7-AVCA

Product Name: 7-AVCA
CAS No.: 79349-82-9
Chemical Name: 7-AVCA
Synonyms: 7-AMINO-3-VINYLCEPHALOSPORANIC ACID;(6R,7R)-7-AMino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;7-AVCA/(6R,7R)-7-AMino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;7-AVCA;Cefixime Impurity 8;Cefdinir Impurity 30;Cefixime Inermediates;Cefdinir CP Impurity C;Cefdinir Impurity C(CP);Cefixime Impurity 7 AVCA
CBNumber: CB3457874
Molecular Formula: C9H10N2O3S
Formula Weight: 226.25
MOL File: 79349-82-9.mol

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7-AVCA Property

Melting point:: 215-220°C
Boiling point:: 540.7±50.0 °C(Predicted)
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: Aqueous Base (Slightly), DMSO (Slightly)
form: Solid
pka: 2.73±0.50(Predicted)
color: White to Pale Yellow
InChI: InChI=1S/C9H10N2O3S/c1-2-4-3-15-8-5(10)7(12)11(8)6(4)9(13)14/h2,5,8H,1,3,10H2,(H,13,14)/t5-,8-/m1/s1
InChIKey: GQLGFBRMCCVQLU-SVGQVSJJSA-N
SMILES: N12[C@@]([H])([C@H](N)C1=O)SCC(C=C)=C2C(O)=O
CAS DataBase Reference: 79349-82-9(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A632600
Product name: 7-Amino-3-vinyl-3-cephem-4-carboxylicAcid
Packaging: 100mg
Price: $105
Updated: 2021/12/16

AK Scientific

Product number: J20661
Product name: 7-AVCA
Packaging: 1g
Price: $98
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17544
Product name: 7-Amino-3-vinyl-3-cephem-4-carboxylic acid
Packaging: 2g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17544
Product name: 7-Amino-3-vinyl-3-cephem-4-carboxylic acid
Packaging: 1g
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17544
Product name: 7-Amino-3-vinyl-3-cephem-4-carboxylic acid
Packaging: 5G
Price: $150
Updated: 2021/12/16

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7-AVCA Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A key intermediate in the manufacturing of Cephalosporin compounds.

Synthesis

33748-00-4

79349-82-9

The general procedure for the synthesis of (6R,7R)-7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid from cefixime impurity is as follows: 25.5 g (0.05 mol) of GVNA was placed in a 1,000 mL three-necked flask fitted with a thermometer and a mechanical stirrer, and 300 g of phenol and 2.8 g of acetic acid and the reaction was held at 35°C. After the reaction was complete (about 6 hours), the reaction mixture was slowly poured into a mixed solution consisting of sodium bicarbonate, purified water, and butyl acetate (5 g of purified water, 200 mL of purified water, and 200 mL of butyl acetate). The aqueous phase was extracted twice with 50 mL of butyl acetate and the aqueous phases were combined. The aqueous phase was transferred to a 500 mL reaction flask and stirred at room temperature for 2 hours. 4 g of immobilized acyltransferase PGA-450 was added, followed by dropwise addition of 15% aqueous sodium carbonate solution, maintaining the pH between 8.0-8.2 until the HPLC assay showed less than 0.5% GVNA. The enzyme was recovered by filtration. The filtrate was collected and the pH was adjusted with 10% hydrochloric acid to 3.4. The filter cake was washed with 50 mL of acetone and dried to give 10.7 g of AVNA (93.8% yield as GVNA).

References

[1] Patent: CN104045655, 2016, B. Location in patent: Paragraph 0061
[2] Organic Process Research and Development, 2009, vol. 13, # 5, p. 924 - 927
[3] Patent: CN103923104, 2016, B. Location in patent: Paragraph 0032-0034

7-AVCA Preparation Products And Raw materials

Raw materials

Preparation Products

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7-AVCA Suppliers

Canada 1 China 233 Germany 2 India 8 Japan 1 Ukraine 1 United Kingdom 6 United States 19 Global 271

Nanjing XiLang Chemical Products Co., Ltd.

Tel: 18936048580
Email: chemxilang@163.com
Country: China
ProdList: 3909
Advantage: 58

Wuhan Wiseman Bioengineering Co.,Ltd

Tel: 13419526507 13419526507
Fax: 027-59506022
Email: 13419526507@163.com
Country: China
ProdList: 2845
Advantage: 58

Shanghai Peiling Biological Technology Co., Ltd

Tel: 13127581762
Email: peilingchem@sina.com
Country: China
ProdList: 479
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

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View Lastest Price from 7-AVCA manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 7-AVCA 79349-82-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-08-21

Guangzhou Tosun Pharmaceutical Ltd

Product: Cefdinir Impurity C 79349-82-9
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 95%+
Supply Ability: 1000mg
Release date: 2025-02-12

Guangzhou Tosun Pharmaceutical Ltd

Product: Cefixime Impurity 8
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 95%+
Supply Ability: 1000mg
Release date: 2024-12-20

79349-82-9, 7-AVCARelated Search:

N-Vinyl-2-pyrrolidone Triethoxyvinylsilane 4-(4-CHLORO-BENZYLOXY)-PHENYLAMINE VINYL PROPIONATE (6R-trans)-7-[[(2-AMino-4-thiazolyl)acetyl]aMino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid (6R,7R)-7-((Z)-2-(2-aMinothiazol-4-yl)-2-(hydroxyiMino)acetaMido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-oxide (Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamide (Z)-Cefdinir Cefdinir Impurity E H-D-PHG-OME HCL 3-Hydroxy-4-Methyl-2(5H)-thiophenone Cefdinir Impurity M Phenylglycylcefalexin (6R,7R)-7-(4-Hydroxyisoxazole-3-carboxaMido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid D(-)-Phenylglycinamide Cefdinir Impurity N (6R-trans)-7-[(2,2-diMethyl-1-oxopropyl)aMino]-3-Methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-

(6R,7R)-7-AMino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-AVCA/(6R,7R)-7-AMino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-AVCA-DIMER(CEFDINIR MOTHER NUCLEUS DIMER )

Cefdinir impurity 3/Cefdinir CP Impurity C/(6S,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-oxide

(6R,7R)-7-Amino-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-AVCA

7-AMINO 3-VINYL-3-CEPHEM-4-CARBOXYLIC ACID

7-AMINO-3-VINYL-3-CEPHEM-4-CARBOXYLIC ACID(7-AVCA)

7-AMINO-3-VINYLCEPHALOSPORANIC ACID

(6R-Trans)-7-amino-8-oxo-3-ethenyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-amino-3-ethenyl-8-oxo-,(6R,7R)-

7-amino-3-ethenyl-8-oxo-, (6R,7R)-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R-trans)-7-AMino-3-ethenyl-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

Cefixime Impurity 8

Cefdinir Impurity C(CP)

7-Amino-3-vinyla-3-cephem-4-carboxylic acid

Cefdinir Impurity 30

Cefixime Impurity 7 AVCA

Cefdinir Impurity C: (6R,7R)-7-Amino-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid(7-AVCA)

(6R,7R)-7-amino-8-oxo-3-vinyl-

7-amino-3-vinyl-3-cephem-4-carboxylic aid

Cefdinir Impurity 30 (Cefdinir CP Impurity C)

7-AVCA 7-Amino-3-Vinyl-3-Cephem-4-Carboxylic Acid

7-AVCA Cefdinir Impurity C(CP)

7-amino-3-vinyl-3-cephalocyph-4-carboxylic acid

Cefixime Impurity 8（Cefdinir CP Impurity C）

7-Amino-3-vinyl-3-cephem-4-carboxylicAci

7-AVCA (Cefdinir Impurity C)

Cefdinir CP Impurity C

Cefixime Inermediates

(6R,7R)-7-Amino-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid

79349-82-9

Organic acids

Amines

Chiral Reagents

Intermediates & Fine Chemicals

Pharmaceuticals