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PROPARGYL BENZENESULFONATE

Product Name
PROPARGYL BENZENESULFONATE
CAS No.
6165-75-9
Chemical Name
PROPARGYL BENZENESULFONATE
Synonyms
Propargyl benzenesulfonate 96%;Acetylene sulfonate;PROPARGYL BENZENESULFOTE;Propynesulfobenzene ester;PRPARGYL BENZENESULFONATE;PROPARGYL BENZENESULFONATE;PROPARGYL BENZENESULPHONATE;2-Propynyl Benzenesulfonate;prop-2-ynyl benzenesulfonate;prop-2-ynyl benzenesulphonate
CBNumber
CB3453755
Molecular Formula
C9H8O3S
Formula Weight
196.22
MOL File
6165-75-9.mol
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PROPARGYL BENZENESULFONATE Property

Melting point:
−30 °C(lit.)
Boiling point:
140-142 °C2 mm Hg(lit.)
Density 
1.243 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.525(lit.)
Flash point:
213 °F
storage temp. 
2-8°C
form 
liquid
Appearance
Light brown to brown Liquid
BRN 
1107228
InChI
InChI=1S/C9H8O3S/c1-2-8-12-13(10,11)9-6-4-3-5-7-9/h1,3-7H,8H2
InChIKey
RAGBYXLIHQFIPK-UHFFFAOYSA-N
SMILES
C(OS(C1=CC=CC=C1)(=O)=O)C#C
CAS DataBase Reference
6165-75-9(CAS DataBase Reference)
EPA Substance Registry System
2-Propyn-1-ol, 1-benzenesulfonate (6165-75-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN 1760 8/PG 2
WGK Germany 
3
F 
10
HazardClass 
8
PackingGroup 
III
HS Code 
2905299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
325341
Product name
Propargyl benzenesulfonate
Purity
96%
Packaging
100ml
Price
$366
Updated
2025/07/31
TRC
Product number
P762555
Product name
Propargyl benzenesulfonate
Packaging
5g
Price
$60
Updated
2021/12/16
TRC
Product number
P762555
Product name
Propargyl benzenesulfonate
Packaging
25g
Price
$120
Updated
2021/12/16
TRC
Product number
P762555
Product name
Propargyl benzenesulfonate
Packaging
100g
Price
$385
Updated
2021/12/16
Matrix Scientific
Product number
093989
Product name
Prop-2-yn-1-yl benzenesulfonate
Purity
95+%
Packaging
10g
Price
$10
Updated
2021/12/16
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PROPARGYL BENZENESULFONATE Chemical Properties,Usage,Production

Uses

Propargyl Benzenesulfonate is a general chemical reagent used in organic syntheses. Used in the manufacture of Omarigliptin, a DPP-4 inhibitor used in the treatment of type-2 diabetes.

Synthesis

107-19-7

98-09-9

6165-75-9

The general procedure for the synthesis of propargylbenzenesulfonic acid from 2-propyn-1-ol and benzenesulfonyl chloride is as follows: 1.0 mol of 2-propyn-1-ol and 500 mL of methylene chloride were added to a reaction flask, and triethylamine was added as a base under stirring conditions. The reaction mixture was cooled to below 15°C and 2.1 mol of benzenesulfonyl chloride was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was allowed to gradually warm up to room temperature and stirring was continued for 1 hour. Subsequently, the reaction temperature was raised to reflux and the reaction was continued for 2 hours. The progress of the reaction was monitored by gas chromatography and after confirming the completion of the reaction, the reaction mixture was cooled in an ice bath and left to stratify. The organic layer was separated and concentrated to obtain the crude product. The crude product was purified by recrystallization to give 187.77 g of propargyl benzenesulfonic acid in pure form. The yield of the reaction was calculated to be 95.8%, the purity of the product was 99.93%, the moisture content was 28 ppm and the acid value was 36 ppm.

References

[1] Patent: CN107840812, 2018, A. Location in patent: Paragraph 0028; 0029; 0031
[2] Patent: US2340701, 1941,
[3] Justus Liebigs Annalen der Chemie, 1955, vol. 596, p. 65
[4] J. Gen. Chem. USSR (Engl. Transl.), 1963, vol. 33, p. 647 - 650
[5] Zhurnal Obshchei Khimii, 1963, vol. 33, # 2, p. 653 - 657

PROPARGYL BENZENESULFONATE Preparation Products And Raw materials

Raw materials

Preparation Products

Prallethrin
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PROPARGYL BENZENESULFONATE Suppliers

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View Lastest Price from PROPARGYL BENZENESULFONATE manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Propargyl benzenesulfonate 6165-75-9
Price
US $99.60/KG
Min. Order
1KG
Purity
98%
Supply Ability
5000kg
Release date
2024-08-21
Hangzhou Verychem Science And Technology Co.Ltd
Product
Propargyl Benzenesulfonate 6165-75-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
1 tons
Release date
2024-08-07
Henan Fengda Chemical Co., Ltd
Product
Propargyl benzenesulfonate 6165-75-9
Price
US $10.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-12

6165-75-9, PROPARGYL BENZENESULFONATERelated Search:

Propargyl Benzenesulfonate-13C6 N-PROPYLBENZENE 2-Butynyl 4-methylbenzenesulfonate P-TOLUENESULFONIC ACID 1-BUTYN-3-YL ESTER AURORA KA-717 hexa-2,4-diyne-1,6-diyl bis(4-methylbenzenesulphonate) PROPARGYL P-TOLUENESULFONATE PROPARGYL BENZENESULFONATE AKOS 213-197

  • Propargyl benzenesulfonate 96%
  • Prop-2-yn-1-yl benzenesulfonate
  • PROPARGYL BENZENESULFOTE
  • PROPARGYL BENZENESULFONATE
  • PROPARGYL BENZENESULPHONATE
  • prop-2-ynyl benzenesulphonate
  • Benzenesulfonic acid 2-propynyl ester
  • prop-2-ynyl benzenesulfonate
  • Propargylbenzenesulfonate,95%
  • Propynesulfobenzene ester
  • 2-propyn-1-yl benzenesulfonate
  • BENZENESULFONIC ACID PROPARGYL ESTER PROPARGYL
  • 2-Propyn-1-ol, 1-benzenesulfonate
  • 2-Propynyl Benzenesulfonate
  • Propargyl BezensulfonateQ: What is Propargyl Bezensulfonate Q: What is the CAS Number of Propargyl Bezensulfonate Q: What is the storage condition of Propargyl Bezensulfonate Q: What are the applications of Propargyl Bezensulfonate
  • Acetylene sulfonate
  • PRPARGYL BENZENESULFONATE
  • Propargylbenzenesulfonic acid
  • 6165-75-9
  • 6164-75-9
  • 165-75-9
  • C9H8O3S
  • C6H5SO3CH2C8801CH
  • C6H5SO3CH2CCH
  • Building Blocks
  • Sulfonates/Sulfinates
  • Sulfur Compounds
  • Organic Building Blocks
  • Organic Building Blocks
  • Sulfonates/Sulfinates
  • Sulfur Compounds