CIS-5-BENZYL-2-BOC-HEXAHYDROPYRROLO[3,4-C]PYRROLE
- Product Name
- CIS-5-BENZYL-2-BOC-HEXAHYDROPYRROLO[3,4-C]PYRROLE
- CAS No.
- 370879-56-4
- Chemical Name
- CIS-5-BENZYL-2-BOC-HEXAHYDROPYRROLO[3,4-C]PYRROLE
- Synonyms
- CIS-5-BENZYL-2-BOC-HEXAHYDROPYRROLO[3,4-C]PYRROLE;cis-tert-Butyl 5-benzylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate;(3aR,6aS)-tert-butyl 5-benzylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate;tert-butyl (3aR,6aS)-2-benzyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate;Pyrrolo[3,4-c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-(phenylmethyl)-, 1,1-dimethylethyl ester, (3aR,6aS)-rel-
- CBNumber
- CB3449709
- Molecular Formula
- C18H26N2O2
- Formula Weight
- 302.41
- MOL File
- 370879-56-4.mol
CIS-5-BENZYL-2-BOC-HEXAHYDROPYRROLO[3,4-C]PYRROLE Property
- Boiling point:
- 393.4±35.0 °C(Predicted)
- Density
- 1.117±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 8.97±0.20(Predicted)
- Appearance
- Colorless to light yellow Liquid
N-Bromosuccinimide Price
- Product number
- FB148772
- Product name
- cis-5-Benzyl-2-boc-hexahydropyrrolo[3,4-c]pyrrole
- Packaging
- 100mg
- Price
- $197
- Updated
- 2021/12/16
- Product number
- FB148772
- Product name
- cis-5-Benzyl-2-boc-hexahydropyrrolo[3,4-c]pyrrole
- Packaging
- 25mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB148772
- Product name
- cis-5-Benzyl-2-boc-hexahydropyrrolo[3,4-c]pyrrole
- Packaging
- 50mg
- Price
- $113
- Updated
- 2021/12/16
- Product number
- FB148772
- Product name
- cis-5-Benzyl-2-boc-hexahydropyrrolo[3,4-c]pyrrole
- Packaging
- 250mg
- Price
- $395
- Updated
- 2021/12/16
- Product number
- FB148772
- Product name
- cis-5-Benzyl-2-boc-hexahydropyrrolo[3,4-c]pyrrole
- Packaging
- 500mg
- Price
- $685
- Updated
- 2021/12/16
CIS-5-BENZYL-2-BOC-HEXAHYDROPYRROLO[3,4-C]PYRROLE Chemical Properties,Usage,Production
Synthesis
172739-04-7
24424-99-5
370879-56-4
To a solution of (3aR,6aS)-2-benzyl octahydropyrrolo[3,4-c]pyrrole (10 g, 49.5 mmol) in tetrahydrofuran (THF, 100 mL) was sequentially added N,N-diisopropylethylamine (DIPEA, 12.8 g, 99 mmol) and di-tert-butyl dicarbonate (Boc2O, 10.8 g, 49.5 mmol). The reaction mixture was stirred at room temperature for 5 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed sequentially with water, saturated sodium bicarbonate (NaHCO3) solution and saturated saline. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford tert-butyl (3aR,6aS)-5-benzylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate as a yellow oil (12 g, 80%).
References
[1] Patent: WO2015/120049, 2015, A1. Location in patent: Page/Page column 139
[2] Patent: WO2016/191172, 2016, A1. Location in patent: Page/Page column 85
[3] Patent: US2002/19388, 2002, A1
[4] Patent: US2009/281118, 2009, A1. Location in patent: Page/Page column 10
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 14, p. 4126 - 4141
CIS-5-BENZYL-2-BOC-HEXAHYDROPYRROLO[3,4-C]PYRROLE Preparation Products And Raw materials
Raw materials
Preparation Products
CIS-5-BENZYL-2-BOC-HEXAHYDROPYRROLO[3,4-C]PYRROLE Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- United Kingdom
- ProdList
- 6565
- Advantage
- 38
- Tel
- --
- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74