4-Chloro-2-(trifluoromethyl)benzonitrile
Application- Product Name
- 4-Chloro-2-(trifluoromethyl)benzonitrile
- CAS No.
- 320-41-2
- Chemical Name
- 4-Chloro-2-(trifluoromethyl)benzonitrile
- Synonyms
- oro-2-(trifL;3-Chloro-6-cyanobenzotrifluoride;5-CHLORO-2-CYANOBENZOTRIFLUORIDE;5-Chloro-2-cyanobenzotrifluoride98%;5-Chloro-2-cyanobenzotrifluoride 98%;2-TRIFLUOROMETHYL-4-CHLOROBENZONITRILE;4-CHLORO-2-(TRIFLUOROMETHYL)BENZONITRILE;4-chloro-2-(trifluoronethyl)benzonitrile;Benzonitrile, 4-chloro-2-(trifluoromethyl)-;4-Chloro-2-(trifluoromethyl)benzonitrile 98%
- CBNumber
- CB3454545
- Molecular Formula
- C8H3ClF3N
- Formula Weight
- 205.56
- MOL File
- 320-41-2.mol
4-Chloro-2-(trifluoromethyl)benzonitrile Property
- Boiling point:
- 109/10mm
- Density
- 1.43±0.1 g/cm3(Predicted)
- refractive index
- 1.4950
- storage temp.
- 2-8°C
- CAS DataBase Reference
- 320-41-2(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- RIDADR
- UN3276
- Hazard Note
- Toxic
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C598240
- Product name
- 4-Chloro-2-(trifluoromethyl)benzonitrile
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3837-7-42
- Product name
- 5-Chloro-2-cyanobenzotrifluoride
- Purity
- 97%
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3837-7-42
- Product name
- 5-Chloro-2-cyanobenzotrifluoride
- Purity
- 97%
- Packaging
- 5G
- Price
- $95
- Updated
- 2021/12/16
- Product number
- HCH0023305
- Product name
- 4-CHLORO-2-(TRIFLUOROMETHYL)BENZONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $629.48
- Updated
- 2021/12/16
- Product number
- 116561
- Product name
- 4-Chloro-2-(trifluoromethyl)benzonitrile
- Packaging
- 5g
- Price
- $203
- Updated
- 2021/12/16
4-Chloro-2-(trifluoromethyl)benzonitrile Chemical Properties,Usage,Production
Application
4-Chloro-2-trifluoromethylbenzonitrile (1) is an important intermediate in the synthesis of bicalutamide. In addition, due to its multiple reaction sites, it is widely used in the preparation of pharmaceutical and chemical intermediates.
Chemical Properties
Yellow liquid
Synthesis
23399-77-1
557-21-1
320-41-2
General procedure for the synthesis of 2-trifluoromethyl-4-chlorobenzonitrile from 2-iodo-5-chlorobenzotrifluoride and zinc cyanide: 4-chloro-1-iodo-2-trifluoromethylbenzene (1500 mg, 4.89 mmol), zinc cyanide (345 mg, 2.94 mmol) and tetrakis(triphenylphosphine)palladium(0) (564 mg, 0.488 mmol), then N,N-dimethylformamide (40 mL) was added. The reaction mixture was heated at 80 °C for overnight reaction. After the reaction was completed, it was cooled to room temperature, the reaction solution was diluted with toluene, washed sequentially with 2N ammonium hydroxide solution (3 times) and saturated aqueous sodium chloride solution, and the organic phase was filtered after drying and concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography with hexane/dichloromethane as eluent to give 4-chloro-2-trifluoromethylbenzonitrile (630 mg, 63% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.81-7.78 (m, 2H), 7.67 (dd, 1H, J = 8.4, 2.4 Hz).
References
[1] Patent: WO2006/44454, 2006, A1. Location in patent: Page/Page column 63
4-Chloro-2-(trifluoromethyl)benzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-2-(trifluoromethyl)benzonitrile Suppliers
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- info@pschemicals.com
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- The Netherlands
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View Lastest Price from 4-Chloro-2-(trifluoromethyl)benzonitrile manufacturers
- Product
- 4-Chloro-2-(trifluoromethyl)benzonitrile 320-41-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-12
- Product
- 4-Chloro-2-(trifluoromethyl)benzonitrile 320-41-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-05-21
- Product
- 4-Chloro-2-(trifluoromethyl)benzonitrile 320-41-2
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-08