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TOLYLFLUANID

Product Name
TOLYLFLUANID
CAS No.
731-27-1
Chemical Name
TOLYLFLUANID
Synonyms
B-49854;bay5212;BAY 5212;bay49854;bay5712a;EUPAREN M;ELVARON M;BAY 49854;BAY 5712a;kue13183b
CBNumber
CB3438572
Molecular Formula
C10H13Cl2FN2O2S2
Formula Weight
347.26
MOL File
731-27-1.mol
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TOLYLFLUANID Property

Melting point:
96°C
Boiling point:
93℃
Density 
1.5132 (rough estimate)
vapor pressure 
2 x 10-5 Pa (20 °C)
refractive index 
1.6000 (estimate)
storage temp. 
-20°C
solubility 
soluble in DMSO, Methanol
Colour Index 
45430
Water Solubility 
0.9 mg l-1 (20 °C)
pka
-5.06±0.50(Predicted)
BRN 
2949607
LogP
3.900
EPA Substance Registry System
Tolylfluanid (731-27-1)
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Safety

Hazard Codes 
T,N,T+
Risk Statements 
23-36/37/38-43-48/20-50/53-50-48/23-26
Safety Statements 
24-26-37-38-45-60-61-63-36/37/39-28
RIDADR 
2588
WGK Germany 
3
RTECS 
WO6560000
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
731-27-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H330Fatal if inhaled

H335May cause respiratory irritation

H372Causes damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
90619
Product name
Tolylfluanid
Purity
certified reference material, TraceCERT
Packaging
50mg
Price
$247
Updated
2024/03/01
Sigma-Aldrich
Product number
32060
Product name
Tolylfluanid
Purity
PESTANAL , analytical standard
Packaging
250mg
Price
$130
Updated
2024/03/01
TRC
Product number
T536730
Product name
Tolylfluanide
Packaging
250mg
Price
$130
Updated
2021/12/16
TRC
Product number
T536730
Product name
Tolylfluanide
Packaging
2.5g
Price
$1050
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
99614
Product name
Tolylfluanide
Packaging
2.5g
Price
$1400
Updated
2021/12/16
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TOLYLFLUANID Chemical Properties,Usage,Production

Uses

Tolylfluanid is used to control a wide range of fungal diseases on apples, grapes, strawberries and other fruit and storage diseases on many crops.

Uses

Tolylfluanid may be used as a reference standard for the determination of the analyte in nutraceutical formulations using dispersive liquid-liquid microextraction(DLLME) coupled with gas chromatography-mass spectrometry method.

Definition

ChEBI: A member of the class of sulfamides that is dichlofluanid in which the hydrogen at the para position of the phenyl group is replaced by a methyl group. A fungicide first marketed in 1971 and used in the cultivation of fruit and vegetables, as ell as in wood preservatives, it is no longer approved for use in the European Union.

Metabolic pathway

Tolylfluanid contains an unstable dichlorofluoromethylthio (sulfenyl) moiety that has been shown to undergo rapid hydrolytic and metabolic degradation to dimethylaminosulfotoluidide (2). By analogy with captan, presumably the dichlorofluoromethylthio moiety can be transferred to the sulfur atoms of cellular thiols such as cysteine and glutathione. Thus, in the presence of thiols tolylfluanid is probably cleaved at the N-S bond to form thiophosgene or its monofluoro analogue (3) and other gaseous products such as hydrogen sulfide, hydrogen chloride and carbonyl sulfide. Thiophosgene or its monofluoro analogue is rapidly hydrolysed by water. The dichlorofluoromethylthio group and thiophosgene may be intermediates in the formation of addition products, for example addition to cysteine affords thiazolidine-2-thione-4-carboxylica cid (4). A thiazolidine derivative of glutathione may also be formed. The main metabolic reactions in all media were cleavage of the N-S bond to give dimethylaminosulfotoluidide (2) followed by hydroxylation of the phenyl ring and oxidation of the methyl substituent on the phenyl ring. Glucoside conjugates were detected in plants and the cysteine adduct, thiazolidine-2- thione-4-carboxylic acid (4), was formed in rats.

Degradation

Tolylfluanid is hydrolysed rapidly in alkaline conditions. The hydrolytic DT50 is about 12 days, 29 hours and <10 minutes at pH 4,7 and 9, respectively, at 22 °C. In the environment, hydrolysis is faster than photolysis (PM; PSD, 1995). Tolylfluanid does not absorb light of wavelength >295 nm and so photodegradation is unlikely to occur in the absence of photosensitisers.

TOLYLFLUANID Preparation Products And Raw materials

Raw materials

Preparation Products

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TOLYLFLUANID Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
Shenzhen Nexconn Pharmatechs Ltd.
Tel
0755-89396905
Email
admin@nexconn.com
Country
China
ProdList
299
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4511
Advantage
55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20806
Advantage
60
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
JinJin Le Chemical Co., Ltd
Tel
10106090
Email
jjlchem2@163.com
Country
China
ProdList
9981
Advantage
58
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9353
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58

731-27-1, TOLYLFLUANIDRelated Search:


  • N,N-DIMETHYL-N'-TOLYL-N'-(DICHLOROFLUOROMETHYLTHIO) SULFAMIDE
  • TOLYFLUANID
  • TOLYLFLUANID
  • N-dichlorofluoromethylthio-N,N-dimethyl-N-p-tolylsulphamide
  • dichloro-N-[(dimethylamino)sulphonyl]fluoro-N-(p-tolyl)methanesulphenamide
  • T0LYLFLUANID, 250MG, NEAT
  • TOLYLFLUANID PESTANAL, 250 MG
  • N-Dichlorfluormethylthio-N',N'-dimethyl-N-p-tolylsulfamid
  • Tolylfluanid=Tolyfluanid
  • tolylfluanid (bsi,iso)
  • EUPARENMULTI
  • N-(dichlorofluoromethyl)thio-N',N'-dimethyl- N-(p-tolyl)-Sulfamide n-((dichlorofluoromethyl)thio)-n',n'-dimethyl-n-(p-tolyl)-sulfamid
  • tolylfluanid (ISO) dichloro-N-[(dimethylamino)sulphonyl]fluoro-N-(p-tolyl)methanesulphenamide
  • 1,1-DICHLORO-N-[(DIMETHYLAMINO)SULFONYL]-1-FLUORO-N-(4-METHYLPHENYL)METHANESULFENAMIDE
  • B-49854
  • EUPAREN M
  • EUPAREN M(R)
  • ELVARON M
  • 1,1-dichloro-n-((dimethylamino)sulfonyl)-1-fluoro-n-(4-methanesulfanenamid
  • 1,1-Dichloro-N-((dimethylamino)sulfonyl)-1-fluoro-N-(4-methylphenyl)methanesulfonamide
  • BAY 49854
  • BAY 5212
  • BAY 5712a
  • bay49854
  • bay5212
  • bay5712a
  • BAYER 49854
  • Bayer 5712a
  • bayer49854
  • N,N-Dimethyl-N'-(4-tolyl)-N'-(dichlorfluormethylthio)-sulfamid
  • N,N-Dimethyl-N-(4-tolyl)-N-(dichlorofluor-methylthio)-sulfamide
  • n,n-dimethyl-n’-(4-tolyl)-n’-(dichlorfluormethylthio)-sulfamid
  • n’-dichlorofluoromethylthio-n,n-dimethyl-n’-(4-tolyl)sulfamide
  • N'-Dichlorofluoromethylthio-N,N-dimethyl-N'-(4-tolyl)sulfamide
  • Sulfamide, N-((dichlorofluoromethyl)thio)-N',N'-dimethyl-N-(p-tolyl)-
  • Tolyfluanide
  • Tolylfluanide
  • dichloro-N-[(dimethylamino)sulphonyl]fluoro-N-(p-tolyl)methanesulphenamide,tolylfluanid (ISO)
  • bayer5712a
  • Dichlofluanid-methyl
  • KUE 13183b
  • kue13183b
  • Methanesulfanenamide, 1,1-dichloro-N-((dimethylamino)sulfonyl)-1-fluoro-N-(4-methylphenyl)-
  • Methanesulfenamide, 1,1-dichloro-N-[(dimethylamino)sulfonyl]-1-fluoro-N-(4-methylphenyl)-
  • methanesulfenamide,1,1-dichloro-n-[(dimethylamino)sulfonyl]-1-fluoro-n-(4-meth
  • n-((dichlorofluoromethyl)thio)-n’,n’-dimethyl-n-(p-tolyl)-sulfamid
  • N-([Dichloro(fluoro)methyl]sulfanyl)-N',N'-dimethyl-N-(4-methylphenyl)sulfamide
  • N-(dichlorofluoromethyl)thio-N’,N’-dimethyl-N-(p-tolyl)-Sulfamide
  • [[dichloro(fluoro)methyl]thio]-(dimethylsulfamoyl)-(4-methylphenyl)amine
  • N-[dichloro(fluoro)methyl]sulfanyl-N-(dimethylsulfamoyl)-4-methylaniline
  • N-[dichloro(fluoro)methyl]sulfanyl-N-(dimethylsulfamoyl)-4-methyl-aniline
  • Tolylfluanid 250mg [731-27-1]
  • Tolylfluanid Solution, 100ppm
  • Tolylfluanid Solution, 1000ppm
  • 1,1-Dichloro-N-((Dimethylamino)Sulfonyl)-1-Fluor
  • Tolylfluanid Standard
  • Euparen M(TM)
  • Tolylfluanide @100 μg/mL in MeOH