ChemicalBook > CAS DataBase List > TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

Product Name
TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
CAS No.
156185-63-6
Chemical Name
TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
Synonyms
Boc-4-piperidinepropanol;N-Boc-4-piperidinepropanol;3-(1-Boc-4-piperidyl)-1-propanol;3-(N-Boc-piperidin-4-yl)propanol;N-BOC-4-(3'-propanol)-piperidine;1-N-BOC-4-(3'-PROPANOL)-PIPERIDINE;N-Boc-4-(3-Hydroxypropyl)piperidine;4-(3-Hydroxypropyl)piperidine, N-BOC protected;3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanol;4-(3-Hydroxyprop-1-yl)piperidine, N-BOC protected
CBNumber
CB3466926
Molecular Formula
C13H25NO3
Formula Weight
243.34
MOL File
156185-63-6.mol
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TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Property

Boiling point:
339.8±15.0 °C(Predicted)
Density 
1.029
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
15.16±0.10(Predicted)
form 
Low-Melting Solid
color 
White to Off-White
InChI
InChI=1S/C13H25NO3/c1-13(2,3)17-12(16)14-8-6-11(7-9-14)5-4-10-15/h11,15H,4-10H2,1-3H3
InChIKey
OXPWHPCCUXESFQ-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(CCCO)CC1
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
Hazard Note 
Irritant
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B694715
Product name
tert-Butyl4-(3-Hydroxypropyl)piperidine-1-carboxylate
Packaging
1g
Price
$180
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-D7
Product name
4-(3-Hydroxypropyl)piperidine, N-Boc protected
Packaging
1g
Price
$247
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-D7
Product name
4-(3-Hydroxypropyl)piperidine, N-Boc protected
Packaging
250mg
Price
$87
Updated
2021/12/16
Matrix Scientific
Product number
085607
Product name
tert-Butyl 4-(3-hydroxypropyl)tetrahydro-1(2H)-pyridinecarboxylate
Purity
95%
Packaging
1g
Price
$377
Updated
2021/12/16
AK Scientific
Product number
J98576
Product name
1-N-Boc-4-(3'-propanol)-piperdine
Packaging
10g
Price
$340
Updated
2021/12/16
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TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Chemical Properties,Usage,Production

Uses

tert-Butyl 4-(3-Hydroxypropyl)piperidine-1-carboxylate is a reagent in the preparation of 1-alkyloxy-2-methoxy-4-nitrobenzene fragments: potent human glutaminyl cyclase inhibitors.

Synthesis

7037-49-2

24424-99-5

156185-63-6

The general procedure for the synthesis of N-BOC-4-(3'-hydroxypropyl)-piperidine from 3-(4-piperidinyl)-1-propanol and di-tert-butyl dicarbonate was as follows: 1. Di-tert-butyl dicarbonate (3.66 g, 16.8 mmol) was slowly added to a stirring solution of anhydrous dichloromethane (20 mL) of 3-(4-piperidinyl)-1-propanol (1.60 g, 11.2 mmol) under nitrogen protection and the reaction was carried out at ambient temperature. 2. The resulting reaction mixture was stirred continuously for 2 hours. 3. Upon completion of the reaction, the mixture was purified directly by silica gel column chromatography with the eluent being methanol in dichloromethane (0-3% gradient). 4. The target fraction was collected to afford N-BOC-4-(3'-hydroxypropyl)-piperidine as a clear oil (2.40 g, 88% yield).

References

[1] Organic Letters, 2002, vol. 4, # 4, p. 549 - 552
[2] Patent: US2008/306082, 2008, A1. Location in patent: Page/Page column 5-6
[3] Patent: US6235731, 2001, B1
[4] Organic and Biomolecular Chemistry, 2014, vol. 12, # 5, p. 783 - 794
[5] Tetrahedron, 1999, vol. 55, # 39, p. 11619 - 11639

TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Suppliers

Belgium 1 China 93 Germany 2 India 1 United Kingdom 6 United States 19 Global 122
Service Chemical Inc.
Tel
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Fax
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Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
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View Lastest Price from TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE manufacturers

Career Henan Chemical Co
Product
TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 156185-63-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-14

156185-63-6, TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATERelated Search:

TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE piperidine-4-propanol METHYL N-BOC-4-PIPERIDINEPROPIONATE 4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-Boc-4-piperidinepropionic acid TERT-BUTYL FORMATE N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL ETHYL 3-(1-BOC-PIPERIDINE-4-YL)-DL-BETA-ALANINATE N-ALPHA-FMOC-BETA-(1-BOC-PIPERIDIN-4-YL)-D,L-ALANINE 4'-N-BOC-SPIRO-INDANE-PIPERIDINE-3-CARBOXYLIC ACID 4-[2-CARBOXY-1-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ETHYL]-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(2-ETHOXYCARBONYL-1-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERTIO-BUTYL ESTER (S)-N-ALPHA-N'-DI-T-BUTYLOXYCARBONYL-4-PIPERIDYLALANINE L-ALA-4PIP(BOC)-OME BOC-(3S, 3R)-3-AMINO-[3-(4-PIP(BOC))]PROPIONIC ACID 4-(1-BENZYLOXYCARBONYLAMINO-2-CARBOXY-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 2-(1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)CYCLOHEXANECARBOXYLIC ACID 4-(1-AMINO-2-CARBOXY-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

  • 4-(3-HYDROXY-PROPYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 1-N-BOC-4-(3'-PROPANOL)-PIPERIDINE
  • 4-(3-Hydroxypropyl)piperidine, N-BOC protected
  • TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
  • Tert-butyl 4-(3-hydroxypropyl)tetrahydro-1(2H)-pyridinecarboxylate ,97%
  • 3-(1-Boc-4-piperidyl)-1-propanol
  • 3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanol
  • 3-(N-Boc-piperidin-4-yl)propanol
  • tert-Butyl 4-(3-hydroxypropyl)tetrahydropyridine-1(2H)-carboxylate
  • 1-Piperidinecarboxylic acid, 4-(3-hydroxypropyl)-, 1,1-diMethylethyl ester
  • N-Boc-4-(3-Hydroxypropyl)piperidine
  • 4-(3-Hydroxyprop-1-yl)piperidine, N-BOC protected
  • tert-Butyl 4-(3-hydroxyprop-1-yl)piperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(3-hydroxyprop-1-yl)piperidine
  • N-BOC-4-(3'-propanol)-piperidine
  • Boc-4-piperidinepropanol
  • N-Boc-4-piperidinepropanol
  • 1-N-Boc-4-(3′-propanol)-piperdine, CAS 156185-63-6
  • 156185-63-6
  • C13H25NO3
  • Pyrans, Piperidines &Piperazines
  • Pyrans, Piperidines & Piperazines
  • CMLLYL