanol;4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol;2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol;2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propan-1-ol;1-(4-Hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol;4-[2-[4-(benzyl)-1-piperidyl]-1-hydroxy-propyl]phenol;4-Benzyl-α-(p-hydroxyphenyl)-β-methyl-1-piperidineethanol;4-[1-Hydroxy-2-[4-(phenylmethyl)piperidin-1-yl]propyl]phenol;2-?(4-?Benzylpiperidino)?-?1-?(1-?hydroxyphenyl)?-?1-?propanol
CBNumber: CB3427239
Molecular Formula: C21H27NO2
Formula Weight: 325.45
MOL File: 23210-56-2.mol

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Ifenprodil Property

Melting point:: 114°
Boiling point:: 463.62°C (rough estimate)
Density: 1.0825 (rough estimate)
refractive index: 1.5614 (estimate)
storage temp.: Store at RT
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9.99±0.26(Predicted)
color: White to Off-White
Water Solubility: Soluble to 15 mM in water with gentle warming

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Safety

Toxicity: LD50 oral in mouse: 320mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J60932
Product name: Ifenprodil hemitartrate, 99%
Packaging: 10mg
Price: $84.65
Updated: 2024/03/01

Alfa Aesar

Product number: J60932
Product name: Ifenprodil hemitartrate, 99%
Packaging: 50mg
Price: $312.65
Updated: 2024/03/01

TRC

Product number: I258003
Product name: Ifenprodil
Packaging: 100mg
Price: $410
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0002060
Product name: 1-METHYL-2-HYDROXY-2-(4-HYDROXYPHENYL)ETHYL-1-(4-BENZYLPIPERIDINE)
Purity: 95.00%
Packaging: 10MG
Price: $617.3
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0002060
Product name: 1-METHYL-2-HYDROXY-2-(4-HYDROXYPHENYL)ETHYL-1-(4-BENZYLPIPERIDINE)
Purity: 95.00%
Packaging: 50MG
Price: $842.87
Updated: 2021/12/16

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Ifenprodil Chemical Properties,Usage,Production

Originator

Vadilex,Carriere,France,1972

Uses

Ifenprodil is a NMDA receptor antagonist.

Uses

vasodilator

Definition

ChEBI: 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol is a member of piperidines.

Manufacturing Process

The initial steps involve reacting benzyl chloride with 4- hydroxypropiophenone. The benzyloxypropiophene thus obtained is first brominated and then reacted with 4-benzylpiperidine to give 1-(pbenzyloxyphenyl)-2-(4-benzyl-piperidino)propan-1-one.
The neutral tartrate may be prepared directly by reduction of 1-(pbenzyloxyphenyl)-2-(4-benzyl-piperidino)propan-1-one. For the reduction, a mixture of 175 g of ketone (0.425 mol) and 32 g of tartaric acid (0.213 mol) is hydrogenated at 50°C under pressure of 50 kg/cm2 in 440 ml of methanol in the presence of 12 g of palladium on charcoal.
The catalyst is filtered off at elevated temperature, and the filtrate is concentrated by evaporation under reduced pressure to a volume of 300 ml and added in a thin stream to 2.5 liters of diethyl ether with mechanical agitation. The precipitate is separated, washed with diethyl ether and dried in vacuo at 80° to 85°C for several hours. 325 g (96% yield) of the neutral tartrate of 1-(p-hydroxyphenyl)-2-(4-benzyl-piperidino)propan-1-ol are obtained.

Therapeutic Function

Vasodilator

Biological Activity

NMDA receptor antagonist, acting at the polyamine site. Also an α -adrenergic vasodilator. σ 2 ligand displaying about 3-fold selectivity over σ 1 sites.

Ifenprodil Preparation Products And Raw materials

Raw materials

Preparation Products

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Ifenprodil Suppliers

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23210-56-2, IfenprodilRelated Search:

Benzyl chloride Diltiazem Fasudil hydrochloride CHLOROPHOSPHONAZO III Propyl gallate Benzyltriethylammonium chloride Haloperidol Diphenylsilanediol Buflomedil hydrochloride Prostaglandin E1 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil 1-Propanol 3-Aminophenol Propyl butyrate Phenol Red Phenol IFENPRODIL TARTRATE SALT,IFENPRODIL TARTARATE,IFENPRODIL HEMITARTRATE,Ifenprodil L-(+)-Tartrate,IFENPRODIL TARTRATE Diphenoxylate

4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethano

4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethanol

alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidineethano

IFENPRODIL

2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol tartrate (2:1) salt

1-(4-Hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol

2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propan-1-ol

4-Benzyl-α-(p-hydroxyphenyl)-β-methyl-1-piperidineethanol

α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidineethanol

1-Methyl-2-hydroxy-2-(4-hydroxyphenyl)ethyl-1-(4-benzylpiperidine)

2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol

alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidineethanol

2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propanol

4-[1-Hydroxy-2-[4-(phenylmethyl)piperidin-1-yl]propyl]phenol

4-[2-[4-(benzyl)-1-piperidyl]-1-hydroxy-propyl]phenol

1-Piperidineethanol, .alpha.-(4-hydroxyphenyl)-.beta.-methyl-4-(phenylmethyl)-

(1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanolhemitartrate

4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol

4-[(1S,2R)-1-hydroxy-2-[4-(phenylmethyl)-1-piperidin-1-iumyl]propyl]phenol

(1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemi-(DL)-tartrate

2-?(4-?Benzylpiperidino)?-?1-?(1-?hydroxyphenyl)?-?1-?propanol

1-Piperidineethanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-

23210-56-2

C46H60N2O10

C21H27NO2189C4H6O6

Glutamate receptor

API