PROPARGYL BENZENESULFONATE
- Product Name
- PROPARGYL BENZENESULFONATE
- CAS No.
- 6165-75-9
- Chemical Name
- PROPARGYL BENZENESULFONATE
- Synonyms
- Propargyl benzenesulfonate 96%;Acetylene sulfonate;PROPARGYL BENZENESULFOTE;Propynesulfobenzene ester;PRPARGYL BENZENESULFONATE;PROPARGYL BENZENESULFONATE;PROPARGYL BENZENESULPHONATE;2-Propynyl Benzenesulfonate;prop-2-ynyl benzenesulfonate;prop-2-ynyl benzenesulphonate
- CBNumber
- CB3453755
- Molecular Formula
- C9H8O3S
- Formula Weight
- 196.22
- MOL File
- 6165-75-9.mol
PROPARGYL BENZENESULFONATE Property
- Melting point:
- −30 °C(lit.)
- Boiling point:
- 140-142 °C2 mm Hg(lit.)
- Density
- 1.243 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.525(lit.)
- Flash point:
- 213 °F
- storage temp.
- 2-8°C
- form
- liquid
- Appearance
- Light brown to brown Liquid
- BRN
- 1107228
- InChI
- InChI=1S/C9H8O3S/c1-2-8-12-13(10,11)9-6-4-3-5-7-9/h1,3-7H,8H2
- InChIKey
- RAGBYXLIHQFIPK-UHFFFAOYSA-N
- SMILES
- C(OS(C1=CC=CC=C1)(=O)=O)C#C
- CAS DataBase Reference
- 6165-75-9(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Propyn-1-ol, 1-benzenesulfonate (6165-75-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 325341
- Product name
- Propargyl benzenesulfonate
- Purity
- 96%
- Packaging
- 100ml
- Price
- $366
- Updated
- 2025/07/31
- Product number
- P762555
- Product name
- Propargyl benzenesulfonate
- Packaging
- 100g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- P762555
- Product name
- Propargyl benzenesulfonate
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- P762555
- Product name
- Propargyl benzenesulfonate
- Packaging
- 25g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- X6174
- Product name
- Propargyl benzenesulfonate
- Packaging
- 25g
- Price
- $81
- Updated
- 2021/12/16
PROPARGYL BENZENESULFONATE Chemical Properties,Usage,Production
Uses
Propargyl Benzenesulfonate is a general chemical reagent used in organic syntheses. Used in the manufacture of Omarigliptin, a DPP-4 inhibitor used in the treatment of type-2 diabetes.
Synthesis
107-19-7
98-09-9
6165-75-9
The general procedure for the synthesis of propargylbenzenesulfonic acid from 2-propyn-1-ol and benzenesulfonyl chloride is as follows: 1.0 mol of 2-propyn-1-ol and 500 mL of methylene chloride were added to a reaction flask, and triethylamine was added as a base under stirring conditions. The reaction mixture was cooled to below 15°C and 2.1 mol of benzenesulfonyl chloride was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was allowed to gradually warm up to room temperature and stirring was continued for 1 hour. Subsequently, the reaction temperature was raised to reflux and the reaction was continued for 2 hours. The progress of the reaction was monitored by gas chromatography and after confirming the completion of the reaction, the reaction mixture was cooled in an ice bath and left to stratify. The organic layer was separated and concentrated to obtain the crude product. The crude product was purified by recrystallization to give 187.77 g of propargyl benzenesulfonic acid in pure form. The yield of the reaction was calculated to be 95.8%, the purity of the product was 99.93%, the moisture content was 28 ppm and the acid value was 36 ppm.
References
[1] Patent: CN107840812, 2018, A. Location in patent: Paragraph 0028; 0029; 0031
[2] Patent: US2340701, 1941,
[3] Justus Liebigs Annalen der Chemie, 1955, vol. 596, p. 65
[4] J. Gen. Chem. USSR (Engl. Transl.), 1963, vol. 33, p. 647 - 650
[5] Zhurnal Obshchei Khimii, 1963, vol. 33, # 2, p. 653 - 657
PROPARGYL BENZENESULFONATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PROPARGYL BENZENESULFONATE manufacturers
- Product
- Propargyl benzenesulfonate 6165-75-9
- Price
- US $99.60/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 5000kg
- Release date
- 2024-08-21
- Product
- Propargyl Benzenesulfonate 6165-75-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 1 tons
- Release date
- 2024-08-07
- Product
- Propargyl benzenesulfonate 6165-75-9
- Price
- US $10.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-12