Diltiazem
- Product Name
- Diltiazem
- CAS No.
- 42399-41-7
- Chemical Name
- Diltiazem
- Synonyms
- DILTIAZEN;Dilthiazem;(2S,3S)-5-(2-(diMethylaMino)ethyl)-2-(4-Methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate;Coras;NSC7324;NSC 7324;NSC-7324;DILTIAZEM;Adizem XL;d-Diltiazem
- CBNumber
- CB5715839
- Molecular Formula
- C22H26N2O4S
- Formula Weight
- 414.52
- MOL File
- 42399-41-7.mol
Diltiazem Property
- Melting point:
- 212 °C (decomp)
- Boiling point:
- 594.4±50.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- pKa 7.70 (Uncertain)
- color
- White to Off-White
- CAS DataBase Reference
- 42399-41-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Diltiazem(42399-41-7)
- EPA Substance Registry System
- 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)- (42399-41-7)
Safety
- Hazardous Substances Data
- 42399-41-7(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- D460628
- Product name
- Diltiazem
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FD44512
- Product name
- Diltiazem
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- API0005791
- Product name
- DILTIAZEM
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $155.4
- Updated
- 2021/12/16
- Product number
- FD44512
- Product name
- Diltiazem
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FD44512
- Product name
- Diltiazem
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
Diltiazem Chemical Properties,Usage,Production
Originator
Herbesser,TANABE SEIYAKU,Japan,1974
Uses
It is used for stable and nonstable angina pectoris (including after myocardial infarctions) as well as in arterial hypertension.
Uses
Diltiazem is a potent vasodilator compound. Antihypertensive.
Definition
ChEBI: A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the m nagement of angina pectoris and hypertension.
Manufacturing Process
β-Diethylaminoethyl chloride is condensed with 2-(4-methoxyphenyl)-3-
hydroxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one in a first step. Then a
mixture of 1.5 grams of 2-(4-methoxyphenyl)-3-hydroxy-5-(βdimethylaminoethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one and 20 ml of
acetic anhydride was heated on a water bath for 5 hours. The reaction
mixture was evaporated under reduced pressure to remove acetic anhydride
and the concentrated product was poured into ice water. The resulting mixture
was made alkaline with sodium bicarbonate and extracted with chloroform.
The chloroform layer was dried and evaporated to remove the solvent. The
residue was dissolved in acetone, and an ethanol solution containing hydrogen
chloride was added thereto producing 1.53 grams of 2-(4-methoxyphenyl)3-
acetoxy-5-(β-dimethylaminoethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
hydrochloride having a melting point from 187° to 188°C.
The starting material is made by reacting 4-methoxybenzaldehyde with ethyl
chloroacetate; that product with sodium ethoxide; and that product with 2-
aminothiophenol.
Therapeutic Function
Coronary vasodilator
Mechanism of action
Diltiazem reduces the transmembrane influx of calcium ions into cells of cardiac muscle and smooth musculature of vessels. It causes dilation of coronary and peripheral vessels, increases coronary blood flow, and prevents development of coronary artery spasms. It lowers elevated arterial pressure and reduces tachycardia.
Clinical Use
The antiarrhythmic actions and uses of diltiazem are similar to those of verapamil. Diltiazem is effective in controlling the ventricular rate in patients with atrial flutter or atrial fibrillation.
Synthesis
Diltiazem, 5-[2-(diethylamino)ethyl]-cis-2,3-dihydro-3-hydroxy-2- (4-methoxy-phenyl)-1,5-benzothiazepin-4(5H)-one (19.3.10), is synthesized in the following manner. The condensation of 4-methoxybenzaldehyde with methylchoroacetate in the presence of sodium methoxide in Darzens reaction conditions gives methyl ester of 3- (4-methoxyphenyl)-glycidylic acid (19.3.5). Reacting it with 2-aminothiophenol with the opening of epoxide ring gives methyl ester of 2-hydroxy-3-(2'-aminophenylthio)-3- (4"- methoxyphenyl)propionic acid (19.3.6). Hydrolysis of the resulting compound with alkali leads to the formation of the corresponding acid (19.3.7) in the form of a racemic mixture, which when on interaction with (+)-|á-phenylethylamine gives threo-(+)-2-hydroxy-3-(2'- aminophenylthio)-3-(4"-methoxyphenylpropionic acid (19.3.8). Boiling this in a mixture of acetic anhydride/dimethylformamide/pyridine system brings to cyclization to the thiazepine ring and simultaneously acylates the hydroxyl group, forming (+)-cis-2-(4-methoxyphenyl)- 3-acetoxy-2,3-dihydro-1,5-benzothiazepin-4-(5H)-one (19.3.9). Alkylation of the resulting product with 2,2-dimethylaminoethylchloride forms diltiazem (19.3.10).
Diltiazem Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diltiazem manufacturers
- Product
- Diltiazem 42399-41-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-31
- Product
- Diltiazem 42399-41-7
- Price
- US $13.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 200ton
- Release date
- 2024-06-19
- Product
- Diltiazem 42399-41-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-06-03