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ChemicalBook > CAS DataBase List > HUMAN VEGF165

HUMAN VEGF165

Description Source Background
Product Name
HUMAN VEGF165
CAS No.
127464-60-2
Chemical Name
HUMAN VEGF165
Synonyms
VPF;VEGF;MVCD1;mVEGF;RHVPF;RHVEGF;Vegf188;VEGF112;L VEGFA;MGC70609
CBNumber
CB3470679
Molecular Formula
NULL
Formula Weight
0
MOL File
Mol file
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HUMAN VEGF165 Property

storage temp. 
-20°C
form 
powder
color 
white
biological source
rat
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
V7259
Product name
Vascular Endothelial Growth Factor human
Purity
VEGF, recombinant, expressed in E. coli, powder, suitable for cell culture
Packaging
10μg
Price
$225
Updated
2025/07/31
Sigma-Aldrich
Product number
V3388
Product name
Vascular Endothelial Growth Factor (aa 207-318) human
Purity
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Packaging
5μG
Price
$672.49
Updated
2025/07/31
Sigma-Aldrich
Product number
SRP4365
Product name
VEGF165 from rat
Purity
recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
Packaging
10μG
Price
$356
Updated
2025/07/31
Sigma-Aldrich
Product number
SRP3182
Product name
VEGF human
Purity
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Packaging
10μG
Price
$439
Updated
2025/07/31
Sigma-Aldrich
Product number
SAB2502119
Product name
Anti-VEGFA antibody produced in goat
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100μG
Price
$586
Updated
2025/07/31
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HUMAN VEGF165 Chemical Properties,Usage,Production

Uses

VEGF human has been used as a chemoattractant for HUVECs (human umbilical vein endothelial cells) migration assay.

General Description

VEGF (vascular endothelial growth factor) signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant human VEGF is a 38.2kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

Biochem/physiol Actions

VEGF (vascular endothelial growth factor) is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intraocular neovascular syndromes. Polymorphism in VEGF at C(-634)G is linked with diabetic retinopathy in type 2 diabetes.

Description

Vascular Endothelial Growth Factor Human Recombinant produced in E.Coli is a double, non-glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 38.2kDa.
The VEGF is purified by proprietary chromatographic techniques.

Source

Escherichia Coli

Background

Vascular endothelial growth factor (VEGF) is an important signaling protein involved in vessel formation As its name implies, VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells ). VEGF mediates increased vascular permeability, induces vasculogenesis and endothelial cell production, promotes cell migration, and inhibits apoptosis. In vitro, VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor. VEGF is located in normal cartilage though only osteoarthritic cartilage expresses the VEGF receptors, NP1, VEGFR1 and VEGFR2. The VEGF level in the culture media from OA chondrocytes was more than 3 folds higher than in media from normal chondrocytes

HUMAN VEGF165 Preparation Products And Raw materials

Raw materials

Preparation Products

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127464-60-2, HUMAN VEGF165Related Search:


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  • Vascular Endothelial Growth Factor from mouse
  • Vascular Endothelial Growth Factor (aa 207-318) human
  • VEGF112
  • Anti-VEGFA antibody produced in goat
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  • HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR (165 AA)
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  • vascular endothelial growth factor*human recombin
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