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piperidine-4-propanol

Product Name
piperidine-4-propanol
CAS No.
7037-49-2
Chemical Name
piperidine-4-propanol
Synonyms
Einecs 230-318-7;4-piperidinepropanol;4-piperidinopropanol;piperidine-4-propanol;4-Piperidine-1-propanol;3-Piperidin-4-propan-1-ol;3-(4-Piperidinyl)propanol;3-(4-Piperidyl)-1-propanol;4-(3-Hydroxypropy)piperidine;3-(4-Piperidinyl)-1-propanol
CBNumber
CB3919129
Molecular Formula
C8H17NO
Formula Weight
143.23
MOL File
7037-49-2.mol
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piperidine-4-propanol Property

Melting point:
65 °C
Boiling point:
235℃
Density 
0.929
Flash point:
90℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
15.16±0.10(Predicted)
Appearance
White to light yellow Solid
InChI
InChI=1S/C8H17NO/c10-7-1-2-8-3-5-9-6-4-8/h8-10H,1-7H2
InChIKey
DBIMLJDSPUCGGY-UHFFFAOYSA-N
SMILES
N1CCC(CCCO)CC1
EPA Substance Registry System
4-Piperidinepropanol (7037-49-2)
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
H952655
Product name
4-(3-Hydroxypropyl)piperidine
Packaging
50mg
Price
$165
Updated
2021/12/16
Matrix Scientific
Product number
020666
Product name
3-Piperidin-4-yl-propan-1-ol
Purity
95+%
Packaging
500mg
Price
$27
Updated
2021/12/16
Matrix Scientific
Product number
020666
Product name
3-Piperidin-4-yl-propan-1-ol
Purity
95+%
Packaging
1g
Price
$44
Updated
2021/12/16
Apolloscientific
Product number
OR912733
Product name
4-Piperidinepropanol
Purity
96%
Packaging
1g
Price
$90
Updated
2021/12/16
Matrix Scientific
Product number
020666
Product name
3-Piperidin-4-yl-propan-1-ol
Purity
95+%
Packaging
5g
Price
$145
Updated
2021/12/16
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piperidine-4-propanol Chemical Properties,Usage,Production

Uses

4-(3-Hydroxypropyl)piperidine is used in the synthesis of G-protein coupled receptor (GPR119) agonists based on a bicyclic amine scaffold. Also used in the synthesis and antimicrobial activities of novel quinoline derivatives.

Uses

piperidine-4-propanol is used in the synthesis of G-protein coupled receptor (GPR119) agonists based on a bicyclic amine scaffold. Also used in the synthesis and antimicrobial activities of no vel quinoline derivatives.

Synthesis

2629-72-3

7037-49-2

Platinum(IV) oxide (1.45 g, 6.4 mmol) was added to a mixed solution of 4-pyridinepropanol (10.0 g, 72.89 mmol) in methanol (110 mL) and 32% hydrochloric acid (18 mL) under argon protection. The reaction mixture was stirred vigorously under low pressure hydrogen (8 kPa) for 46 hours. Upon completion of the reaction, most of the catalyst was removed by filtration, followed by distillation under reduced pressure to remove the volatile solvent. The oily residue obtained was dissolved in 15% NaOH aqueous solution (80 mL) and extracted with dichloromethane (first 150 mL, then 3 x 100 mL). The organic phases were combined, washed with deionized water (20 mL) and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure and dried under vacuum to give 3-(4-piperidinyl)-1-propanol (10.3 g, 98% yield) as a white crystalline solid with a melting point of 58-60 °C. Thin layer chromatography (TLC) showed Rf = 0.2 (Expander: dichloromethane/methanol/28% ammonia = 50:10:1). Infrared spectroscopy (Nujol) showed characteristic absorption peaks located at 3290 cm?1 and 1320 cm?1. NMR hydrogen spectra (300 MHz, CD?OD) δ (ppm): 1.08-1.23 (m, 2H), 1.27-1.36 (m, 2H), 1.36-1.49 (m, 1H), 1.53-1.63 (m, 2H). 1.74 (br d, 2H, J≈13.4 Hz), 2.59 (dt, 2H, J=12.4, 2.6 Hz), 3.04 (td, 2H, J=12.4, 2.9 Hz), 3.56 (t, 2H, J=6.6 Hz). NMR carbon spectrum (75 MHz, CD?OD) δ (ppm): 31.5, 34.8, 35.2, 38.0, 47.9, 64.0. mass spectrum (ESI, MeOH) m/z (%): 287 (36) [2M+H]? , 144 (100) [M+H]? Molecular formula C?H??NO (molecular weight 143.2).

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 23, # 14, p. 3970 - 3990
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 16, p. 2537 - 2551
[3] Organic Letters, 2002, vol. 4, # 4, p. 549 - 552
[4] Tetrahedron, 1999, vol. 55, # 39, p. 11619 - 11639
[5] Journal of Polymer Science, 1959, vol. 40, p. 377,384

piperidine-4-propanol Preparation Products And Raw materials

Raw materials

Preparation Products

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piperidine-4-propanol Suppliers

Canada 1 China 119 India 1 United Kingdom 1 United States 8 Global 130
AF Biochem Co., Ltd.
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+86-028-60911900 13540204019
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sales@afbiochem.com
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China
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Shanghai AQBioPharma Co., Ltd.
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13661411401
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51370935-8011
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yinglv.que@aqbiopharma.com.cn
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China
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Shanghai AQ BioPharma Co., Ltd.
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13512160998
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China
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Suzhou Vosun Biotech Co.,Ltd
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18934576691
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0512-82177265
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China
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Shanghai Boyle Chemical Co., Ltd.
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+86-21-57758967
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J & K SCIENTIFIC LTD.
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86-10-82849933
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jkinfo@jkchemical.com
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PharmaBlock Sciences (Nanjing),Inc.
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Energy Chemical
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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86-027-87531808
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sales@chemwish.com
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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View Lastest Price from piperidine-4-propanol manufacturers

Career Henan Chemical Co
Product
piperidine-4-propanol 7037-49-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2018-08-13

7037-49-2, piperidine-4-propanolRelated Search:

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  • piperidine-4-propanol
  • 4-piperidinepropanol
  • 4-(3-Hydroxypropyl)piperidine
  • 4-Piperidine-1-propanol
  • Einecs 230-318-7
  • 3-(4-Piperidyl)-1-propanol
  • 3-(4-Piperidinyl)propanol
  • 3-(4-Piperidinyl)-1-propanol
  • 4-(3-Hydroxypropy)piperidine
  • 3-Piperidin-4-propan-1-ol
  • 4-Piperidinepropanol (6CI, 7CI, 8CI, 9CI, ACI)
  • 4-piperidinopropanol
  • 3-piperidin-4-yl-propan-1-ol, 97%min
  • 4-Piperidinepropanol - [P13257]
  • 7037-49-2
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