3-BROMO-5-CHLOROTOLUENE
- Product Name
- 3-BROMO-5-CHLOROTOLUENE
- CAS No.
- 329944-72-1
- Chemical Name
- 3-BROMO-5-CHLOROTOLUENE
- Synonyms
- 3-bromo-5-chlorotlouene;3-BROMO-5-CHLOROTOLUENE;3-Bromo-5-chlorotoluene 98%;3-Chloro-5-methyl-bromobenzene;1-BROMO-3-CHLORO-5-METHYLBENZENE;Benzene,1-bromo-3-chloro-5-methyl-
- CBNumber
- CB3442861
- Molecular Formula
- C7H6BrCl
- Formula Weight
- 205.48
- MOL File
- 329944-72-1.mol
3-BROMO-5-CHLOROTOLUENE Property
- Melting point:
- 25℃
- Boiling point:
- 222.3±20.0℃ (760 Torr)
- Density
- 1.535±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 101.5±11.9℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Ethyl Acetate
- form
- Solid
- color
- Pale Yellow
- InChI
- InChI=1S/C7H6BrCl/c1-5-2-6(8)4-7(9)3-5/h2-4H,1H3
- InChIKey
- YRIKDGJWRMHTJP-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC(C)=CC(Cl)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B682490
- Product name
- 3-Bromo-5-chlorotoluene
- Packaging
- 10g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- B682490
- Product name
- 3-Bromo-5-chlorotoluene
- Packaging
- 100g
- Price
- $375
- Updated
- 2021/12/16
- Product number
- FB140165
- Product name
- 1-Bromo-3-chloro-5-methylbenzene
- Packaging
- 100g
- Price
- $462
- Updated
- 2021/12/16
- Product number
- HCH0021313
- Product name
- 3-BROMO-5-CHLORO TOLUENE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $864.27
- Updated
- 2021/12/16
- Product number
- 68224
- Product name
- 3-Bromo-5-chlorotoluene
- Packaging
- 100g
- Price
- $875
- Updated
- 2021/12/16
3-BROMO-5-CHLOROTOLUENE Chemical Properties,Usage,Production
Uses
3-Bromo-5-chlorotoluene is a reagent used in the synthesis of novel benzophenones towards the discovery of potent, next generation HIV nonnucleoside reverse transcriptase inhibitors.
Synthesis
135340-78-2
329944-72-1
2-Bromo-6-chloro-4-methylaniline (30 mmol) was used as a starting material, which was dissolved in a mixed solution of acetic acid (60 mL), water (25 mL), and concentrated hydrochloric acid (7 mL), and the reaction system was subsequently cooled to 5 °C. A solution of sodium nitrite (48 mmol, 3.31 g) in water (12 mL) was added slowly and dropwise while keeping the temperature below 5 °C. After the dropwise addition, the reaction mixture was continued to be stirred at 5-10 °C for 2 hours. Subsequently, the reaction solution was poured into a 50% hypophosphite solution pre-cooled to 0 °C and stirred for 48 h at room temperature. Upon completion of the reaction, extraction was carried out with dichloromethane (3 x 120 mL). The organic phases were combined, washed with saturated saline (100 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. Finally, the residue was purified by fast column chromatography to obtain the target product 3-bromo-5-chlorotoluene.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 22, p. 5568 - 5572
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 12, p. 1866 - 1882
[3] Journal of Medicinal Chemistry, 2001, vol. 44, # 12, p. 1866 - 1882
3-BROMO-5-CHLOROTOLUENE Preparation Products And Raw materials
Raw materials
Preparation Products
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