ChemicalBook > CAS DataBase List > 5-Bromo-2-fluorobenzonitrile

5-Bromo-2-fluorobenzonitrile

Product Name
5-Bromo-2-fluorobenzonitrile
CAS No.
179897-89-3
Chemical Name
5-Bromo-2-fluorobenzonitrile
Synonyms
2-Fluoro-5-bromobenzonitrile;Olapali impurity 6;Olapali impurity 17;2- fluorine-5-broMoxynil;5-BROMO-2-FLUOROBENZONITRILE;2-Flouro-5-bromobenzonitrile;2-Fliuoro-5-broMo Benzonitrile;Benzonitrile, 5-broMo-2-fluoro-;5-Bromo-2-fluorobenzonitrile98%;5-Bromo-2-fluorobenzonitrile >
CBNumber
CB3431412
Molecular Formula
C7H3BrFN
Formula Weight
200.01
MOL File
179897-89-3.mol
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5-Bromo-2-fluorobenzonitrile Property

Melting point:
76-81 °C
Boiling point:
220.4±20.0 °C(Predicted)
Density 
1.7286 (rough estimate)
refractive index 
1.5320 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
color 
White to Light yellow to Light orange
BRN 
7701063
InChI
InChI=1S/C7H3BrFN/c8-6-1-2-7(9)5(3-6)4-10/h1-3H
InChIKey
GYCNHFWRPJXTSB-UHFFFAOYSA-N
SMILES
C(#N)C1=CC(Br)=CC=C1F
CAS DataBase Reference
179897-89-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,T,Xi
Risk Statements 
36/37/38-20/21/22
Safety Statements 
36/37/39-26-22-36
RIDADR 
3439
WGK Germany 
3
Hazard Note 
Toxic
HazardClass 
6.1
PackingGroup 
III
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
465259
Product name
5-Bromo-2-fluorobenzonitrile
Purity
97%
Packaging
5g
Price
$18.72
Updated
2024/03/01
Sigma-Aldrich
Product number
465259
Product name
5-Bromo-2-fluorobenzonitrile
Purity
97%
Packaging
1g
Price
$28.6
Updated
2023/06/20
TCI Chemical
Product number
B2425
Product name
5-Bromo-2-fluorobenzonitrile
Purity
>98.0%(GC)
Packaging
5g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
B2425
Product name
5-Bromo-2-fluorobenzonitrile
Purity
>98.0%(GC)
Packaging
25g
Price
$113
Updated
2024/03/01
Alfa Aesar
Product number
A16113
Product name
5-Bromo-2-fluorobenzonitrile, 98%
Packaging
5g
Price
$44.65
Updated
2024/03/01
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5-Bromo-2-fluorobenzonitrile Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder or crystals

Uses

5-Bromo-2-fluorobenzonitrile may be used for the preparation of the following compounds:

  • (E)-5-(2-cyclopropylvinyl)-2-fluorobenzonitrile and methyl-3-amino-5-bromobenzo[b]thiophene-2-carboxylate
  • (S)-[2-[5-(3-cyano-4-fluoro-phenyl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethyl]-carbamic acid tert-butyl ester
  • 4-fluoro-3-cyano-3′-tributyltinbenzhydrol
  • 4-fluoro-3-cyano-3′-iodobenzhydrol

Synthesis

5-Bromo-2-fluorobenzonitrile is the key intermediate of the synthetic antigout drug Febuxostat. The synthesis method comprises the following steps: reacting o-fluorobenzoyl chloride with ammonia water to obtain o-fluorobenzamide; then generating o-fluorobenzonitrile under the action of a dehydration reagent; and finally, in 75-90% sulfuric acid, brominating with dibromohydantoin to obtain 5-bromo-2-fluorobenzonitrile. The synthesis method is simple and easy to implement, mild in conditions, low in production cost, and causes no wastewater discharge.

5-Bromo-2-fluorobenzonitrile Preparation Products And Raw materials

Raw materials

2-MERCAPTOPYRIMIDINE-4,6-DIOL

Preparation Products

3-Cyano-4-fluorobenzeneboronic acid
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5-Bromo-2-fluorobenzonitrile Suppliers

Americas 1 Belgium 1 China 267 Europe 4 France 1 Germany 5 India 28 Italy 1 Japan 4 Switzerland 2 United Kingdom 19 United States 49 Global 382
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View Lastest Price from 5-Bromo-2-fluorobenzonitrile manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
5-Bromo-2-fluorobenzonitrile 179897-89-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
5-Bromo-2-fluorobenzonitrile 179897-89-3
Price
US $10.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-21
PNP Biotech Co. Ltd
Product
5-Bromo-2-fluorobenzonitrile 179897-89-3
Price
US $0.00/KG
Min. Order
25KG
Purity
95%
Supply Ability
Inquiry
Release date
2022-09-22

179897-89-3, 5-Bromo-2-fluorobenzonitrileRelated Search:

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  • Benzonitrile, 5-broMo-2-fluoro-
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  • 5-BROMO-2-FLUOROBENZONITRILE
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  • 5-Bromo-2-fluorobenzonitrile 98%
  • 5-Bromo-2-fluorobenzonitrile98%
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  • 5-Bromo-2-fluorobenzonitrile (Olaparib Impurity)
  • Olapali impurity 6
  • Olapali impurity 17
  • 2-Flouro-5-bromobenzonitrile
  • 179897-89-3
  • Cyanides/Nitriles
  • Organic Building Blocks
  • Nitrogen Compounds
  • ARYL HALIDE
  • Building Blocks
  • C6 to C7
  • cyanide| alkyl bromide| alkyl Fluorine
  • Fluorine series
  • Febuxostat
  • Aromatic Nitriles
  • Nitrile
  • Miscellaneous
  • Bromine Compounds
  • Fluorine Compounds
  • Nitriles
  • C6 to C7
  • Cyanides/Nitriles
  • Nitrogen Compounds
  • Fluorobenzene