3-BROMO-5-CHLOROTOLUENE

Product Name: 3-BROMO-5-CHLOROTOLUENE
CAS No.: 329944-72-1
Chemical Name: 3-BROMO-5-CHLOROTOLUENE
Synonyms: 3-bromo-5-chlorotlouene;3-BROMO-5-CHLOROTOLUENE;3-Bromo-5-chlorotoluene 98%;3-Chloro-5-methyl-bromobenzene;1-BROMO-3-CHLORO-5-METHYLBENZENE;Benzene,1-bromo-3-chloro-5-methyl-
CBNumber: CB3442861
Molecular Formula: C7H6BrCl
Formula Weight: 205.48
MOL File: 329944-72-1.mol

More

Less

3-BROMO-5-CHLOROTOLUENE Property

Melting point:: 25℃
Boiling point:: 222.3±20.0℃ (760 Torr)
Density: 1.535±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 101.5±11.9℃
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Ethyl Acetate
form: Solid
color: Pale Yellow
InChI: InChI=1S/C7H6BrCl/c1-5-2-6(8)4-7(9)3-5/h2-4H,1H3
InChIKey: YRIKDGJWRMHTJP-UHFFFAOYSA-N
SMILES: C1(Br)=CC(C)=CC(Cl)=C1

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
Hazard Note: Irritant
HS Code: 2903998090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B682490
Product name: 3-Bromo-5-chlorotoluene
Packaging: 10g
Price: $130
Updated: 2021/12/16

TRC

Product number: B682490
Product name: 3-Bromo-5-chlorotoluene
Packaging: 100g
Price: $375
Updated: 2021/12/16

Apolloscientific

Product number: OR3493
Product name: 3-Bromo-5-chlorotoluene
Purity: 98%
Packaging: 5g
Price: $21
Updated: 2021/12/16

Apolloscientific

Product number: OR3493
Product name: 3-Bromo-5-chlorotoluene
Purity: 98%
Packaging: 10g
Price: $37
Updated: 2021/12/16

Matrix Scientific

Product number: 119444
Product name: 1-Bromo-3-chloro-5-methylbenzene
Purity: 95+%
Packaging: 1g
Price: $54
Updated: 2021/12/16

More

Less

3-BROMO-5-CHLOROTOLUENE Chemical Properties,Usage,Production

Uses

3-Bromo-5-chlorotoluene is a reagent used in the synthesis of novel benzophenones towards the discovery of potent, next generation HIV nonnucleoside reverse transcriptase inhibitors.

Synthesis

135340-78-2

329944-72-1

2-Bromo-6-chloro-4-methylaniline (30 mmol) was used as a starting material, which was dissolved in a mixed solution of acetic acid (60 mL), water (25 mL), and concentrated hydrochloric acid (7 mL), and the reaction system was subsequently cooled to 5 °C. A solution of sodium nitrite (48 mmol, 3.31 g) in water (12 mL) was added slowly and dropwise while keeping the temperature below 5 °C. After the dropwise addition, the reaction mixture was continued to be stirred at 5-10 °C for 2 hours. Subsequently, the reaction solution was poured into a 50% hypophosphite solution pre-cooled to 0 °C and stirred for 48 h at room temperature. Upon completion of the reaction, extraction was carried out with dichloromethane (3 x 120 mL). The organic phases were combined, washed with saturated saline (100 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. Finally, the residue was purified by fast column chromatography to obtain the target product 3-bromo-5-chlorotoluene.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 22, p. 5568 - 5572
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 12, p. 1866 - 1882
[3] Journal of Medicinal Chemistry, 2001, vol. 44, # 12, p. 1866 - 1882

3-BROMO-5-CHLOROTOLUENE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-BROMO-5-CHLOROTOLUENE Suppliers

China 109 India 3 United Kingdom 4 United States 9 Global 125

Beijing Jinrui Meixiang Technology Co., Ltd

Tel: 13691579162
Fax: QQ：480326527
Email: 480326527@qq.com
Country: China
ProdList: 497
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

329944-72-1, 3-BROMO-5-CHLOROTOLUENERelated Search:

3-BROMO-5-CHLORO-4-IODOBENZOTRIFLUORIDE brotianide 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZOIC ACID Bromochlorophenol Blue sodium salt 2-BROMO-6-CHLORO-4-(TRIFLUOROMETHYL)ANILINE 4-BROMO-2-CHLORO-6-METHYLPHENOL 3-Bromo-5-chlorosalicylaldehyde 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZAMIDE 3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE Pigment Green 36 BROMOCHLOROPHEN 4-Bromo-2-chloro-6-methylaniline 2-BROMO-5-CHLOROTOLUENE 99%,6-BROMO-3-CHLOROTOLUENE,2-BROMO-5-CHLOROTOLUENE 2-BROMO-3-CHLOROTOLUENE 2-BROMO-4-CHLOROTOLUENE 5-BROMO-2-CHLOROTOLUENE,5-BROMO-3-CHLOROTOLUENE,5-Bromo-2-chlorotoluene, 97+%,5-Bromo-2-chlorotoluene,98% 3-Chlorobenzyl bromide alpha-bromo-o-chlorotoluen

3-Bromo-5-chlorotoluene 98%

3-BROMO-5-CHLOROTOLUENE

1-BROMO-3-CHLORO-5-METHYLBENZENE

3-bromo-5-chlorotlouene

3-Chloro-5-methyl-bromobenzene

Benzene,1-bromo-3-chloro-5-methyl-

329944-72-1

blocks

Bromides