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IDRA 21

Product Name
IDRA 21
CAS No.
22503-72-6
Chemical Name
IDRA 21
Synonyms
AMPAKINE;IDRA 21;IDRA 21,98%;S-18986 IDRA-21 AMPAKINE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE;7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-...;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE;7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide;2H-1,2,4-Benzothiadiazine,7-chloro-3,4-dihydro-3-Methyl-, 1,1-dioxide
CBNumber
CB3468324
Molecular Formula
C8H9ClN2O2S
Formula Weight
232.69
MOL File
22503-72-6.mol
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IDRA 21 Property

Melting point:
209 °C(Solv: acetic acid (64-19-7))
Boiling point:
405.1±55.0 °C(Predicted)
Density 
1.394±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
9.78±0.40(Predicted)
color 
Off-White to Pale Yellow
InChIKey
VZRNTCHTJRLTMU-UHFFFAOYSA-N
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Safety

Safety Statements 
24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I5773
Product name
IDRA 21
Purity
≥98%
Packaging
5mg
Price
$210
Updated
2024/03/01
Tocris
Product number
1219
Product name
IDRA 21
Purity
≥98%(HPLC)
Packaging
10
Price
$183
Updated
2021/12/16
Tocris
Product number
1219
Product name
IDRA 21
Purity
≥98%(HPLC)
Packaging
50
Price
$770
Updated
2021/12/16
Usbiological
Product number
255490
Product name
IDRA 21
Packaging
10mg
Price
$423
Updated
2021/12/16
TRC
Product number
I232500
Product name
IDRA 21
Packaging
250mg
Price
$1540
Updated
2021/12/16
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IDRA 21 Chemical Properties,Usage,Production

Chemical Properties

white to off-white crystalline powder

Uses

IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.

Uses

IDRA-21 inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960).

Definition

ChEBI: 7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide is a benzothiadiazine.

Biological Activity

Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide ).

storage

Room temperature

IDRA 21 Preparation Products And Raw materials

Raw materials

Preparation Products

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IDRA 21 Suppliers

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View Lastest Price from IDRA 21 manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
IDRA 21 22503-72-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500
Release date
2023-08-02
Hebei Dangtong Import and export Co LTD
Product
IDRA 21 22503-72-6
Price
US $12.00-10.00/Grams
Min. Order
50Grams
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-17
Hebei Mojin Biotechnology Co.,Ltd
Product
IDRA 21 22503-72-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-05-16

22503-72-6, IDRA 21Related Search:

Methyltrichlorosilane Benzyl chloride Triphosgene IDRA 21 2-Amino-5-chlorobenzenesulfonamide

  • IDRA 21
  • IDRA 21,7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazineS,S-dioxide
  • 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE
  • 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE
  • 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE
  • IDRA 21,98%
  • 7-chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
  • 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 2H-1,2,4-Benzothiadiazine,7-chloro-3,4-dihydro-3-Methyl-, 1,1-dioxide
  • AMPAKINE
  • 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-...
  • IDRA 21 Benzothiadiazine,7-chloro- 3,4-dihydro-3-methyl-,1,1- dioxide
  • S-18986 IDRA-21 AMPAKINE
  • 22503-72-6
  • Ligand-Gated Ion Channels
  • Ion Channels
  • Ionotropic Glutamate Receptor Modulators
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • API