2-PHENYL-1,3-INDANDIONE
- Product Name
- 2-PHENYL-1,3-INDANDIONE
- CAS No.
- 83-12-5
- Chemical Name
- 2-PHENYL-1,3-INDANDIONE
- Synonyms
- PHENINDIONE;PID;Indion;MTA2;Hedulin;2-Phenyl-1H-indene-1,3(2H)-dione;Indon;Bindan;Indema;MTA1L1
- CBNumber
- CB3429480
- Molecular Formula
- C15H10O2
- Formula Weight
- 222.24
- MOL File
- 83-12-5.mol
2-PHENYL-1,3-INDANDIONE Property
- Melting point:
- 144-148 °C(lit.)
- Boiling point:
- 243.3 °C (0.3 mmHg)
- Density
- 1.1404 (rough estimate)
- refractive index
- 1.6600 (estimate)
- Flash point:
- 208 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Very slightly soluble in water; slightly soluble in ethanol (96%) and in ether. Solutions are yellow to red.
- form
- powder to crystal
- pka
- pKa 4.09(H2O,t =25,I=0.1) (Uncertain)
- color
- White to Light yellow
- Merck
- 14,7234
- CAS DataBase Reference
- 83-12-5(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- Risk Statements
- 25-43
- Safety Statements
- 36/37/39-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- NK6125000
- HS Code
- 2914.39.9000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 83-12-5(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P1029
- Product name
- 2-Phenyl-1,3-indandione
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $70
- Updated
- 2024/03/01
- Product number
- P1029
- Product name
- 2-Phenyl-1,3-indandione
- Purity
- >98.0%(GC)
- Packaging
- 250g
- Price
- $361
- Updated
- 2021/12/16
- Product number
- 30060
- Product name
- Phenindione
- Packaging
- 25mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 30060
- Product name
- Phenindione
- Packaging
- 50mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 30060
- Product name
- Phenindione
- Packaging
- 100mg
- Price
- $217
- Updated
- 2024/03/01
2-PHENYL-1,3-INDANDIONE Chemical Properties,Usage,Production
Description
Phenindione is an anticoagulant and vitamin K antagonist. It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in rat liver homogenates in a concentration-dependent manner. In vivo, phenindione (500 mg/kg) inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%, respectively. Dietary administration of phenindione (4 mg/kg per day) inhibits aortic atherosclerosis or intracardial thrombosis in rat models of diet-induced atherosclerosis or intravascular thrombosis, respectively.
Chemical Properties
light yellow fluffy fine flakes
Uses
Oral anticoagulant (indanedione).
Uses
Like coumarin derivatives, phenindione, a compound of the indandione class, acts by altering biosynthesis of coagulant proteins in the liver. It is used for preventing and treating thrombosis, thrombophlebitis, and thromboembolism. However, because of a number of side effects such as polyurea, polydipsia, tachycardia, and others, it is rarely used in practical medicine.
Definition
ChEBI: Phenindione is a beta-diketone and an aromatic ketone. It has a role as an anticoagulant. It derives from a hydride of an indane.
brand name
Hedulin (Sanofi Aventis).
Clinical Use
Anticoagulant
Synthesis
Phenindione, 3-phenylindan-1,3-dion (24.1.16), is synthesized in two ways. The first consists of condensating benzaldehyde with phthalide in the presence of sodium ethoxide. Evidently, the resulting phenylmethylenphthalide (24.1.15) rearranges under the reaction conditions to give the desired phenindione (24.1.16). The second method consists of condensation of phenylacetic acid with phthalic anhydride, forming phenylmethylenphthalide (24.1.15), which rearranges further in the presence of sodium ethoxide to phenindione.
Drug interactions
Potentially hazardous interactions with other drugs There are many significant interactions with
coumarins. Prescribe with care with regard to the
following:
Anticoagulant effect enhanced by: alcohol,
amiodarone, anabolic steroids, aspirin, aztreonam,
bicalutamide, cephalosporins, chloramphenicol,
cimetidine, ciprofloxacin, dronedarone, fibrates,
clopidogrel, cranberry juice, danazol, dipyridamole,
disulfiram, fibrates, grapefruit juice, levofloxacin,
macrolides, metronidazole, nalidixic acid, neomycin,
norfloxacin, NSAIDs, ofloxacin, paracetamol,
penicillins, ritonavir, rosuvastatin, sulphonamides,
thyroid hormones, testosterone, tetracyclines,
tigecycline, tramadol, trimethoprim.
Anticoagulant effect decreased by: oral
contraceptives, rifamycins, vitamin K.
Anticoagulant effects enhanced/reduced by: anion
exchange resins, corticosteroids, dietary changes,
enteral feeds.
Analgesics: increased risk of bleeding with IV
diclofenac and ketorolac - avoid.
Anticoagulants: increased risk of haemorrhage with
apixaban, dabigatran, edoxaban and rivaroxaban -
avoid.
Ciclosporin: there have been a few reports of altered
anticoagulant effect; decreased ciclosporin levels have
been seen rarely
Metabolism
Hepatically metabolised. Metabolites of phenindione often colour the urine pink or orange.
Purification Methods
Crystallise the dione from EtOH (m 156o) or CHCl3 (m 148-150o). [Beilstein 7 H 808, 7 III 4100, 7 IV 2570.]
2-PHENYL-1,3-INDANDIONE Preparation Products And Raw materials
Raw materials
Preparation Products
2-PHENYL-1,3-INDANDIONE Suppliers
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View Lastest Price from 2-PHENYL-1,3-INDANDIONE manufacturers
- Product
- 2-phenyl-1,3-indandione 83-12-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-11
- Product
- 2-PHENYL-1,3-INDANDIONE 83-12-5
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000KG
- Release date
- 2023-07-31