3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide

Product Name: 3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide
CAS No.: 26723-60-4
Chemical Name: 3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide
Synonyms: 3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol;3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-...;3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-ol;3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide;3-CHLORO-6,11-DIHYDRO-5,5-DIOXO-11-HYDROXY-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE;Dibenzo[c,f][1,2]thiazepin-11-ol, 3-chloro-6,11-dihydro-6-methyl-, 5,5-dioxide;3-Chloro-6,11-dihydro-6-methyl-11-hydroxydibenzo[c,f][1,2]thiazepine 5,5-dioxide;3-Chloro-11-hydroxy-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide
CBNumber: CB3455067
Molecular Formula: C14H12ClNO3S
Formula Weight: 309.77
MOL File: 26723-60-4.mol

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3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide Property

Melting point:: 196-198°C
Boiling point:: 482.8±55.0 °C(Predicted)
Density: 1.472±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 12.60±0.20(Predicted)
color: White
Water Solubility: 30mg/L at 25℃
LogP: 2.78

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C374795
Product name: 3-Chloro-6,11-dihydro-5,5-dioxo-11-hydroxy-6-methyldibenzo[c,f][1,2]thiazepine
Packaging: 100mg
Price: $1110
Updated: 2021/12/16

AK Scientific

Product number: X0078
Product name: 3-Chloro-6,11-dihydro-5,5-dioxo-11-hydroxy-6-methyldibenzo[c,f][1,2]thiazepine
Packaging: 100g
Price: $1190
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0027747
Product name: 3-CHLORO-6,11-DIHYDRO-5,5-DIOXO-11-HYDROXY-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE
Purity: 95.00%
Packaging: 10G
Price: $1531.53
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC140279
Product name: 3-Chloro-6,11-dihydro-5,5-dioxo-11-hydroxy-6-methyldibenzo[c,f][1,2]thiazepine
Packaging: 10g
Price: $161.3
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC140279
Product name: 3-Chloro-6,11-dihydro-5,5-dioxo-11-hydroxy-6-methyldibenzo[c,f][1,2]thiazepine
Packaging: 5G
Price: $93
Updated: 2021/12/16

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3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide Chemical Properties,Usage,Production

Uses

3-Chloro-6,11-dihydro-5,5-dioxo-11-hydroxy-6-methyldibenzo[c,f][1,2]thiazepine, can beused in the synthesis of Dibenzo[c,f][1,2]thiazepine derivatives.

Synthesis

26638-53-9

26723-60-4

The general procedure for the synthesis of 3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin-11(6H)-one 5,5-dioxide from 3-chloro-6-methyl-dibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide was as follows: to a solution of 3-chloro-6-methyl-dibenzo[c,f][1,2]thiazepin- 11(6H)-one 5,5-dioxide (62.5 g) to a solution of methanol (500 ml), sodium borohydride (15.04 g) was slowly added at 0-5 °C. The reaction mixture was stirred at 0-5 °C for 30 min, followed by continued stirring at room temperature for 30-60 min. After completion of the reaction, the solid product was collected by filtration and washed with methanol. The resulting solid was dried under constant weight to afford 3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide in 90-95% yield.

References

[1] Patent: WO2010/70667, 2010, A2. Location in patent: Page/Page column 5
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 13, p. 2481 - 2496

3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide Suppliers

China 61 Europe 1 Germany 2 India 1 United Kingdom 2 United States 11 Global 78

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Hangzhou Molcore Biopharmatech Co.,Ltd

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View Lastest Price from 3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide manufacturers

Career Henan Chemical Co

Product: 3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-ol 26723-60-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

26723-60-4, 3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxideRelated Search:

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3-CHLORO-6,11-DIHYDRO-5,5-DIOXO-11-HYDROXY-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE

3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide

3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol

3-Chloro-11-hydroxy-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide

3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-ol

3-Chloro-6,11-dihydro-6-methyl-11-hydroxydibenzo[c,f][1,2]thiazepine 5,5-dioxide

Dibenzo[c,f][1,2]thiazepin-11-ol, 3-chloro-6,11-dihydro-6-methyl-, 5,5-dioxide

3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-...

26723-60-4

26623-60-4

C14H12CINO3S