cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole

Product Name: cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole
CAS No.: 250275-15-1
Chemical Name: cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole
Synonyms: 4-c]pyrrole;cis-2-Boc-hexahydropyrrolo;cis-2-Boc-hexahydropyrrolo[3;-Boc-hexahydropyrrolo[3,4-c]pyrrole;3-Boc-3,7-diazabicyclo[3.3.0]octane;Cis-2-Boc-hexahydropyrrol-3,4-cpyrrole;cis-3-Boc-3,7-diazabicyclo[3.3.0]octane;CIS-2-BOC-HEXAHYDROPYRROLO[3,4-C]PYRROLE;2-boc-hexahydropyrrolo[3,4-c]pyrrole, cis;cis-3,7-Diazabicyclo[3.3.0]octane, N3-BOC protected
CBNumber: CB1258602
Molecular Formula: C11H20N2O2
Formula Weight: 212.29
MOL File: 250275-15-1.mol

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cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole Property

Boiling point:: 295.4±33.0 °C(Predicted)
Density: 1.076±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 10.72±0.20(Predicted)
form: solid
color: White
InChI: InChI=1/C11H20N2O2/c1-11(2,3)15-10(14)13-6-8-4-12-5-9(8)7-13/h8-9,12H,4-7H2,1-3H3/t8-,9+
InChIKey: FYUVLZRRIRGSTE-DTORHVGOSA-N
SMILES: C(N1C[C@]2([H])CNC[C@]2([H])C1)(=O)OC(C)(C)C |&1:3,8,r|

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Safety

WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000058
Product name: meso-tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
Purity: Aldrich
Packaging: 1g
Price: $817
Updated: 2025/07/31

TRC

Product number: B656180
Product name: cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC165890
Product name: cis-2-Boc-Hexahydropyrrol[3,4-c]pyrrole
Packaging: 250mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-W001911
Product name: cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole
Purity: 98.70%
Packaging: 1g
Price: $70
Updated: 2021/12/16

Matrix Scientific

Product number: 054039
Product name: meso-tert-Butyl hexahydropyrrolo-[3,4-c]pyrrole-2(1H)-carboxylate
Packaging: 250mg
Price: $95
Updated: 2021/12/16

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cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole Chemical Properties,Usage,Production

Uses

cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole is used as a pharmaceutical intermediate in the preparation of Bicyclic pyrazole bruton's tyrosine kinase inhibitors and anticancer active ingredients. It is also used in the synthesis of other organics , such as 6-heterocycloalkyl quinazoline derivatives.

Synthesis

370879-56-4

250275-15-1

General procedure for the synthesis of tert-butyl cis-tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate from tert-butyl cis-5-benzylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate: To tert-butyl (5 g, 16.5 mmol)-5-benzylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (5 g), 16.5 mmol ) was added to a solution of 10% Pd(OH)2/C catalyst (0.5 g) in methanol (50 mL). The reaction mixture was subjected to a hydrogen atmosphere (60 psi) and stirred at 60 °C overnight and subsequently cooled to room temperature. The reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to afford tert-butyl (3R,6aS)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate as a colorless oil (2.3 g, 66% yield).

References

[1] Patent: US2002/19388, 2002, A1
[2] Patent: WO2015/120049, 2015, A1. Location in patent: Page/Page column 139; 140
[3] Patent: WO2016/191172, 2016, A1. Location in patent: Page/Page column 86
[4] Patent: US2009/281118, 2009, A1. Location in patent: Page/Page column 10
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 14, p. 4126 - 4141

cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole Preparation Products And Raw materials

Raw materials

Preparation Products

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cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole Suppliers

Canada 1 China 139 Germany 1 India 1 United Kingdom 3 United States 15 Global 160

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View Lastest Price from cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole manufacturers

Career Henan Chemical Co

Product: cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole 250275-15-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2018-08-06

250275-15-1, cis-2-Boc-hexahydropyrrolo[3,4-c]pyrroleRelated Search:

tert-Butyl bromoacetate tert-Butyl acetoacetate tert-Butyl acrylate tert-Butanol Buprofezin RESMETHRIN 2-Butoxyethanol Polyvinylpyrrolidone Pyrrole Pyrrolidine Butyl acetate N-Vinyl-2-pyrrolidone N-Methyl-2-pyrrolidone tert-Butyl acetate Povidone iodine tert-Butyl carbazate Butyl acrylate cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester

-Boc-hexahydropyrrolo[3,4-c]pyrrole

tert-butyl (3aR,6aS)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carboxylate

CIS-2-BOC-HEXAHYDROPYRROLO[3,4-C]PYRROLE

Cis-2-Boc-hexahydropyrrol-3,4-cpyrrole

cis-2-(tert-Butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrole

cis-3-Boc-3,7-diazabicyclo[3.3.0]octane

tert-Butyl (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

cis-tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

(3aR,6aS)-tert-butyl 3a,6a-diMethylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

meso-tert-Butyl hexahydropyrrolo-[3,4-c]pyrrole-2(1H)-carboxylate

cis-3,7-Diazabicyclo[3.3.0]octane, N3-BOC protected

tert-Butyl cis-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate, cis-Octahydropyrrolo[3,4-c]pyrrole, N2-BOC protected

Pyrrolo[3,4-c]pyrrole-2(1H)-carboxylicacid, hexahydro-, 1,1-diMethylethyl ester, (3aR,6aS)-rel-

(3aR,6aS)-tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

2-(tert-Butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrole

3-Boc-3,7-diazabicyclo[3.3.0]octane

tert-Butyl cis-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

tert-butyl cis-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate

CIS-tert-butyl (3aR,6aS)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carboxylate

Racemiccis-Tertbutylhexahydropyrrolo[3,4-c]Pyrrole-2(1H)-Carboxylate

2-boc-hexahydropyrrolo[3,4-c]pyrrole, cis

4-c]pyrrole

cis-2-Boc-hexahydropyrrolo[3

tert-butyl cis-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carboxylate

rel-1,1-Dimethylethyl (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

<i>meso-tert</i>-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1<i>H</i>)-carboxylate

cis-2-Boc-hexahydropyrrolo

250275-15-1

pharmacetical