ChemicalBook > CAS DataBase List > Isoxepac

Isoxepac

Product Name
Isoxepac
CAS No.
55453-87-7
Chemical Name
Isoxepac
Synonyms
2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid;Olapatadine;6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETIC ACID;6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid;hp549;artil;ND4-B2;P-720549;isoxepac;NSC 300907
CBNumber
CB3466254
Molecular Formula
C16H12O4
Formula Weight
268.26
MOL File
55453-87-7.mol
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Isoxepac Property

Melting point:
130-132°C
Boiling point:
528.2±50.0 °C(Predicted)
Density 
1.39 g/cm3
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
4.24±0.10(Predicted)
color 
White to Light yellow to Light orange
Merck 
14,5237
InChIKey
QFGMXJOBTNZHEL-UHFFFAOYSA-N
CAS DataBase Reference
55453-87-7(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25-62
Safety Statements 
36/37-45
RIDADR 
UN 2811 6.1 / PGIII
RTECS 
HQ4110000
HazardClass 
6.1
PackingGroup 
III
HS Code 
2932996560
Toxicity
LD50 orally in rats: 199 mg/kg (Ueno)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2539
Product name
Olopatadine Related Compound C
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50MG
Price
$534
Updated
2024/03/01
Sigma-Aldrich
Product number
1478436
Product name
Olopatadine Related Compound C
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
35mg
Price
$1380
Updated
2024/03/01
TCI Chemical
Product number
D4242
Product name
6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$60
Updated
2024/03/01
TCI Chemical
Product number
D4242
Product name
6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$209
Updated
2024/03/01
TRC
Product number
I917700
Product name
Isoxepac
Packaging
10g
Price
$305
Updated
2021/12/16
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Isoxepac Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

Isoxepac is a non-steroidal anti-inflammatory with analgesic and antipyretic activity. It is more slowly absorbed and eliminated in the rat and rabbit after oral dosing than in the dog, rhesus monkey and man.It can be used to treat allergic rhinitis, urticaria, and skin diseases with itching symptoms.

Definition

ChEBI: Isoxepac is a dibenzooxazepine.

Preparation

Isoxic acid is an important intermediate in the synthesis of the new preferred anti-allergic drug, olopatadine hydrochloride, preparation method of isoxepac:
(1) condensation: prepare p-hydroxyphenylaceticacid 8-12 part, phthalide 6-12 part, sodium methylate 8-12 part by weight; Dissolve with DMAC and to add said sodium methylate behind said p-hydroxyphenylaceticacid and the phthalide; Be that 0.1-10Pa is heated to 80-170 ℃ of reaction 3-10h at pressure then; Regulate the pH value to 1-5,4-(2-carboxyl benzyloxy) toluylic acid is separated out in crystallization;
(2) cyclization: with Glacial acetic acid min. 99.5 dissolving step (1) gained 4-(2-carboxyl benzyloxy) toluylic acid, adding 3-52 weight part polyphosphoric acid again, is that 0.1-10Pa is heated to 30-100 ℃ of reaction 3-12h at pressure, and crystallisation by cooling gets the Isoxepac bullion then;
(3) purify: behind the said Isoxepac bullion of acetic acid ethyl dissolution, refining decolouring gets the Isoxepac product.
https://patents.google.com/patent/CN102838582A/en

brand name

Artil(Hoechst-Roussel) .

Isoxepac Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Isoxepac manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Isoxepac 55453-87-7
Price
US $40.00-40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-19
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Isoxepac 55453-87-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%min
Supply Ability
1000kg
Release date
2021-07-01
Hebei Mojin Biotechnology Co., Ltd
Product
Isoxepac 55453-87-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-26

55453-87-7, IsoxepacRelated Search:

Phenoxyacetic acid Ethyl 2-(Chlorosulfonyl)acetate Allyl phenoxyacetate 2-Hydroxyphenylacetic acid Triclopyr Fluroxypyr Dihydromyrcenol 4-Hydroxyphenylacetic acid Ethyl phenylacetate IXABEPILONE Ascoric Acid Olopatadine hydrochloride Olopatadine-d3 N-Oxide Olopatadine USP RC B Olopatadine Isopropyl ester Hydrochloride Olopatadine N-Oxide Olopatadine Impurity 1 edoxaban

  • Olopatadine Impurity 3（Olopatadine USP RC C）
  • 6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic acid, 97.0%
  • e)oxepin-2-aceticacid,6,11-dihydro-11-oxo-dibenz(
  • hp549
  • DIBENZ[B,E]OXEPIN-2-ACETIC ACID, 6,11-DIOHYDRO-11-OXO
  • 6,11-Hydro-11-Oxo-Dibenz[B,E]Oxepin-2-Acetic Acid
  • Olapatadine
  • 11-Oxo-6,11-Dihydrobenz(b,e)oxepin-2-Acetic Acid (Isoxepac)
  • Isoxepac (Dibenz[b,e]oxepin-2-acetic acid, 6,11-dihydro-11-oxo)
  • 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic
  • 2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid
  • 6,11-Dihydro-11-oxodibenz[b,e]oxepine-2-acetic acid
  • P-720549
  • 6,11-dihydro-11-oxodibenz[b,e]opepin-2-acetic acid
  • 2-(11-keto-6H-benzo[c][2]benzoxepin-2-yl)acetic acid
  • 2-(11-oxo-6H-benzo[c][2]benzoxepin-2-yl)acetic acid
  • 2-(11-oxo-6H-benzo[c][2]benzoxepin-2-yl)ethanoic acid
  • 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid (Isoxepac)
  • 6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETIC ACID(FOR OLOPATADINE)
  • 6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic acid (Olopatadine)
  • Olopatadine Related Compound C (35 mg) ((11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid)
  • ND4-B2
  • artil
  • isoxepac
  • 6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETIC ACID
  • (11-OXO-6,11-DIHYDRODIBENZO[B,E]OXEPIN-2-YL)ACETIC ACID
  • Olotatadine related compound C
  • 11-Oxo-6,11-dihydrodibenz[b,e]oxepin-2-acetic Acid
  • NSC 300907
  • Isoxepac-d6
  • 6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid
  • Olopatadine Related CoMpund C
  • Olopatadine Related CoMpound C
  • Olopatadine USP RC C
  • Olopatadine USP Related Compound C
  • e]oxepin-2-acetic acid
  • 11-Dihydro-11-oxo-dibenz[b
  • 6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-aceticAcid&gt
  • Dibenz[b,e]oxepin-2-acetic acid, 6,11-dihydro-11-oxo-
  • Olopatadine Related Compound C (35 mg)
  • 6H-11-Oxodibenzo[b,e]oxepin-2-acetic Acid
  • TIANFU-CHEM 55453-87-7 Isoxepac
  • Olopatadine Related Compound C ((11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid) (1478436)
  • 16-trihydroxy-palmitic acid
  • Isoxepac-HBW
  • Olotadine Hydrochloride Isoclate
  • (11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic Acid (Isoxepac)
  • Isoxic acid
  • 2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)aceticaci
  • OLOPATADINE EP IMP C
  • 6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid or Isopec
  • 55453-87-7
  • 1313-91-1
  • 55453-67-7
  • C16H12O4
  • API
  • Pharmaceutical intermediate
  • APIs Intermediate