PJ-34

Product Name: PJ-34
CAS No.: 344458-19-1
Chemical Name: PJ-34
Synonyms: PJ-34;CS-856;PJ34(free base);PJ34;PJ-34;PJ 34;PJ34 PJ-34 A3729 A-3729;2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL;2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;PJ34,Inhibitor,PJ-34,PJ 34,PARP,inhibit,poly ADP ribose polymerase
CBNumber: CB3434387
Molecular Formula: C17H17N3O2
Formula Weight: 295.34
MOL File: Mol file

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PJ-34 Property

storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 045156
Product name: PJ-34
Packaging: 1mg
Price: $282
Updated: 2021/12/16

ApexBio Technology

Product number: A3729
Product name: PJ34
Packaging: 10mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-1463
Product name: PJ34
Purity: ≥98.0%
Packaging: 10mg
Price: $72
Updated: 2021/12/16

ChemScene

Product number: CS-1463
Product name: PJ34
Purity: ≥98.0%
Packaging: 50mg
Price: $204
Updated: 2021/12/16

ChemScene

Product number: CS-1463
Product name: PJ34
Purity: ≥98.0%
Packaging: 100mg
Price: $372
Updated: 2021/12/16

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PJ-34 Chemical Properties,Usage,Production

Definition

ChEBI: PJ34 is a member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, an antiatherosclerotic agent, a cardioprotective agent, an anti-inflammatory agent and a neuroprotective agent. It is a member of phenanthridines, a secondary carboxamide and a tertiary amino compound. It is a conjugate base of a PJ34(1+).

Enzyme inhibitor

This PARP inhibitor (FWfree-base = 295.34 g/mol; FWhydrochloride = 331.80 g/mol), systematically named N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)- N,N-dimethylacetamide and known for its activity in neuroprotection under stress conditions, exclusively eradicates multi-centrosomal human mammary, colon, lung, pancreas, ovarian cancer cells, by acting as an extracentrosome extracentrosome( s) de-clustering agent in mitosis. When applied at 20-30 μM, PJ-34 caused G2/M-arrest and a massive cell death Normal human proliferating endothelial, epithelial and mesenchymal cells were unaffected. PJ-34’s cytotoxicity on cancer cells is not attributable to PARP inhibition alone. PJ-34 was originally designed to protect neuronal cells in the central nervous system from cell death evoked by high activity of PARP-1 in response to DNA damage caused by brain injury, stroke or inflammation. Targets: extra-centrosome de-clustering; polyADP-ribose polymerase-1, EC50 = 20 nM

PJ-34 Preparation Products And Raw materials

Raw materials

Preparation Products

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PJ-34 Suppliers

China 49 Switzerland 1 United Kingdom 3 United States 13 Global 66

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9901
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9767
Advantage: 58

SPIRO PHARMA

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Email: eric_feng1954@126.com
Country: China
ProdList: 9254
Advantage: 55

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 3444
Advantage: 55

344458-19-1, PJ-34Related Search:

1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Bortezomib Y27632 (hydrochloride) Stattic CP-724714 Veliparib Olaparib

N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide

N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL

N-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HYDROCHLORIDE

PJ-34

PJ34(free base)

Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-

N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide PJ 34

N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide

PJ34;PJ-34;PJ 34

CS-856

2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide

2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide

PJ34 PJ-34 A3729 A-3729

PJ34,Inhibitor,PJ-34,PJ 34,PARP,inhibit,poly ADP ribose polymerase

344458-19-1

Inhibitors